An Update on Treatment of Genotype 1 Chronic Hepatitis C Virus Infection: 2011 Practice Guideline by the American Association for the Study of Liver Diseases
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TLDR
The standard of care (SOC) therapy for patients with chronic hepatitis C virus (HCV) infection has been the use of both peginterferon (PegIFN) and ribavirin (RBV) as mentioned in this paper.About:
This article is published in Hepatology.The article was published on 2011-10-01 and is currently open access. It has received 1117 citations till now. The article focuses on the topics: Boceprevir & Telaprevir.read more
Citations
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Journal ArticleDOI
Sofosbuvir for previously untreated chronic hepatitis C infection
Eric Lawitz,Alessandra Mangia,David L. Wyles,Maribel Rodriguez-Torres,Tarek Hassanein,Stuart C. Gordon,Michael Schultz,M. Davis,Zeid Kayali,K. Rajender Reddy,Ira M. Jacobson,Kris V. Kowdley,L. Nyberg,G. Mani Subramanian,Robert H. Hyland,Sarah Arterburn,Deyuan Jiang,John McNally,Diana M. Brainard,William T. Symonds,John G. McHutchison,Aasim Sheikh,Zobair M. Younossi,Edward Gane +23 more
TL;DR: In a single-group study of sofosbuvir combined with peginterferon-ribavirin, patients with predominantly genotype 1 or 4 HCV infection had a rate of sustained virologic response of 90% at 12 weeks.
Journal ArticleDOI
Next Generation of Fluorine-Containing Pharmaceuticals, Compounds Currently in Phase II–III Clinical Trials of Major Pharmaceutical Companies: New Structural Trends and Therapeutic Areas
Yu Zhou,Jiang Wang,Zhanni Gu,Shuni Wang,Wei Zhu,José Luis Aceña,Vadim A. Soloshonok,Kunisuke Izawa,Hong Liu +8 more
TL;DR: Compounds Currently in Phase II−III Clinical Trials of Major Pharmaceutical Companies: New Structural Trends and Therapeutic Areas is presented.
Journal ArticleDOI
Ledipasvir and Sofosbuvir for Untreated HCV Genotype 1 Infection
Nezam H. Afdhal,Stefan Zeuzem,Paul Y. Kwo,Mario Chojkier,Norman Gitlin,Massimo Puoti,Manuel Romero-Gómez,Jean-Pierre Zarski,Kosh Agarwal,Peter Buggisch,Graham R. Foster,Norbert Bräu,Maria Buti,Ira M. Jacobson,G. Mani Subramanian,Xiao Ding,Hongmei Mo,Jenny C. Yang,Phillip S. Pang,William T. Symonds,John G. McHutchison,Andrew J. Muir,Alessandra Mangia,Patrick Marcellin +23 more
TL;DR: Once-daily ledipasvir-sofosbuvir with or without ribavirin for 12 or 24 weeks was highly effective in previously untreated patients with HCV genotype 1 infection.
Recommendations for the identification of chronic hepatitis C virus infection among persons born during 1945-1965.
Bryce D. Smith,Rebecca L. Morgan,Geoff A. Beckett,Yngve Falck-Ytter,Deborah Holtzman,Chong-Gee Teo,Amy Jewett,Brittney Baack,David B. Rein,Nita Patel,Miriam J. Alter,Anthony Yartel,John W. Ward +12 more
TL;DR: Targeted testing and linkage to care for infected persons in this birth cohort is expected to reduce HCV-related morbidity and mortality and help halt disease progression and provide a virologic cure.
Journal ArticleDOI
Eradication of Hepatitis C Virus Infection and the Development of Hepatocellular Carcinoma: A Meta-analysis of Observational Studies
Rebecca L. Morgan,Brittney Baack,Bryce D. Smith,Anthony Yartel,Marc Pitasi,Yngve Falck-Ytter +5 more
TL;DR: A systematic review of the evidence is needed to assess the benefits of treatment of hepatitis C virus (HCV)-infected persons on development of hepatocellular carcinoma (HCC).
References
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Journal Article
Genetic variation in IL-28B and spontaneous clearance of hepatitis C virus
TL;DR: Patients who spontaneously cleared HCV were younger than chronically infected group;spontaneous clearance rate of rs12979860 genotype CC/CT,rs8099917 genotype TT/TG,rs10853728 genotypes CC/CG and rs12980275 genotype AA/AG were not significantly different; however, the age of infection was associated with spontaneous clearance.
Journal ArticleDOI
Amino acid substitution in hepatitis C virus core region and genetic variation near the interleukin 28B gene predict viral response to telaprevir with peginterferon and ribavirin
Norio Akuta,Fumitaka Suzuki,Miharu Hirakawa,Yusuke Kawamura,Hiromi Yatsuji,Hitomi Sezaki,Yoshiyuki Suzuki,Tetsuya Hosaka,Masahiro Kobayashi,Mariko Kobayashi,Satoshi Saitoh,Yasuji Arase,Kenji Ikeda,Kazuaki Chayama,Yusuke Nakamura,Hiromitsu Kumada +15 more
TL;DR: Analysis of genetic variation near the IL28B gene and aa substitution of the core region as predictors of sustained virological response to a triple therapy of telaprevir/PEG‐IFN/ribavirin in Japanese patients infected with HCV genotype 1b identified high sensitivity, specificity, and positive and negative predictive values.
Journal ArticleDOI
Sustained virologic response prevents the development of esophageal varices in compensated, child-pugh class A hepatitis C virus-induced cirrhosis. A 12-year prospective follow-up study
Savino Bruno,Andrea Crosignani,C. Facciotto,Sonia Rossi,Luigi Roffi,Alessandro Redaelli,Roberto de Franchis,Piero Luigi Almasio,Patrick Maisonneuve +8 more
TL;DR: In the long term, the achievement of SVR prevents the development of EV in patients with compensated HCV‐induced cirrhosis, and in these patients, endoscopic surveillance can be safely delayed or avoided.
Journal ArticleDOI
1369 telaprevir substantially improved svr rates across all il28b genotypes in the advance trial
Ira M. Jacobson,I. Catlett,Patrick Marcellin,Natalie Bzowej,Andrew J. Muir,N. Adda,Leif Bengtsson,Shelley George,S. Seepersaud,R. Ramachandran,K. Sussky,Robert S. Kauffman,Martyn Botfield +12 more
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12 il28b polymorphism predicts virologic response in patients with hepatitis c genotype 1 treated with boceprevir (boc) combination therapy
Fred Poordad,Jean-Pierre Bronowicki,S.C. Gordon,S. Zeuzem,Ira M. Jacobson,M.S. Sulkowski,Thierry Poynard,Timothy R. Morgan,Margaret Burroughs,Vilma Sniukiene,Navdeep Boparai,Clifford A. Brass,Janice K. Albrecht,Bruce R. Bacon +13 more
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Telaprevir for Previously Untreated Chronic Hepatitis C Virus Infection
Ira M. Jacobson,John G. McHutchison,Geoffrey Dusheiko,Adrian M. Di Bisceglie,K. Rajender Reddy,Natalie Bzowej,Patrick Marcellin,Andrew J. Muir,Peter Ferenci,Robert Flisiak,Jacob George,Mario Rizzetto,Daniel Shouval,Ricard Sola,R. Terg,Eric M. Yoshida,Nathalie Adda,Leif Bengtsson,Abdul J. Sankoh,Tara L. Kieffer,Shelley George,Robert S. Kauffman,Stefan Zeuzem,Vertex Phar +23 more