Journal ArticleDOI
Antitumor activity of the Isodon diterpenoids: structural requirements for the activity.
TLDR
The relationship between their chemical structure and antitumor activity was investigated, and the activity of oridonin and lasiokaurin was rationalized in terms of their structural feature.Abstract:
A significant antitumor activity of oridonin (1) and lasiokaurin (2), the kaurene-type diterpenoids ofIsodon species, was shown by their i.p. injection to the test mice inoculated by Ehrlich ascites carcinoma. Enmein (8), compounds9 and3 were also active under larger dose. Subsequently, the relationship between their chemical structure and antitumor activity was investigated, and the activity of oridonin (1) and lasiokaurin (2) was rationalized in terms of their structural feature.read more
Citations
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Journal ArticleDOI
Diterpenoids from Isodon species and their biological activities
TL;DR: Isodon species (Labiatae) are widely distributed plants, many of which are used in folk medicine, and have received considerable phytochemical and biological attention over the past twenty years.
Journal ArticleDOI
Oridonin, a diterpenoid extracted from medicinal herbs, targets AML1-ETO fusion protein and shows potent antitumor activity with low adverse effects on t(8;21) leukemia in vitro and in vivo
Guang-Biao Zhou,Guang-Biao Zhou,Hui Kang,Lan Wang,Li Gao,Ping Liu,Jun Xie,Feng-Xiang Zhang,Xiang-Qin Weng,Zhi-Xiang Shen,Jue Chen,Long-Jun Gu,Ming Yan,Dong-Er Zhang,Sai Juan Chen,Zhen-Yi Wang,Zhu Chen +16 more
TL;DR: The results suggest that oridonin may be a potential antileukemia agent that targets AE oncoprotein at residue D188 with low adverse effect, and may be helpful for the treatment of patients with t(8;21) AML.
Journal ArticleDOI
Plant natural compounds: targeting pathways of autophagy as anti‐cancer therapeutic agents
TL;DR: This review focuses on highlighting several representative plant natural compounds – curcumin, resveratrol, paclitaxel, oridonin, quercetin and plant lectin – that may lead to cancer cell death – for regulation of some core autophagic pathways involved in Ras‐Raf signalling, Beclin‐1 interactome, BCR‐ABL, PI3KCI/Akt/mTOR, FOXO1 signalling and p53.
Journal ArticleDOI
Oridonin: An active diterpenoid targeting cell cycle arrest, apoptotic and autophagic pathways for cancer therapeutics
TL;DR: The recent research on oridonin, an active diterpenoid with remarkable anti-proliferative activities, is demonstrated and its molecular mechanisms of cell cycle arrest, apoptosis, autophagy and their cross-talks in various cancer cells are explored, which may provide a new perspective oforidonin as a candidate anti-neoplastic drug for future cancer therapeutics.
Journal ArticleDOI
Tumor inhibitors having potential for interaction with mercapto enzymes and/or coenzymes
Eiichi Fujita,Yoshimitsu Nagao +1 more
TL;DR: As enhancement factors for the antitumor activity, the roles of hydrogen-bonding, neighboring group participation, and effect of ester side chains are introduced and may serve in the development of the new SH alkylating antitumors.
References
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Journal ArticleDOI
Recent advances in the chemistry of terpenoid tumor inhibitors
TL;DR: A continuing search for tumor inhibitors from plant sources has yielded over two hundred extracts with reproducible growth-inhibitory activity, and chemical studies of novel sesquiterpene lactones, diterpenoid quinone methides, steriod lactones and other terpenoid tumour inhibitors are discussed.
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Terpenoids. Part XV. Structure and Absolute Configuration of Oridonin isolated from Isodon japonicus and Isodon trichocarpus
TL;DR: Oridonin, a new diterpenoid from Isodon japonicus and Isodon trichocarpus, has been shown to be ent-7β,20-epoxy-1β,6α,7α,l4α-tetrahydroxy-l6-kauren-15-one (I) on the basis of chemical and spectroscopic evidence as discussed by the authors.
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Terpenoids—XI : The structure and absolute configuration of trichokaurin and its chemical conversion into (−)-kaurene and diterpene alkaloids
TL;DR: The structure and absolute configuration of trichokaurin have been established on the basis of spectral and chemical evidence as discussed by the authors, and it has been shown that the chemical transformation from trichocaurin into ent -16-oxo-17-norkauran-20-oic acid has been accomplished.
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The absolute configuration of sarkomycin.
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Terpenoids. XX. The Structure and Absolute Configuration of Lasiokaurin and Lasiodonin, New Diterpenoids from Isodon lasiocarpus (HAYATA) KUDO
Eiichi Fujita,Manabu Taoka +1 more
TL;DR: In this article, the structure and absolute configuration of lasiokaurin and lasiodonin, which were isolated from Isodon lasiocarpus (HAYATA) KUDO, were established as ent-7β, 20-epoxy-1β-acetoxy-15-oxo-16-kaurene-6α, 7α, 14α-triol (II) and ent