Journal ArticleDOI
Anaesthesia by the n-alkanes. A comparative study of nerve impulse blockage and the properties of black lipid bilayer membranes.
TLDR
A close correlation is shown to exist between the nerve results and those for a phosphaytidylcholine-cholesterol bilayer, suggesting that the site of action of the alkane is in a lipid bilayer region of the nerve mumbrane, which reduces the stability of the ionic channels formed during electrical excitation.About:
This article is published in Biochimica et Biophysica Acta.The article was published on 1977-10-03. It has received 121 citations till now. The article focuses on the topics: Bilayer & Lipid bilayer.read more
Citations
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Journal ArticleDOI
Predicting skin permeability.
Russell O. Potts,Richard H. Guy +1 more
TL;DR: A facile interpretation of a considerable body of skin permeability measurements is presented that very adequately describes the dependence of Kp upon permeant size and lipophilicity, generates parameters of considerable physicochemical and mechanistic relevance, and implies that the SC lipids alone can fully characterize the barrier properties of mammalian skin.
Journal ArticleDOI
Inorganic mercury (Hg2+) transport through lipid bilayer membranes
TL;DR: In this article, the authors studied the diffusion of inorganic mercury (Hg2+) through planar lipid bilayer membranes as a function of chloride concentration and pH, and they found that at Cl− concentrations ranging from 1−100mm, diffusion of HgCl2 through the unstirred layer is rate limiting.
Journal ArticleDOI
The organization of n-alkanes in lipid bilayers
TL;DR: The interaction of n-alkanes (C6--C16) with phosphatidylcholine has been studied by the combined use of differential scanning calorimetry, X-ray diffraction and monolayer techniques and it has been found that the thermal properties and ultrastructure of lipid-alkane vesicles are strongly dependent on the length of the n-alksanes.
Book ChapterDOI
The nature of the site of general anesthesia.
TL;DR: The study of these anesthetic mechanisms is in a transition between thermodynamic and molecular explanations, as it has become more clear that average lipid parameters are less likely to be related to membrane protein function than are the detailed heterogeneous arrangement of lipids and proteins.
Journal ArticleDOI
Degenerate perturbations of protein structure as the mechanism of anaesthetic action.
C. D. Richards,K. Martin,S. Gregory,C. A. Keightley,T R Hesketh,Gerry A. Smith,G. B. Warren,J C Metcalfe +7 more
TL;DR: The interaction of the n-alkanols with lipid bilayers and excitable membranes shows that there is no simple correlation between conduction block and any of the perturbations of bilayer structure currently proposed as unitary mechanisms of local anaesthetic action.
References
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Journal Article
The Membrane Actions of Anesthetics and Tranquilizers
TL;DR: A diagrammatic summary of the membrane actions of anesthetics and tran-quilizers is shown, and the membrane fluidization may explain the enhanced neurosecretion of membrane-bound materials, by a mechanism of membranes-membrane fusion.
Journal ArticleDOI
The action of calcium on the electrical properties of squid axons
B. Frankenhaeuser,A. L. Hodgkin +1 more
Journal ArticleDOI
Ion transfer across lipid membranes in the presence of gramicidin A: I. Studies of the unit conductance channel
Stephen B. Hladky,D.A. Haydon +1 more
TL;DR: The conductance induced by gramicidin A in lipid bilayer membranes has been shown to be made up of discrete, well-defined units and it has been concluded that the conducting channel is a pore, rather than a carrier.
Journal ArticleDOI
Ion transport across thin lipid membranes: a critical discussion of mechanisms in selected systems.
D.A. Haydon,Stephen B. Hladky +1 more
TL;DR: In this paper, a review of the role of 1-carriets in the transfer of ions across thin lipid bilayer membranes is presented, focusing on simpler systems, i.e., the lipid-soluble ions, the 1-1 carriets, a simple pore and a substance which prodeces interacting pores.