Journal ArticleDOI
Age-related decline in female fertility is not due to diminished capacity of the uterus to sustain embryo implantation*
Daniel Navot,Michael R. Drews,P.A. Bergh,Ida Guzman,Alexis Karstaedt,Richard T. Scott,G. John Garrisi,G E Hofmann +7 more
TLDR
The capacity to conceive and to gestate a conception to term when oocyte quality is controlled appears to be independent of uterine aging through the fifth decade of life.Citations
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Egg quality in fish: what makes a good egg?
TL;DR: The genetic mechanisms underpinning oocyte and embryo growth and development are a priority for research and the products synthesized in ovoand the mechanisms controlling their expression are likely to play a central role in determining egg quality.
Journal ArticleDOI
Commuting the death sentence: how oocytes strive to survive.
TL;DR: New insights into the mechanisms that underlie germ-cell apoptosis have been provided by the study of oocyte death in lower organisms and in genetically manipulated mice that lack apoptosis-regulatory proteins.
Journal ArticleDOI
Positive outcome after preimplantation diagnosis of aneuploidy in human embryos
Santiago Munné,Cristina Magli,Jacques Cohen,P.C. Morton,Sasha Sadowy,Luca Gianaroli,Michael J. Tucker,Carmen Márquez,David B. Sable,Anna Pia Ferraretti,Joe B. Massey,Richard T. Scott +11 more
TL;DR: PGD of aneuploidy reduced embryo loss after implantation, but implantation rates were not significantly improved, but the proportion of ongoing and delivered babies was increased.
Journal ArticleDOI
Developmental ability of chromosomally abnormal human embryos to develop to the blastocyst stage
TL;DR: Even though there is a strong selection against chromosomally abnormal embryos, extended culture to day 5 or 6 cannot be used as a reliable tool to select against clinically relevant chromosome abnormalities such as trisomies.
Journal ArticleDOI
Improved implantation after preimplantation genetic diagnosis of aneuploidy
Santiago Munné,M. Sandalinas,Tomas Escudero,E. Velilla,Renee Walmsley,Sasha Sadowy,Jacques Cohen,David Sable +7 more
TL;DR: It was found that women of advanced reproductive age (average age 40 years) had a higher implantation rate than their matched controls treated with standard IVF (11%) and this increase was not observed in patients with two or more previous IVF cycles or patients with fewer than eight zygotes.
References
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Journal ArticleDOI
Female fecundity as a function of age: results of artificial insemination in 2193 nulliparous women with azoospermic husbands. Federation CECOS.
Schwartz D,Mayaux Mj +1 more
TL;DR: In this paper, Leridon has suggested that fertility is decreased in women over 30 years of age, but this group includes women with a wide range of ages and it was not possible to determine from the data whether the decrease in fertility was biologic or simply the consequence of diminished sexual activity.
Journal ArticleDOI
Poor oocyte quality rather than implantation failure as a cause of age-related decline in female fertility.
Daniel Navot,R.A. Bergh,M.A. Williams,G.J. Garrisi,Ida Guzman,Benjamin Sandler,Lawrence Grunfeld +6 more
TL;DR: The data suggest that the age-related decline in female fertility is attributable to oocyte quality and is correctable by ovum donation, and the uterus can adequately sustain pregnancies even when reproductive potential is artificially prolonged into the late 40s.
Journal Article
Spontaneous abortion risks in man: data from reproductive histories collected in a medical genetics unit.
D Warburton,F C Fraser +1 more
Journal ArticleDOI
Delaying childbearing: effect of age on fecundity and outcome of pregnancy.
B.M. van Noord-Zaadstra,Caspar W. N. Looman,H. Alsbach,J.D.F. Habbema,E.R. te Velde,J. Karbaat +5 more
TL;DR: After the age of 31 the probability of conception falls rapidly, but this can be partly compensated for by continuing insemination for more cycles, and the probability for an adverse pregnancy outcome starts to increase at about the same age.
Journal ArticleDOI
Artificially Induced Endometrial Cycles and Establishment of Pregnancies in the Absence of Ovaries
Daniel Navot,Neri Laufer,Juri Kopolovic,Roni Rabinowitz,Arie Birkenfeld,Aby Lewin,Menachem Granat,Ehud J. Margalioth,Joseph G. Schenker +8 more
TL;DR: It is biologically feasible to simulate the essential hormonal and endometrial milieu of a fertile menstrual cycle and early gestation solely by the administration of estrogen and progesterone.