Journal ArticleDOI
Association between obesity and a prothrombotic state: the Framingham Offspring Study
Guido A. Rosito,Ralph B. D'Agostino,Joseph M. Massaro,Izabella Lipinska,Murray A. Mittleman,Patrice Sutherland,Peter W.F. Wilson,Daniel Levy,James E. Muller,Geoffrey H. Tofler +9 more
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TLDR
The association between increased body mass index and waist-to-hip ratio and prothrombotic factors and impaired fibrinolysis suggests that obesity is a risk factor whose effect is mediated in part by a prothromabotic state.Abstract:
Although obesity is associated with increased cardiovascular risk, the mechanism has not been fully explained. Since thrombosis is a critical component of cardiovascular disease, we examined the relationship between obesity and hemostatic factors. We studied 3230 subjects (55% females, mean age 54 years) without a history of cardiovascular disease in cycle 5 of the Framingham Offspring Study. Obesity was assessed by body mass index and waist-to-hip ratio. Fasting blood samples were obtained for fibrinogen, plasminogen activator inhibitor (PAI-1) antigen, tissue plasminogen activator (tPA) antigen, factor VII antigen, von Willebrand factor (VWF), and plasma viscosity. Body mass index was directly associated with fibrinogen, factor VII, PAI-1 and tPA antigen in both men and women (pread more
Citations
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Guidelines for the Prevention of Stroke in Women A Statement for Healthcare Professionals From the American Heart Association/American Stroke Association
Cheryl Bushnell,Louise D. McCullough,Issam A. Awad,Monique V. Chireau,Wende N. Fedder,Karen L. Furie,Virginia J. Howard,Judith H. Lichtman,Lynda D. Lisabeth,Ileana L. Piña,Mathew J. Reeves,Kathryn M. Rexrode,Gustavo Saposnik,Vineeta Singh,Amytis Towfighi,Viola Vaccarino,Matthew Walters +16 more
TL;DR: This guideline focuses on the risk factors unique to women, such as reproductive factors, and those that are more common in women, including migraine with aura, obesity, metabolic syndrome, and atrial fibrillation, which believe a female-specific stroke risk score is warranted.
Journal ArticleDOI
Determinants and Time Course of the Postthrombotic Syndrome after Acute Deep Venous Thrombosis
Susan R. Kahn,Ian Shrier,Jim A. Julian,Thierry Ducruet,Louise Arsenault,Marie-José Miron,Andre Roussin,Sylvie Desmarais,Jeannine Kassis,Susan Solymoss,Louis Desjardins,Donna L. Lamping,Mira Johri,Jeffrey S. Ginsberg +13 more
TL;DR: The postthrombotic syndrome occurs frequently after acute venous thrombosis, and patients with extensive DVT and those with more severe postthROMbotic manifestations 1 month after DVT have poorer long-term outcomes.
Journal ArticleDOI
Different contributions of polymorphisms in VKORC1 and CYP2C9 to intra- and inter-population differences in maintenance dose of warfarin in Japanese, Caucasians and African-Americans
Harumi Takahashi,Grant R. Wilkinson,Edith A. Nutescu,Takashi Morita,Marylyn D. Ritchie,Maria Gabriella Scordo,Vittorio Pengo,Martina Barban,Roberto Padrini,Ichiro Ieiri,Kenji Otsubo,Toshitaka Kashima,Sosuke Kimura,Shinichi Kijima,Hirotoshi Echizen +14 more
TL;DR: Japanese are more susceptible to inhibition of NPT production by S-warfarin than the other two populations, and VKORC1 and CYP2C9 polymorphisms contribute to inter-population difference in warfarin doses among the three populations, but their contribution to intra-population variability may differ within each population.
Journal ArticleDOI
Future Cardiovascular Disease in China Markov Model and Risk Factor Scenario Projections From the Coronary Heart Disease Policy Model–China
Andrew E. Moran,Dongfeng Gu,Dong Zhao,Pamela G. Coxson,Y. Claire Wang,Chung-Shiuan Chen,Jing Liu,Jun Cheng,Kirsten Bibbins-Domingo,Yu-Ming Shen,Jiang He,Lee Goldman +11 more
TL;DR: Aging and population growth will increase cardiovascular disease by more than a half over the coming 20 years, and projected unfavorable trends in blood pressure, total cholesterol, diabetes, and body mass index may accelerate the epidemic.
Journal ArticleDOI
Risk of venous thrombosis: obesity and its joint effect with oral contraceptive use and prothrombotic mutations.
TL;DR: Body height, weight and obesity increase the risk of venous thrombosis, especially obesity in women using oral contraceptives, and the joint effect of obesity together with oral contraceptive use and prothrombotic mutations was analysed.
References
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Journal ArticleDOI
Haemostatic function and ischaemic heart disease: principal results of the northwick park heart study
T.W. Meade,Milica Brozovic,R. Chakrabarti,Andy Haines,J D Imeson,Sandra Mellows,G.J. Miller,W R S North,Yvonne Stirling,S.G. Thompson +9 more
TL;DR: The Northwick Park Heart Study has investigated the thrombotic component of ischaemic heart disease by the inclusion of measures of haemostatic function, finding that the biochemical disturbance leading to IHD may lie at least as much in the coagulation system as in the metabolism of cholesterol.
Journal ArticleDOI
An investigation of coronary heart disease in families the framingham offspring study
William B. Kannel,Manning Feinleib,Patricia M. McNamara,Robert J. Garrison,William P. Castelli +4 more
TL;DR: There is little evidence that coronary heart disease (CHD) experience and CHD risk factors differ in parents of those who volunteered for this study and the parents ofThose who did not volunteer.
Journal ArticleDOI
Increased plasma levels of a rapid inhibitor of tissue plasminogen activator in young survivors of myocardial infarction
TL;DR: Reduced fibrinolytic capacity due to increased plasma levels of a rapid inhibitor of t-PA may have pathogenetic importance in myocardial infarction, particularly in patients with hypertriglyceridemia.
Journal ArticleDOI
Medical Hazards of Obesity
TL;DR: Obesity is an independent risk factor for death from coronary heart disease and some forms of cancer as well as sleep apnea, chronic hypoxia and hypercapnia, and degenerative joint disease.
Journal ArticleDOI
AHA/ACC Guidelines for Preventing Heart Attack and Death in Patients With Atherosclerotic Cardiovascular Disease: 2001 Update A Statement for Healthcare Professionals From the American Heart Association and the American College of Cardiology
Sidney C. Smith,Steven N. Blair,Robert O. Bonow,Lawrence M. Brass,Manuel D. Cerqueira,Kathleen Dracup,Valentin Fuster,Antonio M. Gotto,Scott M. Grundy,Nancy Houston Miller,Alice K. Jacobs,Daniel Jones,Ronald M. Krauss,Lori Mosca,Ira S. Ockene,Richard C. Pasternak,Thomas A. Pearson,Marc A. Pfeffer,Rodman D. Starke,Kathryn A. Taubert +19 more
TL;DR: Since the original publication (in 1995) of the AHA consensus statement on secondary prevention, important evidence from clinical trials has emerged that further supports the merits of aggressive risk reduction therapies for patients with atherosclerotic cardiovascular disease.
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