Bidirectional prefrontal-hippocampal interactions support context-guided memory
TLDR
Functional connectivity analysis indicated a flow of contextual information from the hippocampus to prefrontal cortex upon the rat's entry into the spatial context, consistent with prefrontal control over the retrieval of context-appropriate hippocampal memory representations.Abstract:
We compared the dynamics of hippocampal and prefrontal interactions in rats as they used spatial contexts to guide the retrieval of object memories. Functional connectivity analysis indicated a flow of contextual information from the hippocampus to prefrontal cortex upon the rat's entry into the spatial context. Conversely, upon the onset of object sampling, the direction of information flow reversed, consistent with prefrontal control over the retrieval of context-appropriate hippocampal memory representations.read more
Citations
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Journal ArticleDOI
Prefrontal-hippocampal interactions in episodic memory
TL;DR: These findings suggest a model of how the hippocampus and PFC, along with their intermediaries, operate as a system that uses the current context of experience to retrieve relevant memories.
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Viewpoints: how the hippocampus contributes to memory, navigation and cognition
TL;DR: The hippocampus serves a critical function in memory, navigation, and cognition and John Lisman leads a group of researchers in a dialog on shared and distinct viewpoints on the hippocampus.
Journal ArticleDOI
Concussion, microvascular injury, and early tauopathy in young athletes after impact head injury and an impact concussion mouse model.
Chad A. Tagge,Andrew M. Fisher,Olga Minaeva,Amanda Gaudreau-Balderrama,Juliet A. Moncaster,Xiao-Lei Zhang,Mark W. Wojnarowicz,Noel Casey,Haiyan Lu,Olga N. Kokiko-Cochran,Sudad Saman,Maria Ericsson,Kristen D. Onos,Ronel Veksler,Vladimir V. Senatorov,Asami Kondo,Xiao Z. Zhou,Omid Miry,Linnea R. Vose,Katisha R. Gopaul,Chirag Upreti,Christopher J. Nowinski,Robert C. Cantu,Robert C. Cantu,Victor E. Alvarez,Victor E. Alvarez,Audrey M. Hildebrandt,Erich S. Franz,Janusz Konrad,James A. Hamilton,Ning Hua,Yorghos Tripodis,Andrew T. Anderson,Gareth R. Howell,Daniela Kaufer,Daniela Kaufer,Garth F. Hall,Kun P. Lu,Richard M. Ransohoff,Robin O. Cleveland,Neil W. Kowall,Neil W. Kowall,Thor D. Stein,Thor D. Stein,Bruce T. Lamb,Bertrand R. Huber,William C. Moss,Alon Friedman,Alon Friedman,Patric K. Stanton,Ann C. McKee,Ann C. McKee,Lee E. Goldstein +52 more
TL;DR: Using neuropathological analyses of brains from teenage athletes, a new mouse model of concussive impact injury, and computational simulations, Tagge and colleagues show that head injuries can induce TBI and early CTE pathologies independent of concussion.
Journal ArticleDOI
Oscillatory Dynamics of Prefrontal Cognitive Control
Randolph F. Helfrich,Randolph F. Helfrich,Randolph F. Helfrich,Robert T. Knight,Robert T. Knight +4 more
TL;DR: Recent findings that suggest that the functional architecture of cognition is profoundly rhythmic are reviewed and it is proposed that the PFC serves as a conductor to orchestrate task-relevant large-scale networks.
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Dynamic updating of hippocampal object representations reflects new conceptual knowledge.
TL;DR: The findings suggest that the brain reorganizes when concepts change and provide support for a neurocomputational theory of concept formation and propose that when task goals change, object representations in HPC can be organized in new ways, resulting in updated concepts that highlight the features most critical to the new goal.
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