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Aromatase inhibitors from Broussonetia papyrifera
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In this article, a composition and method of cancer treatment using B. papyrifera extract and compounds having aromatase inhibition properties was presented. But the method was not described.Abstract:
A composition and method of cancer treatment is disclosed. The composition and method utilize the extract of B. papyrifera, or compounds included therein having aromatase inhibition properties, as active cancer chemopreventative and treating agents in mammals, including humans.read more
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Drug discovery from medicinal plants.
TL;DR: Several compounds from tropical rainforest plant species with potential anticancer activity have been identified and several compounds, mainly from edible plant species or plants used as dietary supplements, that may act as chemopreventive agents are isolated.
Journal ArticleDOI
Chalcone: A Privileged Structure in Medicinal Chemistry.
TL;DR: This review aims to highlight the recent evidence of chalcone as a privileged scaffold in medicinal chemistry and is expected to be a comprehensive, authoritative, and critical review of the chal cone template to the chemistry community.
Journal ArticleDOI
Botanicals in Cancer Chemoprevention
Eun Jung Park,John M. Pezzuto +1 more
TL;DR: Several lead compounds, such as brassinin (from cruciferous vegetables like Chinese cabbage), sulforaphane (from broccoli) and its analog sulforamate, withanolides (from tomatillos), and resveratrol (from grapes and peanuts) are in preclinical or clinical trials for cancer chemoprevention.
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Interference of endocrine disrupting chemicals with aromatase CYP19 expression or activity, and consequences for reproduction of teleost fish.
TL;DR: Diverse EDCs may affect the expression and/or activity of aromatase cyp19 genes through a variety of mechanisms, many of which need further characterization in order to improve the prediction of risks posed by a contaminated environment to teleost fish population.
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Naturally occurring chalcones and their biological activities
Zsuzsanna Rozmer,Pál Perjési +1 more
TL;DR: The aim of this review is to summarize the various naturally occurring chalcone compounds which have been isolated from different plants to initiate further pharmacobotanical, biotechnological and medicinal studies on the field of chal cone research.
References
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Circular dichroism, optical rotatory dispersion and absolute configuration of flavanones, 3-hydroxyflavanones and their glycosides : Determination of aglycone chirality in flavanone glycosides☆
TL;DR: In this paper, the 2 S configuration and 3-hydroxy-flavanones of 2 R, 3 R configuration, having equatorial 2-aryl substituents in the former or diequatorial 2,3-substituents of the latter, exhibit a positive Cotton effect due to the n → π * transition (∼ 330 nm) and a negative Cotton effect in the n α π ∆ * region(∼ 280-290 nm).
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Molecular basis of the inhibition of human aromatase (estrogen synthetase) by flavone and isoflavone phytoestrogens: A site-directed mutagenesis study.
TL;DR: The binding characteristics and the structure requirement for flavone and isoflavone phytoestrogens to inhibit human aromatase were obtained and these compounds were found to bind to the active site of aromat enzyme in an orientation in which rings A and C mimic rings D and C of the androgen substrate, respectively.
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Inhibition of human estrogen synthetase (aromatase) by flavones
James T. Kellis,Larry E. Vickery +1 more
TL;DR: Several naturally occurring and synthetic flavones were found to inhibit the aromatization of androstenedione and testosterone to estrogens catalyzed by human placental and ovarian microsomes and compete with steroids in their interaction with certain monooxygenases and thereby alter steroid hormone metabolism.
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Inhibition of proliferation of estrogen receptor-positive MCF-7 human breast cancer cells by flavonoids in the presence and absence of excess estrogen
TL;DR: Of the flavonoids tested, only the inhibition of cell proliferation by genistein was reversed with the addition of excess, competing estrogen, and Baicalein, galangin, hesperetin, naringenin and quercetin apparently exert their antiproliferative activity via some other mechanism.
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Flavonoids suppress androgen-independent human prostate tumor proliferation
TL;DR: It is suggested that alterations in cell cycle progression contribute significantly to the antiproliferative effects of quercetin and kaempferol in PC-3 cells.