Journal ArticleDOI
"Alveolar" and whole lung phospholipids of newborn lambs.
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TLDR
It is concluded that respiration of the newborn has a profound effect both mechanically and metabolically upon the liberation and elaboration of surface-active material.Abstract:
SummaryFifteen newborn lambs ranging in age from 10 min to 192 hours were studied. The qualitative and quantitative nature of “alveolar” phospholipids and whole lung tissue phospholipids were determined and compared with data previously obtained on term fetuses. Sequential lung washings removed practically all of the surface-active material from the internal surface of the lung. The “alveolar” phospholipids increased twofold in 10 min after the onset of respiration, fourfold in the first 24 hours and eightfold in the second day of life. The “alveolar” phospholipid composition of the newborn is similar to the term fetus, but differs from whole lung tissue phospholipids. The percentage minimal disaturates of the phosphatidylcholine of the newborn is slightly higher than that of the term fetus. “Alveolar” disaturated phosphatidylcholine represents the major portion of dipalmitoyl phosphatidylcholine. Phosphatidyldimethylethanolamine was isolated from “alveolar” phospholipids. This phospholipid contains a hig...read more
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Journal ArticleDOI
In vivo lung lavage as an experimental model of the respiratory distress syndrome.
TL;DR: Using adult guinea‐pigs, an experimental model in which alveolar surfactant phospholipids are removed by repeated lung lavage in viao, and in which the short‐term survival of the animals is ensured by artificial ventilation is proposed.
Journal ArticleDOI
The composition, structure and function of lipids in the tissues of ruminant animals.
TL;DR: The fatty acids of ruminant tissues are characterized by comparatively high concentrations of odd-chain and branched-chain fatty acids and of positional and configurational isomers of mono- and diuns saturated fatty acids, and, at the same time, by comparatively low concentrations of polyunsaturated fatty acids.
Journal ArticleDOI
Effects of tracheal instillation of natural surfactant in premature lambs. I. Clinical and autopsy findings.
Forrest H. Adams,Bernard Towers,Alan B Osher,Machiko Ikegami,Tetsuro Fujiwara,Masahiko Nozaki +5 more
TL;DR: It is concluded that tracheal instillation of natural surfactant into the premature lamb protects the lungs from developing many features characteristic of the respiratory distress syndrome.
Journal ArticleDOI
Lung phospholipids of human fetuses and infants with and without hyaline membrane disease
Forrest H. Adams,Forrest H. Adams,Tetsuro Fujiwara,Tetsuro Fujiwara,George C. Emmanouilides,George C. Emmanouilides,Niels Räihä,Niels Räihä +7 more
TL;DR: The lung phospholipid content and composition were determined on 20 nonbreathing human fetuses and abortuses ranging in gestational age from 2 to 9 months and are compatible with the hypothesis that hyaline membrane disease is due to a prenatal deficiency of lung surfactant.
Journal ArticleDOI
Beagle Dog Pulmonary Surfactant Lipids: Lipid Composition of Pulmonary Tissue, Exfoliated Lining Cells, and Surfactant
TL;DR: The lipids from normal beagle dog lungs, pulmonary surfactant, and exfoliated lining cells were quantitated by established procedures and cholesterol and its esters accounted for more than 60% of the neutral lipid fractions.