Bidirectional modulation of anxiety-related and social behaviors by amygdala projections to the medial prefrontal cortex
Ada C. Felix-Ortiz,Anthony Burgos-Robles,Neha D. Bhagat,Neha D. Bhagat,Christopher A. Leppla,Kay M. Tye +5 more
TLDR
A causal relationship between activity in the BLA-mPFC pathway and the bidirectional modulation of anxiety-related and social behaviors is established.Citations
More filters
Neuroscience 細胞死：最近の知見
TL;DR: In this paper, the authors describe a scenario where a group of people are attempting to find a solution to the problem of "finding the needle in a haystack" in the environment.
Journal ArticleDOI
Direct Ventral Hippocampal-Prefrontal Input Is Required for Anxiety-Related Neural Activity and Behavior.
Nancy Padilla-Coreano,Scott S. Bolkan,Georgia M. Pierce,Dakota R. Blackman,William D. Hardin,Alvaro L. Garcia-Garcia,Timothy Spellman,Joshua A. Gordon +7 more
TL;DR: A specific role is revealed for the vHPC-mPFC projection in anxiety-related behavior and the spatial representation of aversive information within the mPFC.
Journal ArticleDOI
A Comprehensive Overview on Stress Neurobiology: Basic Concepts and Clinical Implications.
Lívea Dornela Godoy,Matheus Teixeira Rossignoli,Polianna Delfino-Pereira,N. Garcia-Cairasco,Eduardo H.L. Umeoka +4 more
TL;DR: The identification of neuronal circuits of stress, as well as their interaction with mediator molecules over time is critical, not only for understanding the physiological stress responses, but also to understand their implications on mental health.
Journal ArticleDOI
Amygdala Inputs to Prefrontal Cortex Guide Behavior Amid Conflicting Cues of Reward and Punishment
Anthony Burgos-Robles,Eyal Y. Kimchi,Eyal Y. Kimchi,Ehsan M. Izadmehr,Mary Jane Porzenheim,William A Ramos-Guasp,Edward H. Nieh,Ada C. Felix-Ortiz,Praneeth Namburi,Christopher A. Leppla,Kara N. Presbrey,Kavitha K. Anandalingam,Pablo A Pagan-Rivera,Melodi Anahtar,Anna Beyeler,Kay M. Tye +15 more
TL;DR: The BLA→PL circuit is critical in governing the selection of behavioral responses in the face of competing signals, and optogenetic and chemogenetic inhibition reduced freezing.
Journal ArticleDOI
Combined Social and Spatial Coding in a Descending Projection from the Prefrontal Cortex
Malavika Murugan,Hee Jae Jang,Michelle Park,Ellia M. Miller,Julia Cox,Joshua P. Taliaferro,Nathan F. Parker,Varun Bhave,Hong Hur,Yupu Liang,Alexander R. Nectow,Jonathan W. Pillow,Ilana B. Witten +12 more
TL;DR: An unexpected combination of social and spatial information within the prelimbic cortex may contribute to social behavior by supporting social-spatial learning.
References
More filters
Journal ArticleDOI
Emotion Circuits in the Brain
TL;DR: The field of neuroscience has, after a long period of looking the other way, again embraced emotion as an important research area, and much of the progress has come from studies of fear, and especially fear conditioning as mentioned in this paper.
Journal ArticleDOI
Millisecond-timescale, genetically targeted optical control of neural activity.
TL;DR: In this paper, the authors adapted the naturally occurring algal protein Channelrhodopsin-2, a rapidly gated light-sensitive cation channel, by using lentiviral gene delivery in combination with high-speed optical switching to photostimulate mammalian neurons.
Journal ArticleDOI
The role of the amygdala in fear and anxiety
TL;DR: The idea that the amygdala, and its many efferent projections, may represent a central fear system involved in both the expression and acquisition of conditioned fear is summarized.
Journal ArticleDOI
Stress, memory and the amygdala
TL;DR: The unique features of stress-induced plasticity in the amygdala, in association with changes in other brain regions, could have long-term consequences for cognitive performance and pathological anxiety exhibited in people with affective disorders.