Journal ArticleDOI
Adjuvant and Salvage Radiotherapy After Prostatectomy: AUA/ASTRO Guideline
Ian M. Thompson,Ian M. Thompson,Richard K. Valicenti,Richard K. Valicenti,Peter C. Albertsen,Peter C. Albertsen,Brian J. Davis,Brian J. Davis,S. Larry Goldenberg,S. Larry Goldenberg,Carol A. Hahn,Carol A. Hahn,Eric A. Klein,Eric A. Klein,Jeff M. Michalski,Jeff M. Michalski,Mack Roach,Mack Roach,Oliver Sartor,Oliver Sartor,J. Stuart Wolf,J. Stuart Wolf,Martha M. Faraday,Martha M. Faraday +23 more
TLDR
This guideline is provided for patient counseling, the use of radiotherapy in the adjuvant and salvage contexts, defining biochemical recurrence, and conducting a re-staging evaluation.About:
This article is published in The Journal of Urology.The article was published on 2013-08-01. It has received 372 citations till now. The article focuses on the topics: Guideline & Prostatectomy.read more
Citations
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Journal ArticleDOI
The Diagnosis and Treatment of Prostate Cancer: A Review.
Mark S. Litwin,Hung-Jui Tan +1 more
TL;DR: Advances in the diagnosis and treatment of prostate cancer have improved the ability to stratify patients by risk and allowed clinicians to recommend therapy based on cancer prognosis and patient preference.
Journal ArticleDOI
Androgen receptor gene aberrations in circulating cell-free DNA: biomarkers of therapeutic resistance in castration-resistant prostate cancer
Arun Azad,Stanislav Volik,Alexander W. Wyatt,Anne Haegert,Stephane Le Bihan,Robert H. Bell,Shawn Anderson,Brian McConeghy,Robert Shukin,Jenny Bazov,Jack F. Youngren,Pamela L. Paris,George Thomas,Eric J. Small,Yuzhuo Wang,Yuzhuo Wang,Martin E. Gleave,Martin E. Gleave,Colin Collins,Colin Collins,Kim N. Chi,Kim N. Chi +21 more
TL;DR: The data illustrate that genomic analysis of cfDNA is a minimally invasive method for interrogating mechanisms of therapeutic resistance in mCRPC and suggest that novel agents targeting the androgen–androgen receptor (AR) axis have altered the treatment paradigm.
Journal ArticleDOI
High-risk prostate cancer—classification and therapy
TL;DR: This Review critically evaluates the existing literature focused on defining the high-risk population, the management of patients with high- risk prostate cancer, and future directions to optimize care.
Journal ArticleDOI
68Ga-PSMA-11 PET/CT Mapping of Prostate Cancer Biochemical Recurrence After Radical Prostatectomy in 270 Patients with a PSA Level of Less Than 1.0 ng/mL: Impact on Salvage Radiotherapy Planning
Jeremie Calais,Johannes Czernin,Minsong Cao,Amar U. Kishan,John V. Hegde,Narek Shaverdian,Kiri A. Sandler,Fang-I Chu,Christopher R. King,Michael L. Steinberg,Isabel Rauscher,Nina-Sophie Schmidt-Hegemann,Thorsten D. Poeppel,Philipp Hetkamp,Francesco Ceci,Ken Herrmann,Wolfgang P. Fendler,Wolfgang P. Fendler,Matthias Eiber,Matthias Eiber,Nicholas G. Nickols +20 more
TL;DR: A post hoc analysis of an intention-to-treat population of 270 patients who underwent 68Ga-PSMA-11 PET/CT at 4 institutions for BCR after prostatectomy without prior radiotherapy at a PSA level of less than 1 ng/mL implied a major impact on SRT planning.
Journal ArticleDOI
Genomic Classifier Identifies Men With Adverse Pathology After Radical Prostatectomy Who Benefit From Adjuvant Radiation Therapy
Robert B. Den,Kasra Yousefi,Edouard J. Trabulsi,Firas Abdollah,Voleak Choeurng,Felix Y. Feng,Adam P. Dicker,Costas D. Lallas,Leonard G. Gomella,Elai Davicioni,R. Jeffrey Karnes +10 more
TL;DR: In patients treated with post-RP RT, GC is prognostic for the development of clinical metastasis beyond routine clinical and pathologic features, and provides the first rational selection of timing for post- RP RT.
References
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Journal ArticleDOI
Natural history of progression after PSA elevation following radical prostatectomy.
Charles R. Pound,Alan W. Partin,Mario A. Eisenberger,Daniel W. Chan,Jay D. Pearson,Patrick C. Walsh +5 more
TL;DR: Several clinical parameters help predict the outcomes of men with PSA elevation after radical prostatectomy, and these data may be useful in the design of clinical trials, the identification of men for enrollment into experimental protocols, and counseling men regarding the timing of administration of adjuvant therapies.
Journal ArticleDOI
Adjuvant Radiotherapy for Pathological T3N0M0 Prostate Cancer Significantly Reduces Risk of Metastases and Improves Survival: Long-Term Followup of a Randomized Clinical Trial
Ian M. Thompson,Catherine M. Tangen,Jorge Paradelo,M. Scott Lucia,Gary J. Miller,Dean A. Troyer,Edward M. Messing,Jeffrey D. Forman,Joseph L. Chin,Gregory P. Swanson,Edith D. Canby-Hagino,E. David Crawford +11 more
TL;DR: Adjuvant radiotherapy after radical prostatectomy for a man with pT3N0M0 prostate cancer significantly reduces the risk of metastasis and increases survival.
Journal ArticleDOI
Postoperative radiotherapy after radical prostatectomy: a randomised controlled trial (EORTC trial 22911)
Michel Bolla,Hendrik Van Poppel,Laurence Collette,Paul Van Cangh,K. Vekemans,Luigi F. Da Pozzo,Theo M. de Reijke,Antony Verbaeys,Jean-François Bosset,Roland Van Velthoven,Jean-Marie Maréchal,Pierre Scalliet,Karin Haustermans,Marianne Pierart +13 more
TL;DR: Immediate external irradiation after radical prostatectomy improves biochemical progression-free survival and local control in patients with positive surgical margins or pT3 prostate cancer who are at high risk of progression.
Journal ArticleDOI
Long-term biochemical disease-free and cancer-specific survival following anatomic radical retropubic prostatectomy. The 15-year Johns Hopkins experience.
TL;DR: In this paper, a large series of 2404 men with a mean follow-up of 6.3 plus or minus 4.2 years (range, 1-17) after anatomic RRP for clinically localized prostate cancer, 412 men have recurred.
Journal ArticleDOI
Adjuvant radiotherapy for pathologically advanced prostate cancer: a randomized clinical trial.
Ian M. Thompson,Catherine M. Tangen,Jorge Paradelo,M. Scott Lucia,Gary J. Miller,Dean A. Troyer,Edward M. Messing,Jeffrey D. Forman,Joseph L. Chin,Gregory P. Swanson,Edith Canby-Hagino,E. David Crawford +11 more
TL;DR: In men who had undergone radical prostatectomy for pathologically advanced prostate cancer, adjuvant radiotherapy resulted in significantly reduced risk of PSA relapse and disease recurrence, although the improvements in metastasis-free survival and overall survival were not statistically significant.
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Postoperative radiotherapy after radical prostatectomy for high-risk prostate cancer: long-term results of a randomised controlled trial (EORTC trial 22911)
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