Journal ArticleDOI
Autotransfusion of hemothorax blood in trauma patients: Is it the same as fresh whole blood?
Marc A. Salhanick,Michael G. Corneille,Russell A. Higgins,John D. Olson,Joel E. Michalek,Chantal R. Harrison,Ronald M. Stewart,Daniel L. Dent +7 more
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TLDR
Hemothorax blood contains significantly decreased coagulation factors and has lower hemoglobin when compared with venous blood.Abstract:
Background Autotransfusable shed blood has been poorly characterized in trauma and may have similarities to whole blood with additional benefits. Methods This was a prospective descriptive study of adult patients from whom ≥50 mL of blood was drained within the first 4 hours after chest tube placement. Pleural and venous blood samples were analyzed for coagulation, hematology, and electrolytes. Results Twenty-two subjects were enrolled in 9 months. The following measured coagulation factors of hemothorax were significantly depleted compared with venous blood: international normalized ratio (>9 in contrast to 1.1, P 180 in contrast to 28.5 seconds, P P P = .003), hemoglobin (9.3 in contrast to 11.8 g/dL, P = .004), and platelet count (53 in contrast to 174 K/μL, P Conclusions Hemothorax blood contains significantly decreased coagulation factors and has lower hemoglobin when compared with venous blood.read more
Citations
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Book ChapterDOI
Pneumothorax, Chylothorax, Hemothorax and Fibrothorax
Richard Light,Yun Chor Lee +1 more
Journal ArticleDOI
Early autologous fresh whole blood transfusion leads to less allogeneic transfusions and is safe.
Peter Rhee,Kenji Inaba,Viraj Pandit,Mazhar Khalil,Stefano Siboni,Gary Vercruysse,Narong Kulvatunyou,Andrew Tang,Anum Asif,Terence O'Keeffe,Bellal Joseph +10 more
TL;DR: The autologous transfusion of the patient’s shed blood collected through chest tubes for hemothorax was found to be safe without complications in this study and would help in designing larger prospective multicenter studies to determine whether this practice is truly safe and effective.
Journal ArticleDOI
Traumatic Hemothorax Blood Contains Elevated Levels of Microparticles that are Prothrombotic but Inhibit Platelet Aggregation
Thomas A. Mitchell,Maryanne C. Herzig,Chriselda G. Fedyk,Marc A. Salhanick,Aaron T. Henderson,Bijaya K. Parida,Nicolas Prat,Daniel L. Dent,Martin G. Schwacha,Andrew P. Cap +9 more
TL;DR: Autologous transfusion of shed traumatic hemothorax blood may induce a range of undesirable effects in patients with acute traumatic coagulopathy, and plasma hypercoagulability is induced that is likely related to increased tissue factor and phosphatidylserine expression originating from cell-derived MP.
Journal ArticleDOI
A small amount can make a difference: a prospective human study of the paradoxical coagulation characteristics of hemothorax
W. Zachary Smith,Hannah B. Harrison,Marc A. Salhanick,Russell A. Higgins,Alfonso Ortiz,John D. Olson,Martin G. Schwacha,Chantal R. Harrison,Jayson D. Aydelotte,Ronald M. Stewart,Daniel L. Dent +10 more
TL;DR: An evacuated hemothorax does not vary in composition significantly with time and is incoagulable alone, and Mixing studies with hemothsorax plasma increased coagulation, raising safety concerns.
References
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Journal ArticleDOI
Perioperative blood transfusion and blood conservation in cardiac surgery: the Society of Thoracic Surgeons and The Society of Cardiovascular Anesthesiologists clinical practice guideline.
Victor A. Ferraris,Suellen P. Ferraris,Sibu P. Saha,Eugene A. Hessel,Constance K. Haan,B. David Royston,Charles R. Bridges,Robert S.D. Higgins,George J. Despotis,Jeremiah R. Brown,Bruce D. Spiess,Linda Shore-Lesserson,Mark Stafford-Smith,C. David Mazer,Elliott Bennett-Guerrero,Steven E. Hill,Simon C. Body +16 more
TL;DR: Based on available evidence, institution-specific protocols should screen for high- risk patients, as blood conservation interventions are likely to be most productive for this high-risk subset of patients.
Journal ArticleDOI
Clinical Practice Guideline: Red Blood Cell Transfusion in Adult Trauma and Critical Care
Lena M. Napolitano,Stanley Kurek,Fred A. Luchette,Howard L. Corwin,Philip S. Barie,Samuel A. Tisherman,Paul C. Hébert,Gary L. Anderson,Michael R. Bard,William J. Bromberg,William C. Chiu,Mark D. Cipolle,Keith D. Clancy,Lawrence N. Diebel,William S. Hoff,K. Michael Hughes,Imtiaz A. Munshi,Donna Nayduch,Rovinder Sandhu,Jay A. Yelon +19 more
TL;DR: Evidence-based recommendations regarding the use of RBC transfusion in adult trauma and critical care will provide important information to critical care practitioners.
Journal ArticleDOI
Impact of allogenic packed red blood cell transfusion on nosocomial infection rates in the critically ill patient
R. W. Taylor,Lisa Manganaro,Jacklyn O’Brien,Steven Trottier,Nadeem Parkar,Christopher Veremakis +5 more
TL;DR: Transfusion of packed red blood cells is associated with nosocomial infection and this association continues to exist when adjusted for probability of survival and age, and mortality rates and length of intensive care unit and hospital stay are significantly increased in transfused patients.
Journal ArticleDOI
Warm fresh whole blood transfusion for severe hemorrhage: U.S. military and potential civilian applications.
TL;DR: For patients with life-threatening hemorrhage at risk for massive transfusion, the risk:benefit ratio of warm fresh whole blood transfusion favors its use, if complete component therapy is not available or not adequately correcting coagulopathy.
Journal ArticleDOI
Autotransfusion of shed mediastinal blood after cardiac surgery: A prospective study
Hartzell V. Schaff,Jerome Hauer,William R. Bell,Timothy J. Gardner,James S. Donahoo,Vincent L. Gott,Robert K. Brawley +6 more
TL;DR: In this study, autotransfusion of shed mediastinal blood was safe and simple, it significantly reduced bank blood requirements and resulted in substantial financial savings for the patients and the hospital.