Anemia of inflammation
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TLDR
Based on experience with anemia treatment in chronic kidney disease, critical illness, and cancer, finding the appropriate indications for the specific treatment of AI will require improved understanding and a balanced consideration of the contribution of anemia to each patient's morbidity and the impact of anemic treatment on the patient's prognosis in a variety of disease settings.About:
This article is published in Blood.The article was published on 2019-01-03 and is currently open access. It has received 537 citations till now. The article focuses on the topics: Anemia of chronic disease & Anemia.read more
Citations
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Journal ArticleDOI
Iron metabolism and iron disorders revisited in the hepcidin era
TL;DR: Improved understanding of iron homeostasis and its regulation is leading to the development of targeted therapies for iron overload and inflammation, mainly centered on the manipulation of the hepcidin-ferroportin axis.
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Anemia and iron metabolism in COVID-19: a systematic review and meta-analysis.
Petek Eylul Taneri,Sergio Alejandro Gómez-Ochoa,Erand Llanaj,Erand Llanaj,Peter Francis Raguindin,Peter Francis Raguindin,Lyda Z. Rojas,Zayne Milena Roa-Díaz,Dante Salvador,Dion Groothof,Beatrice Minder,Doris Kopp-Heim,Wolf E. Hautz,Michele F Eisenga,Oscar H. Franco,Marija Glisic,Taulant Muka +16 more
TL;DR: A systematic review and meta-analysis to evaluate biomarkers of anemia and iron metabolism in patients diagnosed with COVID-19 and explored their prognostic value found that hemoglobin levels were lower with older age, higher percentage of subjects with diabetes, hypertension and overall comorbidities, and admitted to intensive care.
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Iron deficiency anaemia revisited
TL;DR: This review provides recent updates and guidance on the diagnosis and management of iron deficiency anaemia in multiple clinical settings.
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Therapeutic versus prophylactic anticoagulation for severe COVID-19: A randomized phase II clinical trial (HESACOVID).
Anna Cristina Bertoldi Lemos,Douglas Alexandre do Espírito Santo,Maísa Cabetti Salvetti,Renato Noffs Gilio,Lucas Barbosa Agra,Antonio Pazin-Filho,Carlos Henrique Miranda +6 more
TL;DR: Therapeutic enoxaparin improves gas exchange and decreases the need for mechanical ventilation in severe COVID–19 patients requiring mechanical ventilation.
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Preoperative intravenous iron to treat anaemia before major abdominal surgery (PREVENTT): a randomised, double-blind, controlled trial.
Toby Richards,Toby Richards,Ravishankar Rao Baikady,Ben Clevenger,Anna Butcher,Sandy Abeysiri,Marisa Chau,Iain C. Macdougall,Gavin J. Murphy,Rebecca Swinson,Timothy Collier,Laura Van Dyck,John Browne,Andrew W. Bradbury,Matthew Dodd,Richard Evans,David Brealey,Stefan D. Anker,Andrew A. Klein +18 more
TL;DR: Preoperative intravenous iron was not superior to placebo to reduce need for blood transfusion when administered to patients with anaemia 10–42 days before elective major abdominal surgery.
References
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Hepcidin Regulates Cellular Iron Efflux by Binding to Ferroportin and Inducing Its Internalization
Elizabeta Nemeth,Marie S. Tuttle,Julie Powelson,Michael B. Vaughn,Adriana Donovan,Diane M. Ward,Tomas Ganz,Jerry Kaplan +7 more
TL;DR: It is reported that hepcidin bound to ferroportin in tissue culture cells, leading to decreased export of cellular iron and the posttranslational regulation of ferroports by hePCidin may complete a homeostatic loop.
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Anemia of Chronic Disease
TL;DR: Advances in knowledge of the causes and management of the anemia of chronic disease are discussed.
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IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin
Elizabeta Nemeth,Seth Rivera,Victoria Gabayan,Charlotte Keller,Sarah Taudorf,Bente Klarlund Pedersen,Tomas Ganz +6 more
TL;DR: These studies in human liver cell cultures, mice, and human volunteers indicate that IL-6 is the necessary and sufficient cytokine for the induction of hepcidin during inflammation and that the IL- 6-hepcid in axis is responsible for the hypoferremia of inflammation.
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Ferric Carboxymaltose in Patients with Heart Failure and Iron Deficiency.
Stefan D. Anker,Josep Comin Colet,Gerasimos Filippatos,Ronnie Willenheimer,Kenneth Dickstein,Helmut Drexler,Thomas F. Lüscher,Boris Bart,Waldemar Banasiak,Joanna Niegowska,Bridget Anne Kirwan,Claudio Mori,Barbara von Eisenhart Rothe,Stuart J. Pocock,Philip A. Poole-Wilson,Piotr Ponikowski +15 more
TL;DR: Treatment with intravenous ferric carboxymaltose in patients with chronic heart failure and iron deficiency, with or without anemia, improves symptoms, functional capacity, and quality of life; the side-effect profile is acceptable.
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The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation
Gaël Nicolas,Caroline Chauvet,Lydie Viatte,Jean Louis Danan,Xavier Bigard,Isabelle Devaux,Carole Beaumont,Axel Kahn,Sophie Vaulont +8 more
TL;DR: Modifications of hepcidin gene expression suggest a key role for hepciridin in iron homeostasis under various pathophysiological conditions, which may support the pharmaceutical use of hePCidin agonists and antagonists in various ironHomeostasis disorders.