Journal ArticleDOI
A small amount can make a difference: a prospective human study of the paradoxical coagulation characteristics of hemothorax
W. Zachary Smith,Hannah B. Harrison,Marc A. Salhanick,Russell A. Higgins,Alfonso Ortiz,John D. Olson,Martin G. Schwacha,Chantal R. Harrison,Jayson D. Aydelotte,Ronald M. Stewart,Daniel L. Dent +10 more
TLDR
An evacuated hemothorax does not vary in composition significantly with time and is incoagulable alone, and Mixing studies with hemothsorax plasma increased coagulation, raising safety concerns.Abstract:
Background The evacuated hemothorax has been poorly described because it varies with time, it has been found to be incoagulable, and its potential effect on the coagulation cascade during autotransfusion is largely unknown. Methods This is a prospective descriptive study of adult patients with traumatic chest injury necessitating tube thoracostomy. Pleural and venous samples were analyzed for coagulation, hematology, and electrolytes at 1 to 4 hours after drainage. Pleural samples were also analyzed for their effect on the coagulation cascade via mixing studies. Results Thirty-four subjects were enrolled with a traumatic hemothorax. The following measured coagulation factors were significantly depleted compared with venous blood: international normalized ratio (>9 vs 1.1) (P 180 vs 24.5 seconds) (P Conclusions An evacuated hemothorax does not vary in composition significantly with time and is incoagulable alone. Mixing studies with hemothorax plasma increased coagulation, raising safety concerns.read more
Citations
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Journal ArticleDOI
Early autologous fresh whole blood transfusion leads to less allogeneic transfusions and is safe.
Peter Rhee,Kenji Inaba,Viraj Pandit,Mazhar Khalil,Stefano Siboni,Gary Vercruysse,Narong Kulvatunyou,Andrew Tang,Anum Asif,Terence O'Keeffe,Bellal Joseph +10 more
TL;DR: The autologous transfusion of the patient’s shed blood collected through chest tubes for hemothorax was found to be safe without complications in this study and would help in designing larger prospective multicenter studies to determine whether this practice is truly safe and effective.
Journal ArticleDOI
Traumatic Hemothorax Blood Contains Elevated Levels of Microparticles that are Prothrombotic but Inhibit Platelet Aggregation
Thomas A. Mitchell,Maryanne C. Herzig,Chriselda G. Fedyk,Marc A. Salhanick,Aaron T. Henderson,Bijaya K. Parida,Nicolas Prat,Daniel L. Dent,Martin G. Schwacha,Andrew P. Cap +9 more
TL;DR: Autologous transfusion of shed traumatic hemothorax blood may induce a range of undesirable effects in patients with acute traumatic coagulopathy, and plasma hypercoagulability is induced that is likely related to increased tissue factor and phosphatidylserine expression originating from cell-derived MP.
Journal Article
Comparative analysis of autologous blood transfusion and allogeneic blood transfusion in surgical patients.
TL;DR: Wang et al. as discussed by the authors investigated the application effects of autologous blood transfusion and allogeneic transfusion in surgically treated patients receiving spine surgery, abdomen surgery and ectopic pregnancy surgery.
Journal ArticleDOI
An experimental model of hemothorax autotransfusion: Impact on coagulation
Hannah B. Harrison,William Zachary Smith,Marc A. Salhanick,Russell A. Higgins,Alfonso Ortiz,John D. Olson,Martin G. Schwacha,Chantal R. Harrison,Jayson D. Aydelotte,Ronald M. Stewart,Daniel L. Dent +10 more
TL;DR: It is hypothesized that when HTX is mixed with a patient's own plasma, the mixture will demonstrate hypercoagulability, and autotransfusion of HTX would likely produce a hyper coagulable state in vivo, and should be used in place of other blood products to resuscitate a trauma patient.
References
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Reference EntryDOI
Cell salvage for minimising perioperative allogeneic blood transfusion
TL;DR: The results suggest cell salvage is efficacious in reducing the need for allogeneic red cell transfusion in adult elective cardiac and orthopaedic surgery and the methodological quality of trials was poor.
Journal ArticleDOI
Clinical practice guideline: red blood cell transfusion in adult trauma and critical care.
Lena M. Napolitano,Stanley Kurek,Fred A. Luchette,Gary L. Anderson,Michael R. Bard,William J. Bromberg,William C. Chiu,Mark D. Cipolle,Keith D. Clancy,Lawrence N. Diebel,William S. Hoff,K. Michael Hughes,Imtiaz A. Munshi,Donna Nayduch,Rovinder Sandhu,Jay A. Yelon,Howard L. Corwin,Philip S. Barie,Samuel A. Tisherman,Paul C. Hébert +19 more
TL;DR: Red blood cell (RBC) transfusion is common in critically ill and injured patients and the data from these studies from diverse locations in Western Europe, Canada, the United States and Asia show widespread use.
Journal ArticleDOI
Transfusion of aged packed red blood cells results in decreased tissue oxygenation in critically injured trauma patients.
TL;DR: There was a decrease in peripheral tissue oxygenation in patients receiving older red blood cells and factors in stored blood may influence the peripheral vasculature and oxygen delivery.
Journal ArticleDOI
Reinfusion of Shed Blood after Orthopaedic Procedures in Children and Adolescents
TL;DR: The reinfusion of unwashed, filtered shed blood that was as much as 15 per cent of the total blood volume proved to be a safe technique after major orthopaedic procedures.
Journal ArticleDOI
Adverse effects of postoperative infusion of shed mediastinal blood
Roger A. Vertrees,Vincent R. Conti,Scott D. Lick,Joseph B. Zwischenberger,Laura B. McDaniel,Gerald Shulman +5 more
TL;DR: The data support those in previous studies that direct infusion of shed mediastinal blood does not save substantial amounts of autologous red cells and can cause a delayed coagulopathy and other adverse effects that may be harmful to patients postoperatively.