Journal ArticleDOI
Inhibition of human estrogen synthetase (aromatase) by flavones
James T. Kellis,Larry E. Vickery +1 more
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Several naturally occurring and synthetic flavones were found to inhibit the aromatization of androstenedione and testosterone to estrogens catalyzed by human placental and ovarian microsomes and compete with steroids in their interaction with certain monooxygenases and thereby alter steroid hormone metabolism.Abstract:
Several naturally occurring and synthetic flavones were found to inhibit the aromatization of androstenedione and testosterone to estrogens catalyzed by human placental and ovarian microsomes. These flavones include (in order of decreasing potency) 7,8-benzoflavone, chrysin, apigenin, flavone, flavanone, and quercetin; 5,6-benzoflavone was not inhibitory. 7,8-Benzoflavone and chrysin were potent competitive inhibitors and induced spectral changes in the aromatase cytochrome P-450 indicative of substrate displacement. Flavones may thus compete with steroids in their interaction with certain monooxygenases and thereby alter steroid hormone metabolism.read more
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Journal Article
The Effects of Plant Flavonoids on Mammalian Cells:Implications for Inflammation, Heart Disease, and Cancer
TL;DR: Western medicine has not yet used flavonoids therapeutically, even though their safety record is exceptional, and suggestions are made where such possibilities may be worth pursuing.
Journal ArticleDOI
DIETARY FLAVONOIDS: Bioavailability, Metabolic Effects, and Safety
Julie A. Ross,Christine M. Kasum +1 more
TL;DR: Investigation in the possible health benefits of flavonoids has increased owing to their potent antioxidant and free-radical scavenging activities observed in vitro, and there is growing evidence from human feeding studies that the absorption and bioavailability of specific flavonoid is much higher than originally believed.
Journal ArticleDOI
Phyto-oestrogens and Western Diseases
Herman Adlercreutz,Witold Mazur +1 more
TL;DR: Evidence is provided suggesting that both lignans and isoflavonoids may prevent the development of cancer as well as atherosclerosis, and no definite recommendations can be made as to the dietary amounts needed for prevention of disease.
Journal ArticleDOI
Phytoestrogens: the biochemistry, physiology, and implications for human health of soy isoflavones.
TL;DR: The importance of a plant-based diet is evident from the current dietary recommendations that emphasize an increase in the proportion and amount of fruit and vegetables that should be consumed, and interpretation of the role of individual components of the diet is difficult from epidemiologic and dietary studies.
Journal ArticleDOI
Dietary flavonoids: effects on xenobiotic and carcinogen metabolism.
TL;DR: The cancer protective effects of flavonoids have been attributed to a wide variety of mechanisms, including modulating enzyme activities resulting in the decreased carcinogenicity of xenobiotics and phase II enzymes, largely responsible for the detoxification of carcinogens.
References
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Book ChapterDOI
The flavonoids. A class of semi-essential food components: their role in human nutrition.
TL;DR: A review of the chemistry, the fate of food flavonoids, and their nutritional effects can be found in this paper, where the authors discuss the antibiotic and/or bacteriostatic effects of foods rich in these compounds.
Journal ArticleDOI
Flavonols and flavones in food plants: a review†
TL;DR: The qualitative and quantitative occurrence of flavonols and flavones, particularly in fruit and vegetables, are considered in this paper, where the authors present a review of the qualitative, quantitative and qualitative occurrence of these compounds.
Journal ArticleDOI
The Involvement of Human Placental Microsomal Cytochrome P-450 in Aromatization
Thompson Ea,Siiteri Pk +1 more
TL;DR: It was determined that steroid binding to placental microsomal cytochrome P-450 is absolutely specific for aromatase substrates, intermediates, and inhibitors, and suggest that a single species of cyto chrome P- 450 is responsible for the aromatization of both steroids.
Journal ArticleDOI
Potential Value of Plants as Sources of New Antifertility Agents II
TL;DR: The preovulatory, preimplantation, and postIMplantation antifertility mechanisms of plant substances affecting the hypothalamus-pituitary, ovary, oviduct, uterus, or vagina are discussed in terms of reproductive differences among laboratory animal species.