Journal ArticleDOI
Antithrombin reduces ischemia/reperfusion injury of rat liver by increasing the hepatic level of prostacyclin
TLDR
It is suggested that AT may prevent I/R-induced hepatic injury by increasing the hepatic levels of PGI2 through the interaction of AT with cell-surface glycosaminoglycans, thus increasing hepatic tissue blood flow and inhibiting leukocyte activation in animals subjected to I/ R.About:
This article is published in Blood.The article was published on 1999-01-01. It has received 158 citations till now. The article focuses on the topics: Liver injury & Reperfusion injury.read more
Citations
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Journal ArticleDOI
High-Dose Antithrombin III in Severe Sepsis: A Randomized Controlled Trial
Brian Warren,Alain Eid,Pierre Singer,Subramanion S. Pillay,Peder Carl,Ivan Novak,Pavel Chalupa,Alan Atherstone,Istvan Pénzes,Andrezej Kübler,Sigurd Knaub,Heinz-Otto Keinecke,Hubert Heinrichs,Fritz Schindel,Mathias Juers,Roger C. Bone,Steven M. Opal +16 more
TL;DR: High-dose antithrombin III therapy had no effect on 28-day all-cause mortality in adult patients with severe sepsis and septic shock when administered within 6 hours after the onset and was associated with an increased risk of hemorrhage when administered with heparin.
Journal ArticleDOI
Inflammation and coagulation.
Marcel Levi,Tom van der Poll +1 more
TL;DR: It is shown that activation of the coagulation system and ensuing thrombin generation is dependent on expression of tissue factor and the simultaneous down-regulation of endothelial-bound anticoagulant mechanisms and endogenous fibrinolysis, and activated coagulations may affect specific cellular receptors on inflammatory cells and endothelial cells and thereby modulate the inflammatory response.
Journal ArticleDOI
Inflammation, endothelium, and coagulation in sepsis
TL;DR: The relationship between endothelium and coagulation in sepsis is tight and that further research is needed, for example, to better understand the role of activated PC signaling via PAR‐1, the roles of the endothelial PC receptor herein, and therole of the glycocalyx.
Journal ArticleDOI
Activated Protein C Mediates Novel Lung Endothelial Barrier Enhancement ROLE OF SPHINGOSINE 1-PHOSPHATE RECEPTOR TRANSACTIVATION
James H. Finigan,Steven M. Dudek,Patrick A. Singleton,Eddie T. Chiang,Jeffrey R. Jacobson,Sara M. Camp,Shiu Q. Ye,Joe G.N. Garcia +7 more
TL;DR: In this paper, APC was used to prevent increased EC permeability and to restore vascular integrity after edemagenic agonists after acute lung injury (ALI) through an unknown mechanism.
Journal ArticleDOI
Hepatic response to sepsis: interaction between coagulation and inflammatory processes.
TL;DR: In sepsis, the liver participates in host defense and tissue repair through hepatic cell cross-talk that controls most of the coagulation and inflammatory processes, and in turn, multiple organ failure and death.
References
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Journal ArticleDOI
Neutrophil-activating peptide-1/interleukin 8, a novel cytokine that activates neutrophils.
TL;DR: It has been shown that CSa, formylmethionyl peptides, PAF, and LTB4 act via unrelated receptors, suggesting that neutrophil recruitment can result from the concerted action of multiple stimuli.
Journal ArticleDOI
Interleukin-8, a chemotactic and inflammatory cytokine.
Marco Baggiolini,Ian Clark-Lewis +1 more
TL;DR: Five neutrophil‐activating cytokines similar to IL‐8 in structure and function have been identified recently and are thought to be the main cause of local noutrophil accumulation.
Journal ArticleDOI
The microcirculation and inflammation: modulation of leukocyte-endothelial cell adhesion
D. Neil Granger,Paul Kubes +1 more
TL;DR: The pathophysiological significance of the microvascular responses to inflammation are discussed in terms of adhesion‐directed strategies for the treatment of different cardiovascular diseases and circulatory disorders.
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Neutrophils contribute to ischemia/reperfusion injury in rat liver in vivo.
TL;DR: In this article, the role of neutrophils in the pathogenesis of hepatic ischemia/reperfusion injury was investigated in male Fischer rats, where the liver was subjected to 45 min of no-flow ischemia followed by reperfusion for up to 24 hours.