Journal ArticleDOI
Base-mediated alternate route for multi-functionalized allylbenzenes using ring transformation strategy
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TLDR
A simple yet innovative approach for the construction of multi-substituted allylbenzenes 14, 16 and 18 with "donor-acceptor" functionalities has been delineated through base-mediated ring transform.About:
This article is published in Synthetic Communications.The article was published on 2020-06-25. It has received 7 citations till now.read more
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Synthesis, spectral characterization and photophysical studies of tetrahydroquinolines
TL;DR: In this paper, a metal-free, ultrasound-assisted, fast synthesis of fluorescent N-Boc-protected 1,2,3,4-tetrahydroquinolines 9a-p was described through carbanion-induced ring transformation of 6-aryl-2H-pyran-2-ones with tert-butyl 3-oxopiperidine-1-carboxylate under basic condition.
Journal ArticleDOI
Investigation of Pharmaceutical Importance of 2H-Pyran-2-One Analogues via Computational Approaches
Samata E. Shetgaonkar,Shiva Prasad Kollur,Renjith Raveendran Pillai,Karthick Thangavel,Sanja J. Armaković,Stevan Armaković,Chandan Shivamallu,Raghavendra G. Amachawadi,Asad Syed,Abdallah M. Elgorban,Ali H. Bahkali,Fateh V. Singh +11 more
TL;DR: In this paper, high functionalized spirocyclic ketals were synthesized through asymmetric oxidative spirocycle via carbanion-induced ring transformation of 2H-pyran-2-ones with 1,4-cyclohexandione monoethyleneketal under alkaline conditions.
Journal ArticleDOI
Metal-free synthesis and single crystal X-ray analysis of 4-aryl-6-hydroxy-2Η-pyran-2-cyanomethylenes
TL;DR: In this article, the synthesis of 4-aryl-2H-pyran-2-ones 7 was accomplished by rearrangement of 6-aryl 2H-Pyranones 5 with ethyl cyanoacetate 6 in the presence of a base in DMF at room temperature.
Journal ArticleDOI
Ultrasound-Assisted Synthesis, Photophysical Behaviour and Single Crystal X-Ray Analysis of Highly Functionalized Prenylarenes
Manjula Krishnan,Fateh V. Singh +1 more
TL;DR: In this paper , a novel series linear prenylarenes 17 incorporated with donor-acceptor functionalities is described via carbanion-induced ring transformation of 4-amino-6-aryl-3-cyano-2H-pyran-2-ones with 6-methylhept-5-en-2.2-one at room temperature with high yields.
Journal ArticleDOI
Ultrasound-Assisted Metal-Free Synthesis of Functionalized 1,2-Teraryls by Ring Transformation Methodology
Manjula Krishnan,Fateh V. Singh +1 more
TL;DR: In this article , the ultrasound assisted carbanion induced ring transformation of 4-amino-6-aryl-3-cyano-2H-pyran-2-ones using (E)-styryl acetate in the presence of KOH and DMF at room temperature is presented as an alternative strategy for the synthesis of functionalized 1,2-teraryls in high yields.
References
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Journal ArticleDOI
Natural and synthetic 2H-pyran-2-ones and their versatility in organic synthesis☆
Atul Goel,Vishnu Ji Ram +1 more
TL;DR: An overview of the natural presence and development of the chemistry of the 2 H -pyran-2-one ring system is delineated in this article, where 363 references are provided.
Journal ArticleDOI
Isomerization of allylbenzenes.
Mohammad Hassam,Abu Taher,Gareth E. Arnott,Ivan R. Green,Willem A. L. van Otterlo,Willem A. L. van Otterlo +5 more
TL;DR: The proposed Base-Mediated Reaction Mechanism answers the question of both the retention and the inversion of stereochemistry for the simple exchange reaction giving back I and leads to two “conformations” of the chiral alkene I that will lead to either the E or the Z allylic anions as shown.
Journal ArticleDOI
A review on anti-inflammatory activity of phenylpropanoids found in essential oils.
Rita de Cássia da Silveira e Sá,Luciana Nalone Andrade,Rafael dos Reis Barreto de Oliveira,Damião Pergentino de Sousa +3 more
TL;DR: An overview of the anti-inflammatory action exerted by phenylpropanoids from essential oils is presented and possible mechanisms of action involved in theAnti-inflammatory response, assessed through specific experimental models are discussed.
Journal ArticleDOI
(E)-Methylisoeugenol and elemicin: antibacterial components of Daucus carota L. essential oil against Campylobacter jejuni.
Paul-Georges Rossi,Lei Bao,Anne Luciani,Jean Panighi,Jean-Marie Desjobert,Jean Costa,Joseph Casanova,Jean-Michel Bolla,Liliane Berti +8 more
TL;DR: The essential oil of wild Daucus carota L. obtained from aerial parts at the end of the flowering stage was reported as antimicrobial against the human enteropathogen Campylobacter jejuni and the active compounds of the essential oil, subjected to GC, GC-MS, and (13)C NMR analysis were identified.
Journal ArticleDOI
Evaluation of the Antimicrobial, Antioxidant, and Anti-Inflammatory Activities of Hydroxychavicol for Its Potential Use as an Oral Care Agent
Seema Sharma,Inshad Ali Khan,Intzar Ali,Furqan Ali,Manoj Kumar,Ashwani Kumar,Rakesh Kamal Johri,Sheikh Tasduq Abdullah,Sarang Bani,Anjali Pandey,Krishan Avtar Suri,Bishan Datt Gupta,Naresh Kumar Satti,Prabhu Dutt,Ghulam Nabi Qazi +14 more
TL;DR: Hydxychavicol isolated from the chloroform extraction of aqueous extract of Piper betle leaves showed inhibitory activity against oral cavity pathogens and potent antioxidant and anti-inflammatory activities, suggesting it has great potential for use in mouthwash for preventing and treating oral infections.