Anticancer activity of noscapine, an opioid alkaloid in combination with cisplatin in human non-small cell lung cancer
TLDR
The results suggest that Nos enhanced the anticancer activity of Cis in an additive to synergistic manner by activating multiple signaling pathways including apoptosis and suggest potential benefit for use of Nos and Cis combination in treatment of lung cancer.About:
This article is published in Lung Cancer.The article was published on 2011-03-01 and is currently open access. It has received 113 citations till now. The article focuses on the topics: Caspase 3 & Caspase 8.read more
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Zinc oxide nanoparticles selectively induce apoptosis in human cancer cells through reactive oxygen species.
Mohd Javed Akhtar,Maqusood Ahamed,Sudhir Kumar,M.A. Majeed Khan,Javed Ahmad,Salman A. H. Alrokayan +5 more
TL;DR: It is demonstrated that ZnO NPs selectively induce apoptosis in cancer cells, which is likely to be mediated by reactive oxygen species via p53 pathway, through which most of the anticancer drugs trigger apoptosis.
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Copper oxide nanoparticles induced mitochondria mediated apoptosis in human hepatocarcinoma cells.
Maqsood A. Siddiqui,Hisham A. Alhadlaq,Javed Ahmad,Abdulaziz A. Al-Khedhairy,Javed Musarrat,Maqusood Ahamed +5 more
TL;DR: Underlying mechanism(s) of apoptosis due to CuO NPs exposure should be further invested at in vivo level and decrease in mitochondrial membrane potential with a concomitant increase in the gene expression of bax/bcl2 ratio suggested that mitochondria mediated pathway involved in CuONPs induced apoptosis.
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Oxidative stress mediated apoptosis induced by nickel ferrite nanoparticles in cultured A549 cells.
Maqusood Ahamed,Mohd Javed Akhtar,Maqsood A. Siddiqui,Javed Ahmad,Javed Musarrat,Abdulaziz A. Al-Khedhairy,Mohamad S. AlSalhi,Salman A. H. Alrokayan +7 more
TL;DR: This is the first report showing that nickel ferrite nanoparticles induced apoptosis in A549 cells through ROS generation and oxidative stress via p53, survivin, bax/bcl-2 and caspase pathways.
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Apoptosis induction by silica nanoparticles mediated through reactive oxygen species in human liver cell line HepG2
Javed Ahmad,Maqusood Ahamed,Mohd Javed Akhtar,Salman A. H. Alrokayan,Maqsood A. Siddiqui,Javed Musarrat,Abdulaziz A. Al-Khedhairy +6 more
TL;DR: It is demonstrated that silica nanoparticles induced apoptosis in human liver cells, which is ROS mediated and regulated through p53, bax/bcl-2 and caspase pathways, and co-treatment of ROS scavenger vitamin C significantly attenuated the modulation of apoptotic markers along with the preservation of cell viability caused by silica Nanoparticles.
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Skin permeating nanogel for the cutaneous co-delivery of two anti-inflammatory drugs
TL;DR: The results suggest that SP+KP-SPN have significant potential for the percutaneous delivery of SP and KP to the deeper skin layers for treatment of various skin inflammatory disorders.
References
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Mechanism of action of antitumor drugs that interact with microtubules and tubulin.
TL;DR: It can be argued that microtubules represent the single best cancer target identified to date, as considerable evidence indicates that, at lower concentrations, these drugs have a common mechanism of action; they suppress the dynamics of micro Tubulin without appreciably changing the mass of microtubule in the cell.
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The Ubiquitin-Proteasome Pathway and Proteasome Inhibitors
TL;DR: Given the importance of proteasome‐mediated protein degradation in various intracellular processes, inhibitors of this pathway will continue to serve as both molecular probes of major cellular networks as well as potential therapeutic agents for various human diseases.
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Opium alkaloid noscapine is an antitumor agent that arrests metaphase and induces apoptosis in dividing cells
Keqiang Ye,Yong Ke,Nagalakshmi Keshava,John R. Shanks,Judith A. Kapp,Rajeshwar Rao Tekmal,John A. Petros,Harish C. Joshi +7 more
TL;DR: It is shown that noscapine binds stoichiometrically to tubulin, alters its conformation, affects microtubule assembly, and arrests mammalian cells in mitosis, and causes apoptosis in many cell types.
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Bax and other pro-apoptotic Bcl-2 family "killer-proteins" and their victim the mitochondrion.
TL;DR: The structure and function of the various pro-apoptotic Bcl-2 family members, their effects on mitochondria, and their involvement in diseases are discussed.
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Role of Formulation Vehicles in Taxane Pharmacology
TL;DR: The non-ionic surfactants Cremophor EL (CrEL) and Tween 80, both used as formulation vehicles of many (anticancer) agents including paclitaxel and docetaxel, are not physiologicalinert compounds are described and their biological properties, especially the toxic side effects, and their pharmacological properties, such as modulation of P-glycoprotein activity are described.