Book ChapterDOI
Alginate-based hydrogels for drug delivery applications
Priyanka Ray,Mala Maity,Harekrushna Barik,Girija Sankar Sahoo,Saquib Hasnain,Mohammad Niyaz Hoda,Amit Kumar Nayak +6 more
- pp 41-70
TLDR
This chapter is intended to present a comprehensive overview of the existing state-of-the-art technology in producing various alginate-based hydrogels and their evaluations for the use in drug delivery.Abstract:
The biopolymeric hydrogels are being employed as the promising carriers for delivery of numerous kinds of drug candidates. Hydrogel systems are capable of absorbing higher volume of aqueous fluid while keeping intactness of the structural features. These also provide an easy implementation of the targeted and controlled releasing of drugs to the specific organs. Their use can minimize the unfavorable side effects of conventional drug delivery. Alginate is an abundant natural polysaccharide that possesses various freely existing hydroxyl and carboxyl functional groups along with its structural backbone and thus can be modified chemically. Alginate-based hydrogels have been designed by using different strategies which are either based on various kinds of physical and/or chemical cross-linking methodologies. Recent years, the drug delivery research and development have witnessed a tremendous growth for the prospective use of various alginate-based hydrogels. Due to increasing interest and great potential of these alginate-based hydrogels, this chapter is intended to present a comprehensive overview of the existing state-of-the-art technology in producing various alginate-based hydrogels and their evaluations for the use in drug delivery.read more
Citations
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Journal ArticleDOI
Progress and Prospects of Polymer-Based Drug Delivery Systems for Bone Tissue Regeneration.
Vyacheslav Ogay,Ellina A. Mun,Gulshakhar Kudaibergen,Murat Baidarbekov,Kuat Kassymbek,Zharylkasyn Zharkinbekov,Arman Saparov +6 more
TL;DR: The most recent advances in the field of polymer-based drug delivery systems for the promotion of bone tissue regeneration and the physical-chemical modifications of polymers for controlled and sustained release of one or more drugs are discussed.
Journal ArticleDOI
Multicomponent Interpenetrating metal based Alginate-Carrageenan biopolymer Hydrogel beads substantiated by Graphene oxide for efficient removal of Methylene Blue from waste water
TL;DR: In this paper , Graphene oxide-based hydrogel beads using copper metal ions as ionic crosslinker were used for removal of harmful dyes from the waste water as well as from aqueous waters.
Book ChapterDOI
Uses of tailored polysaccharides in dentistry
TL;DR: A considerable volume of research has recently been evidenced for dental drug delivery and dental tissue restoration/regeneration with the use of many polysaccharides and their tailored forms.
Journal ArticleDOI
Development of nanosilver embedded injectable liquid crystalline hydrogel from alginate and chitosan for potent antibacterial and anticancer applications
TL;DR: In this paper , a nano-ilver embedded Schiff base hydrogel from biopolymers alginate and chitosan was developed and demonstrated its application in the injectable delivery of anticancer drug Dox.
Book ChapterDOI
Biomedical applications of polysaccharides
TL;DR: In this article, the different biomedical uses of polysaccharides have been reviewed, such as delivery of drugs, growth factors, gene materials, protein encapsulation, wound healing, tissue regeneration, bioimaging, etc.
References
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Journal ArticleDOI
Alginate: properties and biomedical applications
Kuen Yong Lee,David J. Mooney +1 more
TL;DR: This review will provide a comprehensive overview of general properties of alginate and its hydrogels, their biomedical applications, and suggest new perspectives for future studies with these polymers.
Journal ArticleDOI
Hydrogels for biomedical applications.
TL;DR: The composition and synthesis of hydrogels, the character of their absorbed water, and permeation of solutes within their swollen matrices are reviewed to identify the most important properties relevant to their biomedical applications.
Journal ArticleDOI
Hydrogels in regenerative medicine
Brandon V. Slaughter,Shahana S. Khurshid,Omar Z. Fisher,Ali Khademhosseini,Nicholas A. Peppas +4 more
TL;DR: The properties of hydrogels that are important for tissue engineering applications and the inherent material design constraints and challenges are discussed.
Journal ArticleDOI
Alginate as immobilization matrix for cells
Olav Smidsrød,Gudmund Skjåk-Bræk +1 more
TL;DR: This review evaluates the potential of entrapment of cells within spheres of Ca2+ alginate gels on the basis of the current knowledge of structural and functional relationships in alginATE gels.
Journal ArticleDOI
Polyionic hydrocolloids for the intestinal delivery of protein drugs: alginate and chitosan--a review.
Meera George,T. Emilia Abraham +1 more
TL;DR: Alginate, being an anionic polymer with carboxyl end groups, is a good mucoadhesive agent and cross-linked alginate has more capacity to retain the entrapped drugs and mixing of alginates with other polymers such as neutral gums, chitosan, and eudragit have been found to solve the problem of drug leaching.