Artocarpus plants as a potential source of skin whitening agents.
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TLDR
In the in vivo investigation, the extract of the wood of Artocarpus incisus and a representative isolated compound from it, artocarpin had a lightening effect on the skin of guinea pigs’ backs, indicating that the extracts of ArtOCarpus plants are potential sources for skin whitening agents.Abstract:
Artocarpus plants have been a focus of constant attention due to the potential for skin whitening agents. In the in vitro experiment, compounds from the Artocarpus plants, such as artocarpanone, no...read more
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4-n-butylresorcinol, a highly effective tyrosinase inhibitor for the topical treatment of hyperpigmentation.
Ludger Kolbe,Tobias Mann,Wolfram Gerwat,Jan Batzer,Sabrina Ahlheit,Cathrin Scherner,Horst Wenck,Franz Stäb +7 more
TL;DR: This paper focuses on the treatment of hyperpigmentary disorders like melasma, actinic and senile lentigines with inhibitors of tyrosinase, the key regulator of melanin production.
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Artocarpus lakoocha Roxb. and Artocarpus heterophyllus Lam. Flowers: New Sources of Bioactive Compounds.
Arun Kumar Gupta,Muzamil Ahmad Rather,Avinash Kumar Jha,Abhinay Shashank,Somya Singhal,Maanas Sharma,Urbi Pathak,Dipti Sharma,Andrea Mastinu +8 more
TL;DR: The ability of AH and AL extracts to modulate the gene expression of some targets involved in the antioxidant response was studied and the results obtained highlighted the nutritional and antioxidant value of theAH and AL flower extracts.
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Cudraflavone C induces tumor-specific apoptosis in colorectal cancer cells through inhibition of the phosphoinositide 3-kinase (PI3K)-AKT pathway
Hsien-Chuen Soo,Felicia Fei-Lei Chung,Kuan-Hon Lim,Veronica Alicia Yap,Tracey D. Bradshaw,Ling-Wei Hii,Si-Hoey Tan,Sze-Jia See,Yuen-Fen Tan,Chee-Onn Leong,Chun-Wai Mai +10 more
TL;DR: Investigation of the effects of Cud C on cell proliferation, caspase activation andapoptosis induction in colorectal cancer cells (CRC) shows that it induces tumor-selective cytotoxicity by targeting the PI3K-AKT pathway, and provides novel insights into the mechanism of action.
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Cudraflavone C Induces Apoptosis of A375.S2 Melanoma Cells through Mitochondrial ROS Production and MAPK Activation.
Chiang-Wen Lee,Feng-Lin Yen,Horng-Huey Ko,Shu-Yu Li,Yao-Chang Chiang,Yao-Chang Chiang,Ming-Hsueh Lee,Ming-Horng Tsai,Lee-Fen Hsu +8 more
TL;DR: It was observed that cudraflavone C inhibited growth in A375.S2 melanoma cells, and promoted apoptosis via the mitochondrial pathway mediated by increased mitochondrial ROS production, which may be regarded as a potential form of treatment for malignant melanoma.
Journal Article
A review on skin whitening property of plant extracts
TL;DR: A number of potent tyrosinase inhibitors are from synthetic, semi-synthetic and natural origins are discussed in this article, where diverse medicinal plants extract with potent skin whitening property are discussed.
References
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Cyclic AMP a Key Messenger in the Regulation of Skin Pigmentation
Roser Buscà,Robert Ballotti +1 more
TL;DR: It appears that melanogenic gene expression is controlled by a complex network of regulation involving other transcription factors such as Brn2, TBX2, PAX3 and SOX10, which would finally allow a fine tuning of melanocyte differentiation leading to melanin synthesis.
Journal ArticleDOI
Kojic Acid, a Cosmetic Skin Whitening Agent, is a Slow-binding Inhibitor of Catecholase Activity of Tyrosinase
TL;DR: It was found that kojic acid, which is used in cosmetics for its excellent whitening effect, inhibits catecholase activity of tyrosinase in a non‐classical manner.
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TL;DR: Molecules, such as xanthohumol and sophoraflavanone G, while being very structurally simple, show numerous pharmacological applications and are ideal candidates for SAR aimed to the discovery of new drugs.
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Artocarpus: A review of its traditional uses, phytochemistry and pharmacology
Umesh B. Jagtap,Vishwas A. Bapat +1 more
TL;DR: In the present review, attempts on the important findings have been made on identification; synthesis and bioactivity of metabolites present in Artocarpus which have been highlighted along with the current trends in research on Artoc carpus.