Beneficial Role of Coffee and Caffeine in Neurodegenerative Diseases: A Minireview
Yenisetti Sc,Muralidhara,Muralidhara +2 more
- Vol. 3, Iss: 2, pp 407-422
TLDR
In this minireview, an attempt has been made to discuss the various evidences which are mainly derived from animal and cell models supporting the beneficial effects of caffeine, including caffeine, chlorogenic acid, caffeic acid, and hydroxy hydroquinone.Abstract:
Coffee is among the most widespread and healthiest beverages in the world. Coffee typically contains more caffeine than most other beverages, and is widely and frequently consumed. Thus, it contributes significantly to the overall caffeine consumption within the general population, particularly in adults. Controversies regarding its benefits and risks still exist as reliable evidence is becoming available supporting its health-promoting potential. Several lines of evidence have highlighted the beneficial effects towards several disease conditions including Type II diabetes, hepatitis C virus, hepatocellular carcinoma, nonalcoholic fatty liver disease and neurodegenerative disorders such as Alzheimer's disease (AD), Parkinson's disease (PD) and Amyotrophic Lateral Sclerosis (ALS). The health-promoting properties of coffee are largely attributed to its rich phytochemistry, including caffeine, chlorogenic acid, caffeic acid, and hydroxy hydroquinone. In this minireview, an attempt has been made to discuss the various evidences which are mainly derived from animal and cell models. Various mechanisms chiefly responsible for the beneficial effects of caffeine have also been briefly outlined. A short note on the undesirable effects of excessive coffee intakes is also presented.read more
Citations
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Health benefits of methylxanthines in neurodegenerative diseases.
TL;DR: Data is reviewed that appraise the preventive and even therapeutic potential of MTXs in a variety of neurodegenerative diseases, and the use of the methylxanthine chemical moiety as a basis for the development of new and more efficacious drugs.
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Whole-blood metabolomics of dementia patients reveal classes of disease-linked metabolites.
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TL;DR: A unique and comprehensive review that will provide a brief overview of sources, utilization, healthful as well as harmful effect of caffeine to the readers.
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Methylxanthines and Neurodegenerative Diseases: An Update.
Daniel Janitschke,Anna A. Lauer,Cornel M Bachmann,Heike S. Grimm,Tobias Hartmann,Marcus O. W. Grimm +5 more
TL;DR: In this paper, the impact of methylxanthines in neurodegenerative diseases has been extensively studied and several new aspects have been elucidated, such as adenosine receptor antagonism, phosphodiesterase inhibition, effects on the cholinergic system, wnt signaling, histone deacetylase activation and gene regulation.
References
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Journal ArticleDOI
Effects of caffeine on human health.
TL;DR: It is concluded that for the healthy adult population, moderate daily caffeine intake is not associated with adverse effects such as general toxicity, cardiovascular effects, effects on bone status and calcium balance, changes in adult behaviour, increased incidence of cancer and effects on male fertility.
Journal ArticleDOI
The PARP Side of the Nucleus: Molecular Actions, Physiological Outcomes, and Clinical Targets
Raga Krishnakumar,W. Lee Kraus +1 more
TL;DR: The abundant nuclear enzyme PARP-1, a multifunctional regulator of chromatin structure, transcription, and genomic integrity, plays key roles in a wide variety of processes in the nucleus.
Journal ArticleDOI
Caffeine (1, 3, 7-trimethylxanthine) in Foods: A Comprehensive Review on Consumption, Functionality, Safety, and Regulatory Matters
TL;DR: Performance benefits attributed to caffeine include physical endurance, reduction of fatigue, and enhancing mental alertness and concentration, however, the caloric contribution of caffeine-sweetened beverages needs to be considered in the overall energy balance.
Journal ArticleDOI
Food sources and intakes of caffeine in the diets of persons in the United States
TL;DR: Coffee was the major source of caffeine in the diets of adults, whereas soft drinks were the primary source for children and teens, and caffeine consumption increased among people aged 2 to 54 years.
Journal ArticleDOI
Association of Coffee Drinking with Total and Cause-Specific Mortality
TL;DR: In this large prospective study, coffee consumption was inversely associated with total and cause-specific mortality and, after adjustment for tobacco-smoking status and other potential confounders, there was a significant inverse association between coffee consumption and mortality.