Journal ArticleDOI
Anti-HIV Securinega alkaloid oligomers from Flueggea virosa
TLDR
An MS guided fractionation of the alkaloidal constituents of Flueggea virosa has yielded nine new Securinega alkaloid oligomers, fluevirosinines B-J ( 1 − 9 ). The absolute structures of these oligomers were characterized on the basis of spectroscopic data and biogenetic consideration as discussed by the authors.About:
This article is published in Tetrahedron.The article was published on 2015-06-03. It has received 24 citations till now. The article focuses on the topics: Securinega.read more
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An Accelerated Intermolecular Rauhut–Currier Reaction Enables the Total Synthesis of (−)-Flueggenine C
Sangbin Jeon,Sunkyu Han +1 more
TL;DR: It is found that installation of a nucleophilic functional group at the γ-position of an enone greatly accelerates the rate of the diastereoselective intermolecular RC reaction, enabling an efficient and selective formation of the dimeric intermediate which was further transformed to (-)-flueggenine C.
Journal ArticleDOI
Flueggether A and Virosinine A, Anti-HIV Alkaloids from Flueggea virosa.
TL;DR: Two new alkaloids, flueggether A and virosinine A, were isolated from a Chinese medicinal plant, Flueggea virosa, and showed mild in vitro anti-HIV activity.
Journal ArticleDOI
Limonoids with Anti-HIV Activity from Cipadessa cinerascens.
TL;DR: Sixteen new limonoids, named ciparasins A-P (1-16), comprising three structural categories of trijugin-type, cipadesin- Type (8-15), and prieurianin- type (16) compounds, as well as 15 known limonoid analogues, were isolated from Cipadessa cinerascens.
Journal ArticleDOI
Ethnomedicinal plants used by traditional healers in the management of HIV/AIDS opportunistic diseases in Lusaka, Zambia
TL;DR: A fundamental rethink of how patients and public health authorities view traditional plant medicines for HIV/AIDS management in Lusaka, Zambia is urged.
Journal ArticleDOI
Fluvirosaones A and B, Two Indolizidine Alkaloids with a Pentacyclic Skeleton from Flueggea virosa
Xiang-Kun Luo,Jie Cai,Zhi-Yong Yin,Pan Luo,Chanjuan Li,Hang Ma,Navindra P. Seeram,Qiong Gu,Jun Xu +8 more
TL;DR: Two compounds isolated from Flueggea virosa represent the first examples of a pentacyclic Securinega alkaloid containing a pentACYclic system and an α,β-unsaturated ketone.
References
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Journal ArticleDOI
Tetrazolium-based colorimetric assay for the detection of HIV replication inhibitors: revisited 20 years later
TL;DR: The long-standing and intensive use of the MTT method has taught users of the limitations and the unexpected advantages of the MT-4/MTT assay, and this method can be extended to antiviral testing of compounds against other cyto-destructive viruses.
Journal ArticleDOI
Total syntheses of the Securinega alkaloids (+)-14,15-dihydronorsecurinine, (-)-norsecurinine, and phyllanthine.
TL;DR: A new strategy for enantiospecific construction of the Securinega alkaloids has been developed and applied in total syntheses of (+)-14,15-dihydronorsecurinine (8), (-)-norsecur inine (6), and phyllanthine.
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Virosaines A and B, two new birdcage-shaped Securinega alkaloids with an unprecedented skeleton from Flueggea virosa.
Bing-Xin Zhao,Ying Wang,Dong-Mei Zhang,Xiao-Jun Huang,Liang-Liang Bai,Yan Yan,Chen Jiamei,Lu Tongbu,Yitao Wang,Qing-Wen Zhang,Wen-Cai Ye +10 more
TL;DR: Two new Securinega alkaloids, virosaines A (1) and B (2), were isolated from the twigs and leaves of Flueggea virosa and represent the first examples of Securines bearing a 7-oxa-1-azabicyclo[3.2.1]octane ring system.
Journal ArticleDOI
Flueggines A and B, Two New Dimeric Indolizidine Alkaloids from Flueggea virosa
Bing-Xin Zhao,Ying Wang,Dong-Mei Zhang,Ren-Wang Jiang,Guo-Cai Wang,Jun-Min Shi,Xiao-Jun Huang,Wei-Min Chen,Chun-Tao Che,Wen-Cai Ye +9 more
TL;DR: Two unprecedented C,C-linked dimeric indolizidine alkaloids, flueggines A and B, were isolated from the twigs and leaves of Flueggea virosa and exhibited growth inhibitory activity against MCF-7 and MDA-MB-231 human breast cancer cells.
Journal ArticleDOI
Stereoselective Total Syntheses of (−)-Flueggine A and (+)-Virosaine B†
TL;DR: The total syntheses of (-)-flueggine A and (+)-virosaine B have been accomplished in a concise and convergent manner using relay ring-closing metathesis reactions for rapid construction of the key intermediates, and 1,3-dipolar cycloaddition reactions for the formation of the natural products.