Journal ArticleDOI
Altered behaviors in male mice, male quail, and salamander larvae following early exposures to the estrogenic pesticide methoxychlor.
TLDR
The results of these studies indicate that developmental exposures to environmental chemicals with hormonal activities produce undesirable behaviors that may affect population dynamics and survivability of exposed species.About:
This article is published in Neurotoxicology and Teratology.The article was published on 2002-01-01. It has received 57 citations till now. The article focuses on the topics: Startle reaction & Population.read more
Citations
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Behavioural responses to human-induced environmental change.
Ulla Tuomainen,Ulrika Candolin +1 more
TL;DR: A growing number of studies find human disturbances to induce behavioural responses, both directly and by altering factors that influence fitness as mentioned in this paper, such as changes in the transmission of information, the concentration of endocrine disrupters, the availability of resources, the possibility of dispersal and the abundance of interacting species.
Journal ArticleDOI
Abnormal behaviours induced by chemical pollution: a review of the evidence and new challenges
Sarah M. Zala,Dustin J. Penn +1 more
TL;DR: Behaviour might provide a useful indicator or biomarker for detecting harmful chemical contaminants; however, more integration between toxicology and behavioural ecology is needed to determine whether and how EDCs affect humans and other vertebrates outside of the laboratory.
Journal ArticleDOI
Pesticide methoxychlor promotes the epigenetic transgenerational inheritance of adult-onset disease through the female germline.
TL;DR: Observations indicate that the pesticide methoxychlor has the potential to promote the epigenetic transgenerational inheritance of disease and the sperm epimutations appear to provide exposure specific epigenetic biomarkers forTransgenerational disease and ancestral environmental exposures.
Journal ArticleDOI
Specific transgenerational imprinting effects of the endocrine disruptor methoxychlor on male gametes
TL;DR: The reported effects of EDCs on human male spermatogenesis might be mediated by complex imprinting alterations analogous to those described in this study, which suggests that not only DNA methylation but also other epigenetic modifications can explain the transgenerational effects of MXC.
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Neuroendocrine and behavioral effects of embryonic exposure to endocrine disrupting chemicals in birds.
Mary Ann Ottinger,Emma T. Lavoie,N. Thompson,Ashley Barton,Kasen Whitehouse,Meredith Barton,Mahmoud Abdelnabi,Michael T. Quinn,Michael T. Quinn,Giancarlo Panzica,Carla Viglietti-Panzica +10 more
TL;DR: Behavioral alterations have the advantage of revealing both direct and indirect effects of exposure to an EDC and in some cases can provide a valuable clue into functional deficits at different physiological levels.
References
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Journal ArticleDOI
Developmental effects of endocrine-disrupting chemicals in wildlife and humans.
TL;DR: Mechanisms underlying the disruption of the development of vital systems, such as the endocrine, reproductive, and immune systems, are discussed with reference to wildlife, laboratory animals, and humans.
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Persistent DDT metabolite p,p'-DDE is a potent androgen receptor antagonist.
William R. Kelce,Stone Cr,Susan C. Laws,Leon Earl Gray,Jon A. Kemppainen,Elizabeth M. Wilson +5 more
TL;DR: It is reported that the major and persistent DDT metabolite,P,P′-DDE (l,l-dichloro-2,2-bis(P- chlorophenyl)ethylene), has little ability to bind the oestrogen receptor, but inhibits androgen binding to the androgen receptor.
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Our stolen future: are we threatening our fertility, intelligence, and survival? : a scientific detective story
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Developmental effects of an environmental antiandrogen: the fungicide vinclozolin alters sex differentiation of the male rat.
TL;DR: The observation of perinatal-induced agenesis of the prostate and blocked testicular descent, a pattern of malformations nearly identical to that reported for the antiandrogen flutamide, is consistent with other recent evidence that this fungicide is an androgen-receptor antagonist.
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Assessing environmental chemicals for estrogenicity using a combination of in vitro and in vivo assays.
TL;DR: Three assays for detecting estrogenicity were conducted on 10 chemicals with known or suspected estrogenic activity, providing information on three levels of hormonal activity (receptor binding, transcriptional activation, and an in vivo effect in an estrogen-responsive tissue), and results were consistent among the three assays.