Association between exposure to ambient particulate matter and chronic obstructive pulmonary disease: results from a cross-sectional study in China
Sha Liu,Yumin Zhou,Suixin Liu,Xinyu Chen,Weifeng Zou,Dongxing Zhao,Xiaochen Li,Jinding Pu,Lingmei Huang,Jinlong Chen,Bing Li,Shiliang Liu,Shiliang Liu,Pixin Ran +13 more
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TLDR
Exposure to higher PM concentrations was strongly associated with increased COPD prevalence and declined respiratory function and the associations of COPD with PM10 were consistent with PM2.5 but slightly weaker.Abstract:
Objective The association between exposure to ambient particles with a median aerodynamic diameter less than 10/2.5 µm (particulate matter, PM 10 / 2.5 ) and COPD remains unclear. Our study objective was to examine the association between ambient PM 10 / 2.5 concentrations and lung functions in adults. Methods A cross-sectional study was conducted in southern China. Seven clusters were randomly selected from four cities across Guangdong province. Residents aged ≥20 years in the participating clusters were randomly recruited; all eligible participants were examined with a standardised questionnaire and spirometry. COPD was defined as a post-bronchodilator FEV 1 /FVC less than 70%. Atmosphere PM sampling was conducted across the clusters along with our survey. Results Of the subjects initially recruited, 84.4% (n=5993) were included for analysis. COPD prevalence and atmosphere PM concentration varied significantly among the seven clusters. COPD prevalence was significantly associated with elevated PM concentration levels: adjusted OR 2.416 (95% CI 1.417 to 4.118) for >35 and ≤75 µg/m 3 and 2.530 (1.280 to 5.001) for >75 µg/m 3 compared with the level of ≤35 µg/m 3 for PM 2.5 ; adjusted OR 2.442 (95% CI 1.449 to 4.117) for >50 and ≤150 µg/m 3 compared with the level of ≤50 µg/m 3 for PM 1 . A 10 µg/m 3 increase in PM 2.5 concentrations was associated with a 26 mL (95% CI −43 to −9) decrease in FEV 1 , a 28 mL (−49 to −8) decrease in FVC and a 0.09% decrease (−0.170 to −0.010) in FEV 1 /FVC ratio. The associations of COPD with PM 10 were consistent with PM 2.5 but slightly weaker. Conclusions Exposure to higher PM concentrations was strongly associated with increased COPD prevalence and declined respiratory function. Trial registration number ChiCTR-OO-14004264; Post-results.read more
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Prevalence and risk factors of chronic obstructive pulmonary disease in China (the China Pulmonary Health [CPH] study): a national cross-sectional study.
Chen Wang,Jianying Xu,Lan Yang,Yong-jian Xu,Xiangyan Zhang,Chunxue Bai,Jian Kang,Pixin Ran,Huahao Shen,Fuqiang Wen,Kewu Huang,Wanzhen Yao,Tie-ying Sun,Guangliang Shan,Ting Yang,Ting Yang,Yingxiang Lin,Sinan Wu,Jianguo Zhu,Ruiying Wang,Zhihong Shi,Jianping Zhao,Xianwei Ye,Yuanlin Song,Qiuyue Wang,Yumin Zhou,Liren Ding,Yahong Chen,Yanfei Guo,Fei Xiao,Yong Lu,Xiaoxia Peng,Biao Zhang,Dan Xiao,Chung-Shiuan Chen,Zuomin Wang,Hong Zhang,Xiaoning Bu,Xiaolei Zhang,Xiaolei Zhang,Li An,Shu Zhang,Zhixin Cao,Qingyuan Zhan,Qingyuan Zhan,Yuanhua Yang,Bin Cao,Bin Cao,Huaping Dai,Huaping Dai,Lirong Liang,Jiang He +51 more
TL;DR: Prevalence of spirometry-defined COPD is highly prevalent in the Chinese adult population and prevention and early detection of COPD using spirometry should be a public health priority in China to reduce COPD-related morbidity and mortality.
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Urban particulate matter triggers lung inflammation via the ROS-MAPK-NF-κB signaling pathway.
Jian Wang,Jianan Huang,Linlin Wang,Cuicui Chen,Dong Yang,Meiling Jin,Chunxue Bai,Yuanlin Song +7 more
TL;DR: PM exposure enhanced the airway inflammatory response significantly through ROS-mediated activation of MAPK (ERK, JNK, p38 MAPK) and downstream NF-κB signaling pathways and appeared to be the key regulator for PM-induced lung inflammation.
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Air pollution associated epigenetic modifications: Transgenerational inheritance and underlying molecular mechanisms
Anushi Shukla,Neha Bunkar,Rajat Kumar,Arpit Bhargava,Rajnarayan R Tiwari,Koel Chaudhury,Irina Yu. Goryacheva,Pradyumna Kumar Mishra +7 more
TL;DR: The recent literature supports the contention that air pollution might contribute to transmission of epimutations from gametes to zygotes by involving mitochondrial DNA, parental allele imprinting, histone withholding and non-coding RNAs, and larger prospective studies using innovative, integrated epigenome-wide metabolomic strategy are highly warranted.
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Gut microbiota dysbiosis contributes to the development of chronic obstructive pulmonary disease.
Naijian Li,Zhouli Dai,Zhang Wang,Zhishan Deng,Jiahuan Zhang,Jinding Pu,Weitao Cao,Tianhui Pan,Yumin Zhou,Zhaowei Yang,Jing Li,Bing Li,Pixin Ran +12 more
TL;DR: It is demonstrated that altered gut microbiota in COPD patients is associated with disease progression in mice model and was characterized by a distinct overall microbial diversity and composition, a Prevotella-dominated gut enterotype and lower levels of short-chain fatty acids.
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TL;DR: None of the principal results were statistically significant, the weak positive associations of exposure with COPD and the significant subgroup findings need to be evaluated in further well standardised cohorts followed up for longer time, and with time-matched exposure assignments.
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