Journal ArticleDOI
Assessment of DNA damage by extracts and fractions of Strychnos pseudoquina, a Brazilian medicinal plant with antiulcerogenic activity
Fabio V. Santos,Ilce Mara de Syllos Cólus,M. A. Silva,Wagner Vilegas,Eliana Aparecida Varanda +4 more
TLDR
The genotoxic potential of crude extracts and fractions containing alkaloids and flavonoids from the leaves of this plant, on Salmonella typhimurium and the micronucleus test on peripheral blood cells of mice treated in vivo showed that the methanol extract of the Leaves of S. pseudoquina is mutagenic to the TA98 (-S9) and TA100 (+S9, -S9).About:
This article is published in Food and Chemical Toxicology.The article was published on 2006-09-01. It has received 75 citations till now.read more
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Micronuclei in genotoxicity assessment: from genetics to epigenetics and beyond.
TL;DR: The genetic and epigenetic mechanisms of MN formation after various clastogenic and aneugenic effects on cell division and cell cycle are described and individual sensitivity to MN formation due to single gene polymorphisms is discussed.
Journal ArticleDOI
Ethnopharmacology of Medicinal Plants of the Pantanal Region (Mato Grosso, Brazil)
Isanete Geraldini Costa Bieski,Fabrício Rios Santos,Rafael Melo de Oliveira,Mariano Martinez Espinosa,Miramy Macedo,Ulysses Paulino Albuquerque,Domingos Tabajara de Oliveira Martins +6 more
TL;DR: The results show that knowledge about medicinal plants is evenly distributed among the population of NSACD, which possesses medicinal plants for most disease categories, with the highest concordance for prenatal, mental/behavioral and respiratory problems.
Journal ArticleDOI
Mutagenicity of flavonoids assayed by bacterial reverse mutation (Ames) test.
Flávia Aparecida Resende,Wagner Vilegas,Lourdes Campaner dos Santos,Eliana Aparecida Varanda +3 more
TL;DR: It is necessary to clarify the conditions and the mechanisms that mediate the biological effects of flavonoids before treating them as therapeutical agents, since some compounds can be biotransformed into more genotoxic products; as is the case for galangin, kaempferol and quercetin.
Journal ArticleDOI
Plants of restricted use indicated by three cultures in Brazil (Caboclo-river dweller, Indian and Quilombola)
TL;DR: This study describes 57 plant species of restricted use as indicated during ethnopharmacological surveys carried out among three cultures in Brazil, finding 5 out of the 57 species have some toxic properties described up to the present time.
Journal ArticleDOI
Does the gastroprotective action of a medicinal plant ensure healing effects? An integrative study of the biological effects of Serjania marginata Casar. (Sapindaceae) in rats.
Larissa Lucena Périco,Silvia Cristina Heredia-Vieira,Fernando Pereira Beserra,Raquel de Cássia dos Santos,Marcio Barczyszyn Weiss,Flávia Aparecida Resende,Matheus Aparecido dos Santos Ramos,Bruna Vidal Bonifácio,Taís Maria Bauab,Eliana Aparecida Varanda,Juliana Irani Fratucci De Gobbi,Lucia Regina Machado da Rocha,Wagner Vilegas,Clélia Akiko Hiruma-Lima +13 more
TL;DR: Despite the anti-H.
References
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Journal ArticleDOI
Revised methods for the salmonella mutagenicity test
Dorothy M. Maron,Bruce N. Ames +1 more
TL;DR: Two new tester strains, a frameshift strain and a strain carrying an ochre mutation on a multicopy plasmid (TA102), are added to the standard tester set and two substitutions are made in diagnostic mutagens to eliminate MNNG and 9-aminoacridine.
Journal ArticleDOI
The Ames Salmonella/microsome mutagenicity assay
Kristien Mortelmans,Errol Zeiger +1 more
TL;DR: Historical aspects of how the Ames test was developed and detailed procedures for performing the test, including the design and interpretation of results are provided, to determine the mutagenic potential of new chemicals and drugs.
Journal ArticleDOI
13C NMR spectra of pentacyclic triterpenoids--a compilation and some salient features
Shashi B. Mahato,Asish P. Kundu +1 more
TL;DR: In this paper, a compilation of the 13C NMR data of a selected variety of naturally occurring pentacyclic triterpenoids, arranged skeletonwise, is provided.
Journal Article
Carbon-13 NMR of flavonoids
TL;DR: Agrawal et al. as mentioned in this paper proposed a method for signal assignment of carbon-13 NMR spectroscopy images of the flavonoid structures and established the aromatic substitution pattern.