Open AccessJournal Article
Baroreflex deficiency induces additional impairment of vagal tone, diastolic function and calcium handling proteins after myocardial infarction.
Cristiano Mostarda,Bruno Rodrigues,Alessandra Medeiros,Edson Dias Moreira,Ivana C. Moraes-Silva,Patricia Chakur Brum,Kátia De Angelis,Maria Claudia Irigoyen +7 more
TLDR
The findings strongly suggest that previous arterial baroreflex deficiency may induce additional impairment of vagal tonus, which was associated with calcium handling proteins abnormalities, probably triggering ventricular diastolic dysfunction after MI in rats.Abstract:
Baroreflex dysfunction has been considered an important mortality predictor after myocardial infarction (MI). However, the impact of baroreflex deficiency prior to MI on tonic autonomic control and cardiac function, and on the profile of proteins associated with intracellular calcium handling has not yet been studied. The aim of the present study was to analyze how the impairment of baroreflex induced by sinoaortic denervation (SAD) prior to MI in rats affects the tonic autonomic control, ventricular function and cardiomyocyte calcium handling proteins. After 15 days of following or SAD surgery, rats underwent MI. Echocardiographic, hemodynamic, autonomic and molecular evaluations were performed 90 days after MI. Baroreflex impairment led to additional damage on: left ventricular remodeling, diastolic function, vagal tonus and intrinsic heart rate after MI. The loss of vagal component of the arterial baroreflex and vagal tonus were correlated with changes in the cardiac proteins involved in intracellular calcium homeostasis. Furthermore, additional increase in sodium calcium exchanger expression levels was associated with impaired diastolic function in experimental animals. Our findings strongly suggest that previous arterial baroreflex deficiency may induce additional impairment of vagal tonus, which was associated with calcium handling proteins abnormalities, probably triggering ventricular diastolic dysfunction after MI in rats.read more
Citations
More filters
Journal ArticleDOI
Affective reactivity to daily stress and 20-year mortality risk in adults with chronic illness: Findings from the National Study of Daily Experiences.
TL;DR: The results suggest that greater increases in negative affect in response to stress in everyday life may have long-term consequences for longevity, particularly for individuals with chronic illness.
Book ChapterDOI
Myocardial Infarction and Exercise Training: Evidence from Basic Science.
Ivana C. Moraes-Silva,Bruno Rodrigues,Hélio José Coelho-Júnior,Daniele Jardim Feriani,Maria Claudia Irigoyen +4 more
TL;DR: This chapter presents a brief review of MI pathophysiology followed by an updated discussion of the most relevant discoveries regarding ET and MI in basic science.
Journal ArticleDOI
The role of the baroreflex and parasympathetic nervous system in fructose-induced cardiac and metabolic alterations
TL;DR: Chronic fructose overload induced severe baroreflex impairment, and the compensatory enhancement in parasympathetic function in SAD rats submitted to fructose intake may point out the possibility of use of approaches that improve vagal function as therapeutic target to attenuate fructose-induced cardiometabolic dysfunctions.
Journal ArticleDOI
Cholinergic Stimulation by Pyridostigmine Bromide Before Myocardial Infarction Prevent Cardiac and Autonomic Dysfunction.
C. A. Barboza,André Rinaldi Fukushima,Nicolle Martins Carrozzi,Jacqueline Freire Machi,Paulo Magno Martins Dourado,Cristiano Mostarda,Maria Claudia Irigoyen,Lubov Nathanson,Mariana Morris,Erico Chagas Caperuto,Bruno Rodrigues +10 more
TL;DR: Prior treatment with PYR prevents impairment of the autonomic nervous system after MI, which may be associated with the attenuated expression of inflammatory factors and heart dysfunction.
References
More filters
Journal ArticleDOI
Third universal definition of myocardial infarction
Kristian Thygesen,Joseph S. Alpert,Allan S. Jaffe,Maarten L. Simoons,Bernard R. Chaitman,Harvey D. White +5 more
TL;DR: Information on MI rates can provide useful information regarding the burden of CAD within and across populations, especially if standardized data are collected in a manner that …
Journal ArticleDOI
Heart Disease and Stroke Statistics—2014 Update A Report From the American Heart Association
Alan S. Go,Dariush Mozaffarian,Véronique L. Roger,Emelia J. Benjamin,Jarett D. Berry,Michael J. Blaha,Shifan Dai,Earl S. Ford,Caroline S. Fox,Sheila Franco,Heather J. Fullerton,Cathleen Gillespie,Susan M. Hailpern,John A. Heit,Virginia J. Howard,Mark D. Huffman,Suzanne E. Judd,Brett M. Kissela,Steven J. Kittner,Daniel T. Lackland,Judith H. Lichtman,Lynda D. Lisabeth,Rachel H. Mackey,David J. Magid,Gregory M. Marcus,Ariane Marelli,David B. Matchar,Darren K. McGuire,Emile R. Mohler,Claudia S. Moy,Michael E. Mussolino,Robert W. Neumar,Graham Nichol,Dilip K. Pandey,Nina P. Paynter,Matthew J. Reeves,Paul D. Sorlie,Joel Stein,Amytis Towfighi,Tanya N. Turan,Salim S. Virani,Nathan D. Wong,Daniel Woo,Melanie B. Turner +43 more
TL;DR: Author(s): Go, Alan S; Mozaffarian, Dariush; Roger, Veronique L; Benjamin, Emelia J; Berry, Jarett D; Blaha, Michael J; Dai, Shifan; Ford, Earl S; Fox, Caroline S; Franco, Sheila; Fullerton, Heather J; Gillespie, Cathleen; Hailpern, Susan M; Heit, John A; Howard, Virginia J; Huffman, Mark D; Judd
Journal ArticleDOI
Decreased heart rate variability and its association with increased mortality after acute myocardial infarction
Robert E. Kleiger,Robert E. Kleiger,Robert E. Kleiger,J. Philip Miller,J. Philip Miller,J. Philip Miller,J.Thomas Bigger,J.Thomas Bigger,J.Thomas Bigger,Arthur J. Moss,Arthur J. Moss,Arthur J. Moss +11 more
TL;DR: HR variability remained a significant predictor of mortality after adjusting for clinical, demographic, other Holter features and ejection fraction, and a hypothesis to explain this finding is that decreased HR variability correlates with increased sympathetic or decreased vagal tone, which may predispose to ventricular fibrillation.
Journal ArticleDOI
Baroreflex sensitivity and heart-rate variability in prediction of total cardiac mortality after myocardial infarction
TL;DR: The ATRAMI study as discussed by the authors provides clinical evidence that after myocardial infarction the analysis of vagal reflexes has significant prognostic value independently of LVEF and ventricular arrhythmias and that it significantly adds to the prognosis value of heartrate variability.
Journal ArticleDOI
The human sympathetic nervous system: its relevance in hypertension and heart failure
TL;DR: The blood pressure lowering achieved with carotid baroreceptor stimulation and with the renal denervation device affirms the importance of the sympathetic nervous system in hypertension pathogenesis, and perhaps suggests a wider role for anti-adrenergic antihypertensives, such as the imidazoline drug class which act within the CNS to inhibit central sympathetic outflow.