Journal ArticleDOI
An electrophysiological study of the action of methylmercuric chloride and mercuric chloride on the sciatic nerve-sartorius muscle preparation of the frog.
TLDR
It may be concluded that the primary action of CH 3 HgCl is on the presynaptic site, whereas that of H gCl 2 is both on the pre-and postsynaptic sites, and that either spontaneous or evoked transmitter release was similarly suppressed after long-term exposure.About:
This article is published in Toxicology and Applied Pharmacology.The article was published on 1976-08-01. It has received 69 citations till now. The article focuses on the topics: Neuromuscular transmission & Resting potential.read more
Citations
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Journal ArticleDOI
Mechanism of methylmercury cytotoxicity
TL;DR: The aim of this article is to review the recent studies on the toxicity of methylmercury at the cellular level and to outline the mechanisms which have been proposed to be responsible for cell injuries.
Journal ArticleDOI
Disruption of intraneuronal divalent cation regulation by methylmercury: are specific targets involved in altered neuronal development and cytotoxicity in methylmercury poisoning?
TL;DR: The hypothesis that MeHg affects specific targets to cause disruption of neuronal development and cell death is examined.
Journal ArticleDOI
Hg2+ causes neurotoxicity at an intracellular site following entry through Na and Ca channels
TL;DR: The results suggest that metals may inhibit transmitter release at either the Ca channel or at the release site, but that irreversible toxicity is due to an intracellular action, possibly involving SH groups.
BookDOI
Cerebral energy metabolism and metabolic encephalopathy
TL;DR: Books and internet are the recommended media to help you improving your quality and performance.
Journal ArticleDOI
Mercury modulation of GABA-activated chloride channels and non-specific cation channels in rat dorsal root ganglion neurons
TL;DR: The effects of mercuric chloride and methylmercury chloride on the rat dorsal root ganglion neurons in primary culture were studied by the whole-cell patch clamp technique and were likely to be due to non-specific cation channels.
References
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Journal ArticleDOI
Spontaneous subthreshold activity at motor nerve endings
P. Fatt,Bernard Katz +1 more
TL;DR: The present study arose from the chance observation that end-plates of resting muscle fibres are the seat of spontaneous electric discharges which have the character of miniature end-plate potentials.
Journal ArticleDOI
An analysis of the end‐plate potential recorded with an intra‐cellular electrode
P. Fatt,Bernard Katz +1 more
TL;DR: The immediate concern of the present work is to determine the electric charge which passes through the end-plate membrane during the transmission of one impulse and to throw some light on the mechanism by which the transfer of ions across theend-plate is brought about.
Journal ArticleDOI
The nature of the neuromuscular block produced by magnesium.
J. del Castillo,Lise Engbaek +1 more
TL;DR: The object of this work was to provide information on the mechanism of action of magnesium at the neuromuscular junction, by studying separately, as far as was possible, its effect on each of the different stages of the process of impulse transmission from nerve to muscle.
Journal ArticleDOI
On the factors which determine the amplitude of the miniature end-plate potential.
B. Katz,S. Thesleff +1 more
Journal ArticleDOI
Effect of Lanthanum Ions on Function and Structure of Frog Neuromuscular Junctions
John E. Heuser,Ricardo Miledi +1 more
TL;DR: Electrophysiological and electron-microscopic studies were made of the effect of lanthanum ions on frog neuromuscular junctions, finding that with continued La-treatment, the frequency of miniature end-plate potentials subsides slowly until they are no longer detectable at most end-plates.
Related Papers (5)
Evoked transmitter release increased by inorganic mercury at frog neuromuscular junction.
R. S. Manalis,G. P. Cooper +1 more
Hg2+ causes neurotoxicity at an intracellular site following entry through Na and Ca channels
Methylmercury-induced depression of neuromuscular transmission in the rat.
W. D. Atchison,Toshio Narahashi +1 more