Journal ArticleDOI
Antibody labeling with copper-67 using the bifunctional macrocycle 4-[(1,4,8,11-tetraazacyclotetradec-1-yl)methyl]benzoic acid
Peter Smith-Jones,Raimund Fridrich,Thomas A. Kaden,Ilse Novak-Hofer,Karl Siebold,Daniel Tschudin,Helmut R. Maecke +6 more
TLDR
The high kinetic stability of the Cu2+ complex of the chelator 4-[(1,4,8,11-tetraazacyclotetradec-1-yl)-methyl]benzoic acid was demonstrated at physiological pH as well as under acidic conditions.About:
This article is published in Bioconjugate Chemistry.The article was published on 1991-11-01. It has received 59 citations till now. The article focuses on the topics: Conjugate & Benzoic acid.read more
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Patent
Conjugated 4'-desmethyl nucleoside analog compounds
Phillip Dan Cook,Kelly Teng +1 more
TL;DR: Tetrahydrofuranyl compounds are provided that are functionalized to include pendant conjugate groups, and which are useful in diagnostic assays and as research reagents.
Patent
Thiol-derivatized nucleosides
TL;DR: In this article, the alkylthiol chemical functionality at ribofuranosyl positions, nucleosidic base positions, or on internucleoside linkages was described.
Patent
Derivatized oligonucleotides having improved uptake and other properties
TL;DR: Linked nucleosides having at least one functionalized nucleoside that bears a substituent such as a steroid molecule, a reporter molecule, non-aromatic lipophilic molecule, an enzyme, a peptide, a protein, a water soluble vitamin, a lipid soluble vitamin this article, an RNA cleaving complex, a metal chelator, a porphyrin, an alkylator, pyrene, a hybrid photonuclease/intercalator, or an aryl azide photo-crosslinking agent exhibit increased cellular uptake and other properties
Patent
Methods of making conjugated 4' desmethyl nucleoside analog compounds
Phillip Dan Cook,Kelly Teng +1 more
TL;DR: Tetrahydrofuranyl compounds are provided that are functionalized to include pendant conjugate groups, and which are useful in diagnostic assays and as research reagents.
Journal ArticleDOI
Copper radionuclides and radiopharmaceuticals in nuclear medicine
TL;DR: The chemistry, radiochemistry, radiobiology, and radiopharmacology of radiopharmaceuticals containing copper radionuclides are reviewed and are likely to be applied more fully in the future.
References
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Journal ArticleDOI
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
TL;DR: Using an improved method of gel electrophoresis, many hitherto unknown proteins have been found in bacteriophage T4 and some of these have been identified with specific gene products.
Journal Article
Cleavage of structural proteins during the assemble of the head of bacterio-phage T4
TL;DR: Using an improved method of gel electrophoresis, many hitherto unknown proteins have been found in bacteriophage T4 and some of these have been identified with specific gene products as mentioned in this paper.
Journal ArticleDOI
Determination of the immunoreactive fraction of radiolabeled monoclonal antibodies by linear extrapolation to binding at infinite antigen excess.
TL;DR: A binding assay for radiolabeled monoclonal antibodies in which the fraction of immunoreactive antibody is determined by linear extrapolation to conditions representing infinite antigen excess is developed.
Journal ArticleDOI
Radioactive labeling of antibody: a simple and efficient method
Donald Hnatowich,W.W. Layne,R.L. Childs,D. Lanteigne,MA Davis,Thomas W. Griffin,Paul W. Doherty +6 more
TL;DR: A simple and efficient method of covalently coupling the strong chelator diethylenetriaminepentaacetic acid to proteins was developed for radiolabeling immunoglobulin G antibodies.
Journal ArticleDOI
Conjugation of antibodies with bifunctional chelating agents: Isothiocyanate and bromoacetamide reagents, methods of analysis, and subsequent addition of metal ions☆
Claude F. Meares,Michael J. McCall,Dayton T. Reardan,David A. Goodwin,David A. Goodwin,Carol I. Diamanti,Carol I. Diamanti,Maureen McTigue,Maureen McTigue +8 more
TL;DR: The labeled products retain their immunoreactivity, as illustrated by experiments in vivo with chelate-conjugated antibody to mouse I-AK antigen.