Advances in Understanding of Pathogenesis and Treatment of Immune-Mediated Kidney Disease: A Review
TLDR
In this paper , the authors discuss the recent advancements in immune-mediated kidney disease via the lens of direct and indirect immune mediated mechanisms, which has culminated in the development of multiple therapeutic agents that consistently improved renal and patient outcomes.About:
This article is published in American Journal of Kidney Diseases.The article was published on 2022-04-01 and is currently open access. It has received 18 citations till now. The article focuses on the topics: Medicine & Membranous nephropathy.read more
Citations
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Inflammation: A New Look at an Old Problem
TL;DR: The aim of the review is to provide theoretical arguments for the need for an up-to-date theory of the relationship between key human pathological processes based on the integrative role of the molecular mechanisms of cellular and tissue pro-inflammatory stress.
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Applications and Mechanisms of Tripterygium Wilfordii Hook. F. and its Preparations in Kidney Diseases
TL;DR: The main preparations of TwHF on the Chinese market and their characteristics are introduced and a summary of the clinical applications and influential mechanisms of Tw HF and its preparations in kidney diseases is summarized.
Journal ArticleDOI
Pathogenic T-Cell Responses in Immune-Mediated Glomerulonephritis
TL;DR: Detailed knowledge of the underlying immune mechanisms involved with cGN will enable the identification of novel therapeutic targets for the replacement or reduction in standard immunosuppressive therapy or the treatment of refractory disease.
Journal ArticleDOI
LC-MS/MS based metabolomics and proteomics reveal candidate biomarkers and molecular mechanism of early IgA nephropathy
Di Zhang,Yaohan Li,Mingzhu Liang,Yan Liang,Ji-Li Tian,Qi He,Bingxian Yang,Jun Jin,Meifang Zhu +8 more
TL;DR: In this article , integrative proteomics and metabolomics were aimed at exploring the mechanism of immunoglobulin A nephropathy (IgAN) and identifying potential biomarkers.
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The Role of Heme Oxygenase-1 as an Immunomodulator in Kidney Disease
TL;DR: In this paper , the role of HO-1 in kidney disease and the most recent observations of the effect on immune pathways and responses both in animal models of immune-mediated disease forms and in patient studies.
References
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Rituximab versus Cyclophosphamide for ANCA-Associated Vasculitis
John H. Stone,Peter A. Merkel,Robert Spiera,Philip Seo,Carol A. Langford,Gary S. Hoffman,Cees G. M. Kallenberg,E. William St. Clair,Anthony M. Turkiewicz,Nadia K. Tchao,Lisa Webber,Linna Ding,Lourdes P. Sejismundo,Kathleen Mieras,David Weitzenkamp,David Ikle,Vicki Seyfert-Margolis,Mark Mueller,Paul Brunetta,Nancy B. Allen,Fernando C. Fervenza,Duvuru Geetha,Karina A. Keogh,Eugene Y. Kissin,Paul A. Monach,Tobias Peikert,Coen A. Stegeman,Steven R. Ytterberg,Ulrich Specks +28 more
TL;DR: Rituximab therapy was not inferior to daily cyclophosphamide treatment for induction of remission in severe ANCA-associated vasculitis and may be superior in relapsing disease.
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M-type phospholipase A2 receptor as target antigen in idiopathic membranous nephropathy.
Laurence H. Beck,Ramon G. Bonegio,Gérard Lambeau,David M. Beck,David W. Powell,Timothy D. Cummins,Jon B. Klein,David J. Salant +7 more
TL;DR: A majority of patients with idiopathic membranous nephropathy have antibodies against a conformation-dependent epitope in PLA(2)R, indicating that PLA( 2)R is a major antigen in this disease.
Journal ArticleDOI
Rituximab versus Cyclophosphamide in ANCA-Associated Renal Vasculitis
Rachel B Jones,Jan Willem Cohen Tervaert,Thomas H. Hauser,Raashid Luqmani,Matthew D. Morgan,Chen Au Peh,Caroline O. S. Savage,Mårten Segelmark,Vladimir Tesar,Pieter van Paassen,D Walsh,Michael Walsh,Kerstin Westman,David Jayne +13 more
TL;DR: A rituximab-based regimen was not superior to standard intravenous cyclophosphamide for severe ANCA-associated vasculitis and was not associated with reductions in early severe adverse events.
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A Randomized Trial of Maintenance Therapy for Vasculitis Associated with Antineutrophil Cytoplasmic Autoantibodies
David Jayne,Niels Rasmussen,Konrad Andrassy,Paul A. Bacon,Jan Willem Cohen Tervaert,J. Dadoniene,Agneta Ekstrand,Gill Gaskin,Gina Gregorini,Kirsten de Groot,Wolfgang L. Gross,E. Christiaan Hagen,Eduardo Mirapeix,Erna Pettersson,Carl Siegert,Alberto Sinico,Vladimir Tesar,Kerstin Westman,Charles D. Pusey +18 more
TL;DR: In patients with generalized vasculitis, the withdrawal of cyclophosphamide and the substitution of azathioprine after remission did not increase the rate of relapse, suggesting the duration of exposure to cycloph phosphamide may be safely reduced.
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American College of Rheumatology guidelines for screening, treatment, and management of lupus nephritis
Bevra H. Hahn,Maureen McMahon,Alan H. Wilkinson,W. Dean Wallace,David I. Daikh,John FitzGerald,George Karpouzas,Joan T. Merrill,Daniel J. Wallace,Jinoos Yazdany,Rosalind Ramsey-Goldman,Karandeep Singh,Mazdak A. Khalighi,Soo I. Choi,Maneesh Gogia,Suzanne Kafaja,Mohammad Kamgar,Christine Lau,William J. Martin,Sefali Parikh,Justin Peng,Anjay Rastogi,Weiling Chen,Jennifer M. Grossman +23 more
TL;DR: The management strategies discussed here apply to lupus nephritis in adults, particularly to those receiving care in the United States of America, and include interventions that were available in theUnited States as of April 2011.