Journal ArticleDOI
An assessment of clinically useful measures of the consequences of treatment.
TLDR
The goal is to provide a clear picture of the individual components of the immune system and provide a strategy for individualized treatment of these components according to their Kesslerian importance.Abstract:
WITH neither the time nor the resources available to prevent, detect, or treat every disorder in every patient, which preventive, diagnostic, or therapeutic interventions should take priority? Whenread more
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Book
Cochrane Handbook for Systematic Reviews of Interventions
Julian P T Higgins,Sally Green +1 more
TL;DR: The Cochrane Handbook for Systematic Reviews of Interventions is the official document that describes in detail the process of preparing and maintaining Cochrane systematic reviews on the effects of healthcare interventions.
Journal ArticleDOI
Beneficial effect of carotid endarterectomy in symptomatic patients with high-grade carotid stenosis
Barnett Hjm.,D W Taylor,Richard Haynes,David L. Sackett,Sydney J. Peerless,Gary G. Ferguson,Allan J. Fox,R N Rankin,Vladimir Hachinski,Wiebers Do,Michael Eliasziw +10 more
TL;DR: Carotid endarterectomy is highly beneficial to patients with recent hemispheric and retinal transient ischemic attacks or nondisabling strokes and ipsilateral high-grade stenosis of the internal carotid artery.
Journal ArticleDOI
A Modified Poisson Regression Approach to Prospective Studies with Binary Data
TL;DR: Results from a limited simulation study indicate that this approach is very reliable even with total sample sizes as small as 100, and the method is illustrated with two data sets.
Journal ArticleDOI
CONSORT 2010 Explanation and Elaboration: updated guidelines for reporting parallel group randomised trials
David Moher,Sally Hopewell,Kenneth F. Schulz,Victor M. Montori,Peter C Gøtzsche,Philip J. Devereaux,Diana Elbourne,Matthias Egger,Douglas G. Altman +8 more
TL;DR: This update of the CONSORT statement improves the wording and clarity of the previous checklist and incorporates recommendations related to topics that have only recently received recognition, such as selective outcome reporting bias.
Journal ArticleDOI
Evidence-Based Medicine: A New Approach to Teaching the Practice of Medicine
Gordon H. Guyatt,John A. Cairns,David N. Churchill,Deborah J. Cook,Brian Haynes,Jack Hirsh,Jan Irvine,Mark Levine,Mitchell Levine,Jim Nishikawa,David L. Sackett,Patrick Brill-Edwards,Hertzel C. Gerstein,James L. Gibson,Roman Jaeschke,Anthony Kerigan,Alan J. Neville,Akbar Panju,Allan S. Detsky,Murray Enkin,Pamela Frid,Martha S. Gerrity,Andreas Laupacis,Valerie A. Lawrence,Joël Ménard,Virginia Moyer,Cynthia D. Mulrow,Paul Links,Andrew D Oxman,Jack Sinclair,Peter Tugwell +30 more
TL;DR: An important goal of the medical residency program is to educate physicians in the practice of evidence-based medicine, and strategies include a weekly, formal academic half-day for residents devoted to learning the necessary skills.
References
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Journal ArticleDOI
Beta blockade during and after myocardial infarction: an overview of the randomized trials
TL;DR: The aim has been not only to review the 65-odd randomized beta blocker trials but also to demonstrate that when many randomized trials have all applied one general approach to treatment, it is often not appropriate to base inference on individual trial results.
Journal ArticleDOI
REDUCTION IN MORTALITY FROM BREAST CANCER AFTER MASS SCREENING WITH MAMMOGRAPHY: Randomised Trial from the Breast Cancer Screening Working Group of the Swedish National Board of Health and Welfare
Laszlo Tabar,Laszlo Tabar,Laszlo Tabar,Adel Gad,Adel Gad,Adel Gad,L. H. Holmberg,L. H. Holmberg,L. H. Holmberg,U. Ljungquist,U. Ljungquist,U. Ljungquist,C.J.G Fagerberg,C.J.G Fagerberg,C.J.G Fagerberg,L. Baldetorp,L. Baldetorp,L. Baldetorp,O Gröntoft,O Gröntoft,O Gröntoft,B. Lundström,B. Lundström,B. Lundström,J. C. Månson,J. C. Månson,J. C. Månson,Gunnar Eklund,Gunnar Eklund,Gunnar Eklund,N.E Day,N.E Day,N.E Day,F. Pettersson,F. Pettersson,F. Pettersson +35 more
TL;DR: 7 years after the start of the study the excess of stage I cancers in the study group largely outweighs the deficit of advanced cancers, and the results to the end of 1984 show a 31% reduction in mortality from breast cancer and a 25% reduced in the rate of stage II or more advanced breast cancers.
Journal Article
Effects of treatment on morbidity in hypertension. Results in patients with diastolic blood pressures averaging 115 through 129mmHg
Journal ArticleDOI
Hepatitis B vaccine: demonstration of efficacy in a controlled clinical trial in a high-risk population in the United States.
Wolf Szmuness,Cladd E. Stevens,Edward J. Harley,Edith A. Zang,William R. Oleszko,Daniel C. William,Richard Sadovsky,John Morrison,Aaron Kellner +8 more
TL;DR: In this article, the efficacy of an inactivated hepatitis B vaccine in a randomized, double-blind trial in 1083 homosexual men known to be at high risk for hepatitis B virus infection was evaluated.
Journal ArticleDOI
Non-smoking wives of heavy smokers have a higher risk of lung cancer: a study from Japan.
TL;DR: The results indicate the possible importance of passive or indirect smoking as one of the causal factors of lung cancer and appear to explain the long-standing riddle of why many women develop lung cancer although they themselves are non-smokers.
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