Age-dependent response of CCAAT/enhancer binding proteins following traumatic brain injury in mice.
Rajat Sandhir,Nancy E.J. Berman +1 more
TLDR
In this paper, the authors investigated the involvement of the transcription factors belonging to the CCAAT/enhancer binding protein (C/EBP) family that regulate expression of many of the pro-inflammatory genes which show increased expression following injury to the aged brain.About:
This article is published in Neurochemistry International.The article was published on 2010-01-01 and is currently open access. It has received 50 citations till now. The article focuses on the topics: Enhancer binding & Ccaat-enhancer-binding proteins.read more
Citations
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Traumatic brain injury: a risk factor for Alzheimer's disease.
TL;DR: This review focuses on AD related genes which are expressed during TBI and its relevance to progression of the disease and understanding will help to diagnose the risk of TBI patients to develop AD and design therapeutic interventions.
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Traumatic brain injury in aged animals increases lesion size and chronically alters microglial/macrophage classical and alternative activation states
TL;DR: Altered relative M1/M2 activation and an nicotinamide adenine dinucleotide phosphate oxidase (NADPH oxidase)-mediated shift in redox state might contribute to worse outcomes observed in older TBI animals by creating a more proinflammatory M1 MG/Mɸ activation state.
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Aging of cerebral white matter.
Huan Liu,Yuanyuan Yang,Yuguo Xia,Wen Zhu,Rehana K. Leak,Zhishuo Wei,Jianyi Wang,Xiaoming Hu,Xiaoming Hu +8 more
TL;DR: The structural and functional alterations of WM in natural aging are summarized and how age-related WM changes influence the progression of various brain disorders, including ischemic and hemorrhagic stroke, TBI, Alzheimer's disease, and Parkinson's disease are discussed.
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The Controlled Cortical Impact Model: Applications, Considerations for Researchers, and Future Directions.
Nicole Osier,C. Edward Dixon +1 more
TL;DR: Controlled cortical impact is a mechanical model of traumatic brain injury (TBI) that was developed nearly 30 years ago with the goal of creating a testing platform to determine the biomechanical properties of brain tissue exposed to direct mechanical deformation.
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Influence of age on brain edema formation, secondary brain damage and inflammatory response after brain trauma in mice.
Ralph Timaru-Kast,Clara Luh,Philipp Gotthardt,Changsheng Huang,Michael K. E. Schäfer,Kristin Engelhard,Serge C. Thal +6 more
TL;DR: Old animals are prone to functional deficits and strong ipsilateral cerebral inflammation without major differences in morphological brain damage compared to young, and Pulmonary interleukin 1β expression was up-regulated after cerebral injury only in young, not aged mice.
References
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Relative expression software tool (REST©) for group-wise comparison and statistical analysis of relative expression results in real-time PCR
TL;DR: Development and application of REST is explained, the usefulness of relative expression in real-time PCR using REST is discussed and the mathematical model used is based on the PCR efficiencies and the mean crossing point deviation between the sample and control group.
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Roles of CHOP/GADD153 in endoplasmic reticulum stress.
TL;DR: The current understanding of the roles of C/EBP homologous protein (CHOP) and GADD153 in ER stress-mediated apoptosis and in diseases including diabetes, brain ischemia and neurodegenerative disease are summarized.
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Gadd153 Sensitizes Cells to Endoplasmic Reticulum Stress by Down-Regulating Bcl2 and Perturbing the Cellular Redox State
TL;DR: Gadd153 sensitizes cells to ER stress through mechanisms that involve down-regulation of Bcl2 and enhanced oxidant injury and protected cells from ER stress-induced cell death.
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The impact of traumatic brain injuries: A global perspective
Adnan A. Hyder,Colleen A. Wunderlich,Prasanthi Puvanachandra,Gopalkrishna Gururaj,Olive Kobusingye +4 more
TL;DR: There is a large gap in data on incidence, risk factors, sequelae, financial costs, and social impact of TBI, and this should be addressed through planning of comprehensive TBI prevention programs in LMICs through well-established surveillance systems.
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The role of inflammation in CNS injury and disease.
TL;DR: The complex interplay between inflammatory mediators, ageing, genetic background, and environmental factors may ultimately regulate the outcome of acute CNS injury and progression of chronic neurodegeneration, and be critical for development of effective therapies for CNS diseases.