Antioxidant, antinociceptive activity and general toxicity study of Dendrophthoe falcata and isolation of quercitrin as the major component
Shihab Hasan,Iqbal Ahmed,Sukla Mondal,Mohammad Methedi Masud,Samir Kumar Sadhu,Masami Ishibashi,Shaikh Jamal Uddin +6 more
TLDR
In this paper, the authors have evaluated the ethanolic extract of Dendrophthoe falcata leaves for their antioxidant, antinociceptive, and general toxicity.Abstract:
Plants have been used in traditional medicinal system for centuries. Bangladeshi medicinal plants have received considerable attention from the researchers for evaluation of their bioactivity. As a part of our ongoing research of screening the Bangladeshi medicinal plants, the ethanolic extract of Dendrophthoe falcata have been chosen for the present study. The ethanolic extract of the leaves of the plant have been assessed for their antioxidant, antinociceptive, and general toxicity. The extract showed potent antioxidant activity (IC50 5.1 μg/ml) using DPPH radical scavenging assay, which is comparable to the standard ascorbic acid (IC50 4.6 μg/ml). The extract significantly and dose dependently inhibited the acetic acid induced writhing in mice (71.2%, P < 0.001 and 28.0%, P < 0.05 for 500 and 250 mg/kg body weight, respectively). A general toxicity was assessed by a simple and low cost assay using brine shrimp lethality as an indicator. The extract showed low level of toxicity (LC50 100 μg/ml). Using different chromatographic techniques, quercitrin (quercetin 3-O-α-rhamnoside) was separated as the major component from the extract. The structure was elucidated by detailed 1D and 2D NMR and mass spectral analysis.read more
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TL;DR: Results provide evidence for an antioxidant mechanism underlying the anti-inflammatory activity of cat's claw and support some of the biological effects of proanthocyanidins, more exactly its antioxidant and radical scavenging activities.
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Antidiarrhoeal activity of the methanol extract of the barks of Xylocarpus moluccensis in castor oil- and magnesium sulphate-induced diarrhoea models in mice
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TL;DR: It can be assumed that Xylocarpus moluccensis could be a potential source for novel 'lead' discovery for antidiarrhoeal drug development.