Journal ArticleDOI
Amelioration of intracerebroventricular streptozotocin induced cognitive dysfunction and oxidative stress by vinpocetine — a PDE1 inhibitor
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TLDR
The observed beneficial effects of vinpocetine on spatial memory may be due to its ability to favorably modulate cholinergic functions, prevent neuronal cell damage and possibly through its antioxidant mechanism also.About:
This article is published in European Journal of Pharmacology.The article was published on 2009-10-12. It has received 168 citations till now. The article focuses on the topics: Vinpocetine & Morris water navigation task.read more
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Emerging neuroprotective strategies for the treatment of ischemic stroke: An overview of clinical and preclinical studies.
TL;DR: There is still a substantial need for the development of therapeutic agents for neuroprotection in acute ischemic stroke to protect the brain from damage prior to and during recanalization, extend the therapeutic time window for intervention and further improve functional outcome.
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Phosphodiesterases as Therapeutic Targets for Alzheimer's Disease
TL;DR: The data supporting the use of PDE inhibitors as cognitive enhancers are summarized and the possible mechanisms of action underlying these effects are discussed.
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What have we learned from the streptozotocin-induced animal model of sporadic Alzheimer’s disease, about the therapeutic strategies in Alzheimer’s research
TL;DR: The therapeutic strategies that have been tested until now on the STZ-icv animal model have been reviewed and the comparability of the drugs’ efficacy in this non-transgenic sAD model and the results from clinical trials on sAD patients, evaluated.
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The Role of Phytochemicals in the Treatment and Prevention of Dementia
TL;DR: The potential and actual therapeutic strategies for dementia in relation to the known mechanisms of dementia pathology are presented and plant extracts that have shown relevant mechanistic effects for dementia and promising clinical data, but require more evidence for their clinical efficacy and safety are presented.
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JNK: A Stress-Activated Protein Kinase Therapeutic Strategies and Involvement in Alzheimer’s and Various Neurodegenerative Abnormalities
TL;DR: An overview on implications and therapeutic strategies of JNK in neurodegenerative disorders is provided and the JNK pathway is considered to be a key regulator of various inflammatory pathways which are activated during normal aging and Alzheimer's disease therapy.
References
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Journal Article
Protein Measurement with the Folin Phenol Reagent
TL;DR: Procedures are described for measuring protein in solution or after precipitation with acids or other agents, and for the determination of as little as 0.2 gamma of protein.
Book
The Rat Brain in Stereotaxic Coordinates
George Paxinos,Charles Watson +1 more
TL;DR: This paper presents a meta-analyses of the determinants of earthquake-triggered landsliding in the Czech Republic over a period of 18 months in order to establish a probabilistic framework for estimating the intensity of the earthquake.
Journal ArticleDOI
Tissue sulfhydryl groups
TL;DR: A water-soluble (at pH 8) aromatic disulfide [5,5′-dithiobis(2-nitrobenzoic acid] has been synthesized and shown to be useful for determination of sulfhydryl groups.
Journal ArticleDOI
A new and rapid colorimetric determination of acetylcholinesterase activity.
TL;DR: A photometric method for determining acetylcholinesterase activity of tissue extracts, homogenates, cell suspensions, etc., has been described and Kinetic constants determined by this system for erythrocyte eholinesterases are presented.
Journal ArticleDOI
Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids
Laura C. Green,David A. Wagner,Joseph A. Glogowski,Paul L. Skipper,John S. Wishnok,Steven R. Tannenbaum +5 more
TL;DR: A new automated system for the analysis of nitrate via reduction with a high-pressure cadmium column that automatically eliminates interference from other compounds normally present in urine and other biological fluids is described.