Journal ArticleDOI
Antibacterial activity and QSAR of chalcones against biofilm-producing bacteria isolated from marine waters
TLDR
The in vitro antifouling activity of 47 synthesized chalcone derivatives was investigated by estimating the minimum inhibitory concentration against these organisms using a twofold dilution technique and spatial, structural and electronic descriptors were found to be predominantly affecting the antibacterial activity of these compounds.Abstract:
Biofouling in the marine environment is a major problem. In this study, three marine organisms, namely Bacillus flexus (LD1), Pseudomonas fluorescens (MD3) and Vibrio natriegens (MD6), were isolated from biofilms formed on polymer and metal surfaces immersed in ocean water. Phylogenetic analysis of these three organisms indicated that they were good model systems for studying marine biofouling. The in vitro antifouling activity of 47 synthesized chalcone derivatives was investigated by estimating the minimum inhibitory concentration against these organisms using a twofold dilution technique. Compounds C-5, C-16, C-24, C-33, C-34 and C-37 were found to be the most active. In the majority of the cases it was found that these active compounds had hydroxyl substitutions. A quantitative structure-activity relationship (QSAR) was developed after dividing the total data into training and test sets. The statistical measures r(2), [image omitted] (>0.6) q(2) (>0.5) and the F-ratio were found to be satisfactory. Spatial, structural and electronic descriptors were found to be predominantly affecting the antibiofouling activity of these compounds. Among the spatial descriptors, Jurs descriptors showed their contribution in all the three antibacterial QSARs.read more
Citations
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Predicted Relative Metabolomic Turnover (PRMT): determining metabolic turnover from a coastal marine metagenomic dataset
Peter E. Larsen,Frank R. Collart,Dawn Field,Folker Meyer,Kevin P. Keegan,Christopher S. Henry,Christopher S. Henry,John W. McGrath,John P. Quinn,Jack A. Gilbert,Jack A. Gilbert +10 more
TL;DR: The PRMT method was successfully applied to metagenomic data to explore the Western English Channel microbial metabalome to generate specific, biologically testable hypotheses and can be applied as a general tool for the analysis of additional meetagenomic or transcriptomic datasets.
Biodegradation and corrosion behaviorof manganese oxidizer Bacillus cereus ACE4in diesel transporting pipeline
Aruliah Rajasekar,T. Ganesh Babu,S. Karuthapandian,Sundaram Maruthamuthu,N. Palaniswamy,Annamalai Rajendran +5 more
TL;DR: In this paper, the role of Bacillus cereus ACE4 on degradation of diesel and its influence on corrosion of API============5LX steel was investigated and a demonstrating bacterial strain ACE4 was isolated from corrosion products and 16S============RNA gene sequence analysis showed that it has more than 99% similarity with B. cereus.
Journal ArticleDOI
Polydimethyl siloxane nanocomposites: Their antifouling efficacy in vitro and in marine conditions
G. Gomathi Sankar,G. Gomathi Sankar,S. Sathya,S. Sathya,P. Sriyutha Murthy,A. Das,R. Pandiyan,Vayalam P. Venugopalan,Mukesh Doble +8 more
TL;DR: In this article, the authors incorporated metal oxide nanoparticles in polydimethyl siloxane (PDMS) matrix to create composites with enhanced antifouling properties, which were tested in vitro against a marine bacterium and a diatom.
Journal ArticleDOI
Synthesis and complete assignment of NMR data of 20 chalcones.
TL;DR: The syntheses of 20 chalcones and complete assignments of 1H and 13C NMR spectra are reported on.
Journal ArticleDOI
Biosurfactant from Pseudomonas species with waxes as carbon source – Their production, modeling and properties
TL;DR: In this article, the authors reported the production of biosurfactant from Pseudomonas aeruginosa and pseudomonas fluorescens with waxes namely, n-hexadecane and n-eicosane as carbon sources.
References
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Daniel F. Veber,Stephen R. Johnson,Hung-Yuan Cheng,Brian R. Smith,Keith W. Ward,Kenneth D. Kopple +5 more
TL;DR: Reduced molecular flexibility, as measured by the number of rotatable bonds, and low polar surface area or total hydrogen bond count are found to be important predictors of good oral bioavailability, independent of molecular weight.
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TL;DR: This Users guide notations acronyms list of molecular descriptors contains abbreviations for molecular descriptor values that are useful for counting and topological descriptors calculation.
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Initiation of biofilm formation in Pseudomonas fluorescens WCS365 proceeds via multiple, convergent signalling pathways: a genetic analysis
George A. O'Toole,Roberto Kolter +1 more
TL;DR: The genetic analyses suggest that biofilm formation can proceed via multiple, convergent signalling pathways, which are regulated by various environmental signals, and that of the 24 sad mutants analysed in this study, only three had defects in genes of known function.