Antimicrobial Activity of Lactoferrin-Related Peptides and Applications in Human and Veterinary Medicine.
Natascia Bruni,Maria Teresa Capucchio,Elena Biasibetti,Enrica Pessione,Simona Cirrincione,Leonardo Giraudo,Antonio Corona,Franco Dosio +7 more
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TLDR
The whey protein lactoferrin (Lf) is an iron-binding glycoprotein that plays a significant role in the innate immune system, and is considered as an important host defense molecule, which offers a new source with potential pharmaceutical applications.Citations
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Antimicrobial host defence peptides: functions and clinical potential
TL;DR: The emerging potential to therapeutically harness cationic host defence peptides to treat infectious diseases, chronic inflammatory disorders and wound healing is assessed, highlighting current preclinical studies and clinical trials.
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Milk bioactive peptide database: A comprehensive database of milk protein-derived bioactive peptides and novel visualization
TL;DR: During processing and digestion, milk proteins are disassembled into peptides with an array of biological functions, including antimicrobial, angiotensin-converting enzyme inhibition, antioxidant, opioid, and immunomodulation, which are summarized in numerous reviews.
Journal ArticleDOI
Antimicrobial Peptides: A New Hope in Biomedical and Pharmaceutical Fields
Antonio Moretta,Carmen Scieuzo,Anna Maria Petrone,Rosanna Salvia,Michele Dario Manniello,Antonio Franco,Donatella Lucchetti,Antonio Vassallo,Heiko Vogel,Alessandro Sgambato,Patrizia Falabella +10 more
TL;DR: Antimicrobial peptides (AMPs) have aroused great interest as potential next-generation antibiotics, since they are bioactive small proteins, naturally produced by all living organisms, and representing the first line of defense against fungi, viruses and bacteria as discussed by the authors.
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Bioprotective mechanisms of lactic acid bacteria against fungal spoilage of food.
TL;DR: A critical overview of the mechanisms used by LAB to inhibit spoilage organisms will be presented, and variations between the concentrations of compounds resulting from LAB activity and their inhibitory amounts are discussed.
Journal ArticleDOI
Antifungal Peptides as Therapeutic Agents.
Miguel Fernández de Ullivarri,Miguel Fernández de Ullivarri,Sara Arbulu,Sara Arbulu,Enriqueta Garcia-Gutierrez,Enriqueta Garcia-Gutierrez,Paul D. Cotter,Paul D. Cotter +7 more
TL;DR: This review provides an overview of the bioactivity and classification of AFPs (natural and synthetic), as well as their mode of action and advantages over current antifungal drugs, and evaluates the current and potential applications of these peptides.
References
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Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria?
TL;DR: In this review the different models of antimicrobial-peptide-induced pore formation and cell killing are presented and several observations suggest that translocated peptides can alter cytoplasmic membrane septum formation, inhibit cell-wall synthesis, inhibit nucleic-acid synthesis, inhibits protein synthesis or inhibit enzymatic activity.
Journal ArticleDOI
Antimicrobial and host-defense peptides as new anti-infective therapeutic strategies.
TL;DR: The role of cationic host-defense peptides in modulating the innate immune response and boosting infection-resolving immunity while dampening potentially harmful pro-inflammatory (septic) responses gives these peptides the potential to become an entirely new therapeutic approach against bacterial infections.
Journal ArticleDOI
Antibiotic resistance—the need for global solutions
Ramanan Laxminarayan,Ramanan Laxminarayan,Ramanan Laxminarayan,Adriano Duse,Chand Wattal,Anita K. M. Zaidi,Heiman F. L. Wertheim,Nithima Sumpradit,Erika Vlieghe,Gabriel Levy Hara,Ian M. Gould,Herman Goossens,Christina Greko,Anthony D. So,Maryam Bigdeli,Goeran Tomson,Will Woodhouse,Eva Ombaka,Arturo Quizhpe Peralta,Farah Naz Qamar,Fatima Mir,Sam Kariuki,Zulfigar A. Bhutta,Anthony R.M. Coates,Richard Bergstrom,Gerard D. Wright,Eric D. Brown,Otto Cars +27 more
TL;DR: The global situation of antibiotic resistance, its major causes and consequences, and key areas in which action is urgently needed are described and identified.
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Peptide Antimicrobial Agents
TL;DR: The structural requirements of peptides for antiviral and antibacterial activities are evaluated in light of the diverse set of primary and secondary structures described for host defense peptides.
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Diversity of antimicrobial peptides and their mechanisms of action.
Richard M. Epand,Hans J. Vogel +1 more
TL;DR: It is not likely that this diverse group of peptides has a single mechanism of action, but interaction of the peptides with membranes is an important requirement for most, if not all, antimicrobial peptides.
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Lactoferricin: a lactoferrin-derived peptide with antimicrobial, antiviral, antitumor and immunological properties.
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