U
U de Faire
Researcher at Karolinska Institutet
Publications - 157
Citations - 17769
U de Faire is an academic researcher from Karolinska Institutet. The author has contributed to research in topics: Population & Myocardial infarction. The author has an hindex of 58, co-authored 157 publications receiving 16679 citations. Previous affiliations of U de Faire include Memorial Hospital of South Bend & Children's Hospital Oakland Research Institute.
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Journal ArticleDOI
Increased plasma levels of a rapid inhibitor of tissue plasminogen activator in young survivors of myocardial infarction
TL;DR: Reduced fibrinolytic capacity due to increased plasma levels of a rapid inhibitor of t-PA may have pathogenetic importance in myocardial infarction, particularly in patients with hypertriglyceridemia.
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Genetic Susceptibility to Death from Coronary Heart Disease in a Study of Twins
TL;DR: The findings suggest that at younger ages, death from coronary heart disease is influenced by genetic factors in both women and men, and implies that the genetic effect decreases at older ages.
Journal ArticleDOI
Genetic Variants Associated with Lp(a) Lipoprotein Level and Coronary Disease
Robert Clarke,John F. Peden,J C Hopewell,Theodosios Kyriakou,Anuj Goel,Simon Heath,Sarah Parish,Simona Barlera,MariaGrazia Franzosi,Stephan Rust,Derrick A Bennett,Angela Silveira,Anders Mälarstig,Fiona R. Green,M Lathrop,Bruna Gigante,Karin Leander,U de Faire,Udo Seedorf,Anders Hamsten,Rory Collins,Hugh Watkins,Martin Farrall +22 more
TL;DR: Two LPA variants were strongly associated with both an increased level of Lp(a) lipoprotein and an increased risk of coronary disease, and the association between the LPA genotype score and the risk of heart disease was abolished.
Journal ArticleDOI
The interleukin-6 receptor as a target for prevention of coronary heart disease: a mendelian randomisation analysis.
Daniel I. Swerdlow,Michael V. Holmes,Karoline Kuchenbaecker,Engmann Jel.,Tina Shah,Reecha Sofat,Yiran Guo,C Chung,Anne Peasey,Roman Pfister,Simon P. Mooijaart,Helen Ireland,Maarten Leusink,Claudia Langenberg,KaWah Li,Jutta Palmen,Phil Howard,Jackie A. Cooper,Fotios Drenos,John Hardy,Mike A. Nalls,Yun Li,Gordon D.O. Lowe,Marlene C. W. Stewart,S. J. Bielinski,Julian Peto,Nicholas J. Timpson,John Gallacher,Malcolm G. Dunlop,Richard S. Houlston,Ian Tomlinson,Ioanna Tzoulaki,Jian'an Luan,Boer Jma.,Nita G. Forouhi,N. C. Onland-Moret,Y. T. van der Schouw,Renate B. Schnabel,Jaroslav A. Hubacek,Růžena Kubínová,Migle Baceviciene,Abdonas Tamosiunas,Andrzej Pajak,Roman Topor-Madry,Sofia Malyutina,Damiano Baldassarre,Bengt Sennblad,Elena Tremoli,U de Faire,Luigi Ferrucci,S Bandenelli,Tetsu Tanaka,James F. Meschia,AB Singleton,Gerjan Navis,I. Mateo Leach,Bakker Sjl.,Ron T. Gansevoort,Ian Ford,Stephen E. Epstein,Mary-Susan Burnett,Joe Devaney,Johan Wouter Jukema,Westendorp Rgj.,G Jan de Borst,Y. van der Graaf,P A de Jong,Mailand-van der Zee A-H.,Olaf H. Klungel,A. de Boer,P. A. Doevendans,Jeffrey W. Stephens,Charles B. Eaton,Jennifer G. Robinson,JoAnn E. Manson,F G Fowkes,Timothy M. Frayling,Jenna Price,Peter H. Whincup,Richard W Morris,Debbie A Lawlor,George Davey Smith,Yoav Ben-Shlomo,Susan Redline,Leslie A. Lange,Meena Kumari,Nicholas J. Wareham,Verschuren Wmm.,Emelia J. Benjamin,John C. Whittaker,Anders Hamsten,Frank Dudbridge,Delaney Jac.,Andrew Wong,Diana Kuh,Rebecca Hardy,Berta Almoguera Castillo,John Connolly,P. van der Harst,Eric J. Brunner,Michael Marmot,Christina L. Wassel,Steve E. Humphries,P.J. Talmud,Mika Kivimäki,Folkert W. Asselbergs,Mikhail I. Voevoda,Martin Bobak,Hynek Pikhart,James G. Wilson,Hakon Hakonarson,Alexander P. Reiner,Brendan J. Keating,Naveed Sattar,Aroon D. Hingorani,Juan P. Casas +115 more
TL;DR: IL6R blockade could provide a novel therapeutic approach to prevention of coronary heart disease that warrants testing in suitably powered randomised trials and could help to validate and prioritise novel drug targets or to repurpose existing agents and targets for new therapeutic uses.
Journal ArticleDOI
The Swedish Twin Registry: a unique resource for clinical, epidemiological and genetic studies.
Paul Lichtenstein,U de Faire,Birgitta Floderus,Magnus Svartengren,Pia Svedberg,Nancy L. Pedersen,Nancy L. Pedersen +6 more
TL;DR: The Swedish Twin Registry is a unique resource for clinical, epidemiological and genetic studies (Review) and should be considered for further study.