Advances in Stereoconvergent Catalysis from 2005 to 2015: Transition-Metal-Mediated Stereoablative Reactions, Dynamic Kinetic Resolutions, and Dynamic Kinetic Asymmetric Transformations
TLDR
This Review summarizes major advances in nonenzymatic, transition-metal-promoted dynamic asymmetric transformations reported between 2005 and 2015.Abstract:
Stereoconvergent catalysis is an important subset of asymmetric synthesis that encompasses stereoablative transformations, dynamic kinetic resolutions, and dynamic kinetic asymmetric transformations. Initially, only enzymes were known to catalyze dynamic kinetic processes, but recently various synthetic catalysts have been developed. This Review summarizes major advances in nonenzymatic, transition-metal-promoted dynamic asymmetric transformations reported between 2005 and 2015.read more
Citations
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A Pharmaceutical Industry Perspective on Sustainable Metal Catalysis
TL;DR: In this paper, the authors highlight a number of important considerations for the design of new and improved sustainable metal-catalyzed transformations in order to facilitate rapid adoption by the pharmaceutical industry.
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Nickel-Catalyzed Enantioselective Reductive Cross-Coupling of Styrenyl Aziridines
TL;DR: Multivariate analysis revealed that ligand polarizability, among other features, influences the observed enantioselectivity, shedding light on the success of this emerging ligand class for enantiOSElective Ni catalysis.
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Quaternary stereocentres via an enantioconvergent catalytic S N 1 reaction
TL;DR: This work reports asymmetric catalysis of an SN1-type reaction mechanism that results in the enantioselective construction of quaternary stereocentres from racemic precursors and provides a foundation for theEnantioconvergent synthesis of other fully substituted carbon stereocentre synthesis.
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Enantioselective Formation of Quaternary Centers by Allylic Alkylation with First-Row Transition-Metal Catalysts
Lars Süsse,Brian M. Stoltz +1 more
TL;DR: In this article, a review summarizes examples for the assembly of quaternary stereocenters using prochiral allylic substrates and hard, achiral nucleophiles in the presence of copper complexes.
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Redox-Tag Processes: Intramolecular Electron Transfer and Its Broad Relationship to Redox Reactions in General
Yohei Okada,Kazuhiro Chiba +1 more
TL;DR: This Review highlights the importance of intramolecular SET processes in the field of synthetic organic chemistry, which seem to be more elusive than the intermolecular versions, since they are net redox-neutral and thus cannot simply be regarded as oxidations or reductions.
References
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Mild metal-catalyzed C–H activation: examples and concepts
TL;DR: This review presents the current state of the art in this field and detail C-H activation transformations reported since 2011 that proceed either at or below ambient temperature, in the absence of strongly acidic or basic additives or without strong oxidants.