Journal ArticleDOI
An efficient copper-catalyzed coupling of aryl halides with imidazoles
TLDR
Copper-catalyzed Narylation of imidazoles can be accomplished using (CuOTf)2·benzene as a copper source and Cs2CO3 as a base in xylenes at 110-125 °C as mentioned in this paper.About:
This article is published in Tetrahedron Letters.The article was published on 1999-04-02. It has received 356 citations till now. The article focuses on the topics: Aryl & Copper.read more
Citations
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Journal ArticleDOI
Aryl-aryl bond formation one century after the discovery of the Ullmann reaction.
Journal ArticleDOI
Heterocyclic Carbenes: Synthesis and Coordination Chemistry
TL;DR: New methods for the synthesis of complexes with N-heterocyclic carbene ligands such as the oxidative addition or the metal atom template controlled cyclized isocyanides have been developed recently.
Journal ArticleDOI
Selected patented cross-coupling reaction technologies.
Journal ArticleDOI
Catalytic C-C, C-N, and C-O Ullmann-type coupling reactions.
Florian Monnier,Marc Taillefer +1 more
TL;DR: An increasing number of publications have appeared concerning Ullmann-type intermolecular reactions for the coupling of aryl and vinyl halides with N, O, and C nucleophiles, and this Minireview highlights recent and major developments in this topic since 2004.
Journal ArticleDOI
Copper in cross-coupling reactions: The post-Ullmann chemistry
TL;DR: A number of methods using various copper complexes and salts to carry out cross-coupling reactions leading to the formation of C heteroatom (C N, C O, C S, C P, C Se), C C, and C metal bonds have been proposed as discussed by the authors.
References
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Journal ArticleDOI
A general copper-catalyzed synthesis of diaryl ethers
Journal ArticleDOI
Highly selective inhibitors of thromboxane synthetase. 1. Imidazole derivatives
Kinji Iizuka,Kenji Akahane,D. Momose,M. Nakazawa,T. Tanouchi,Masanori Kawamura,I. Ohyama,I. Kajiwara,Y. Iguchi,T. Okada,K. Taniguchi,T. Miyamoto,Masaki Hayashi +12 more
TL;DR: The structure-activity relationship of imidazole derivatives as inhibitors of thromboxane (TX) synthetase was investigated in this article, where various substituents (e.g., one or two methyl groups, a halogen atom, a methylidene group, unsaturated bonds, or a phenylene group) into the alpha position or other positions in the carboxy-bearing side chain of 1-(7-carboxyheptyl)imidazoles were found to increase the inhibitory potency.
Journal ArticleDOI
New synthetic applications of aryllead triacetates. N-arylation of azoles.
Journal ArticleDOI
Inhibitors of cyclic AMP phosphodiesterase. 3. Synthesis and biological evaluation of pyrido and imidazolyl analogues of 1,2,3,5-tetrahydro-2-oxoimidazo[2,1-b]quinazoline.
TL;DR: Evaluation of the design and synthesis of the title compounds suggest that access to a secondary, lipophilic-tolerant binding site, possibly coincident with the adenine binding domain, and adjacent to the catalytic ribose-phosphate binding site of platelet and cardiac type IV PDE, is responsible for the increased potency of these compounds.
Related Papers (5)
Modern Synthetic Methods for Copper‐Mediated C(aryl) ? O, C(aryl) ? N, and C(aryl) ? S Bond Formation
Steven V. Ley,Andrew Thomas +1 more