Altered Negative BOLD Responses in the Default-Mode Network during Emotion Processing in Depressed Subjects
Simone Grimm,Peter Boesiger,Johannes Beck,Daniel Schuepbach,Felix Bermpohl,Martin Walter,Jutta Ernst,Daniel Hell,Heinz Boeker,Georg Northoff,Georg Northoff +10 more
TLDR
It is demonstrated that default-mode network NBRs are reduced in MDD and modulate these patients' abnormally negative emotions.About:
This article is published in Neuropsychopharmacology.The article was published on 2009-03-01 and is currently open access. It has received 327 citations till now. The article focuses on the topics: Posterior cingulate & Default mode network.read more
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Neurocircuitry of Mood Disorders
Joseph L. Price,Wayne C. Drevets +1 more
TL;DR: A system has been described that links the medial prefrontal cortex and a few related cortical areas to the amygdala, the ventral striatum and pallidum, the medial thalamus, the hypothalamus, and the periaqueductal gray and other parts of the brainstem, which indicates that this system is centrally involved in mood disorders.
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The default mode network and self-referential processes in depression
Yvette I. Sheline,M Deanna,Joseph L. Price,Melissa M. Rundle,S. Neil Vaishnavi,Abraham Z. Snyder,Mark A. Mintun,Suzhi Wang,Rebecca S. Coalson,Marcus E. Raichle +9 more
TL;DR: Depression is characterized by both stimulus-induced heightened activity and a failure to normally down-regulate activity broadly within the DMN, and these findings provide a brain network framework within which to consider the pathophysiology of depression.
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Default Mode Network Activity and Connectivity in Psychopathology
TL;DR: Functional magnetic resonance imaging studies have revealed that the DMN in the healthy brain is associated with stimulus-independent thought and self-reflection and that greater suppression of theDMN isassociated with better performance on attention-demanding tasks.
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Resting-state functional MRI in depression unmasks increased connectivity between networks via the dorsal nexus
TL;DR: It is suggested that the newly identified dorsal nexus plays a critical role in depressive symptomatology, in effect “hot wiring” networks together; it further suggests that reducing increased connectivity of the dorsal nexus presents a potential therapeutic target.
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Frontocingulate Dysfunction in Depression: Toward Biomarkers of Treatment Response
TL;DR: It is hypothesized that elevated resting rACC activity confers better treatment outcomes by fostering adaptive self-referential processing and by helping to recalibrate relationships between the default network and a ‘task-positive network’ that comprises dorsolateral prefrontal and dorsal cingulate regions implicated in cognitive control.
References
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Journal ArticleDOI
An inventory for measuring depression
TL;DR: The difficulties inherent in obtaining consistent and adequate diagnoses for the purposes of research and therapy have been pointed out and a wide variety of psychiatric rating scales have been developed.
Journal ArticleDOI
The assessment and analysis of handedness: The Edinburgh inventory
TL;DR: An inventory of 20 items with a set of instructions and response- and computational-conventions is proposed and the results obtained from a young adult population numbering some 1100 individuals are reported.
Journal ArticleDOI
A rating scale for depression
TL;DR: The present scale has been devised for use only on patients already diagnosed as suffering from affective disorder of depressive type, used for quantifying the results of an interview, and its value depends entirely on the skill of the interviewer in eliciting the necessary information.
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A default mode of brain function.
Marcus E. Raichle,Ann Mary MacLeod,Abraham Z. Snyder,William J. Powers,Debra A. Gusnard,Gordon L. Shulman +5 more
TL;DR: A baseline state of the normal adult human brain in terms of the brain oxygen extraction fraction or OEF is identified, suggesting the existence of an organized, baseline default mode of brain function that is suspended during specific goal-directed behaviors.
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The human brain is intrinsically organized into dynamic, anticorrelated functional networks
Michael D. Fox,Abraham Z. Snyder,Justin L. Vincent,Maurizio Corbetta,David C. Van Essen,Marcus E. Raichle +5 more
TL;DR: It is suggested that both task-driven neuronal responses and behavior are reflections of this dynamic, ongoing, functional organization of the brain, featuring the presence of anticorrelated networks in the absence of overt task performance.