Journal ArticleDOI
Attraction between negatively charged surfaces mediated by spherical counterions with quadrupolar charge distribution
Jasna Urbanija,Klemen Bohinc,Alfredo Bellen,Stefano Maset,Aleš Iglič,Veronika Kralj-Iglič,P. B. Sunil Kumar +6 more
TLDR
For high enough charge densities of the interacting surfaces and large enough l, the interaction between surfaces turns repulsive as the distance between charges is reduced, and within a mean field approach an attractive interaction between like-charged surfaces originating from orientational ordering of quadrupolar counterions is obtained.Abstract:
We observed monoclonal antibody mediated coalescence of negatively charged giant unilamellar phospholipid vesicles upon close approach of the vesicles. This feature is described, using a mean field density functional theory and Monte Carlo simulations, as that of two interacting flat electrical double layers. Antibodies are considered as spherical counterions of finite dimensions with two equal effective charges spatially separated by a fixed distance l inside it. We calculate the equilibrium configuration of the system by minimizing the free energy. The results obtained by solving the integrodifferential equation and by performing the Monte Carlo simulation are in excellent agreement. For high enough charge densities of the interacting surfaces and large enough l, we obtain within a mean field approach an attractive interaction between like-charged surfaces originating from orientational ordering of quadrupolar counterions. As expected, the interaction between surfaces turns repulsive as the distance between charges is reduced.read more
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Effects of low-molecular-weight heparin on adhesion and vesiculation of phospholipid membranes: a possible mechanism for the treatment of hypercoagulability in antiphospholipid syndrome.
TL;DR: A novel anticoagulant mechanism of nadroparin in APS is suggested that supplements its direct effect on the coagulation cascade and might decrease shedding of microvesicles into the surrounding solution and could thus contribute to the efficacy of heparin treatment in APs.
Journal ArticleDOI
Nanoparticles: From synthesis to applications and beyond.
TL;DR: In this paper , the authors summarize current trends in the nanoparticle synthesis and characterization and interpret the stability of nanoparticles in various media from aqueous solutions to biological milieu important for the in vitro and in vivo studies.
Journal ArticleDOI
Blood and Synovial Microparticles as Revealed by Atomic Force and Scanning Electron Microscope
Ita Junkar,Vid Šuštar,Mojca Frank,Vid Janša,Apolonija Bedina Zavec,Blaz Rozman,Miran Mozetič,Henry Hägerstrand,Veronika Kralj-Iglič +8 more
TL;DR: A pilot study results involving atomic force microscope (AFM) and scanning electron microscope (SEM) images of the material isolated from peripheral blood of healthy donors and from synovial fluid of patients with psoriatic arthritis and rheumatoid arthritis, which is expected to contain microvesicles are presented.
Journal ArticleDOI
The antibiotic vancomycin induces complexation and aggregation of gastrointestinal and submaxillary mucins
Vlad Dinu,Yudong Lu,Nicola Weston,Ryan Lithgo,Hayley Coupe,Guy A. Channell,Gary G. Adams,Gary G. Adams,Amelia Torcello Gómez,Carlos Sabater,Carlos Sabater,Alan R. Mackie,Christopher D. J. Parmenter,Ian D. Fisk,Mary K. Phillips-Jones,Stephen E. Harding +15 more
TL;DR: This is the first study to demonstrate strong interactions between vancomycin and gastric and intestinal mucins, resulting in very large aggregates and depletion of macromolecular mucin and occurring at concentrations relevant to oral dosing.
Journal ArticleDOI
Interaction Between Equally Charged Membrane Surfaces Mediated by Positively and Negatively Charged Macro-Ions
Šárka Perutková,Mojca Frank,Klemen Bohinc,Goran Bobojevic,Jasna Zelko,Blaž Rozman,Veronika Kralj-Iglič,Aleš Iglič +7 more
TL;DR: In this work, theory was put forward to describe an IgG antibody-mediated attractive interaction between negatively charged membrane surfaces which was observed in experiments on giant phospholipid vesicles with cardiolipin-containing membranes.
References
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