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Bifidobacterium Bifidum Reduces Apoptosis in the Intestinal Epithelium in
Ludmila Khailova,Sarah Mount Patrick,Kelly M. Arganbright,Melissa D. Halpern,Toshi Kinouchi,Bohuslav Dvorak +5 more
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The article was published on 2010-01-01 and is currently open access. It has received 107 citations till now. The article focuses on the topics: Bifidobacterium bifidum & Intestinal epithelium.read more
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Probiotic Mechanisms of Action
Miriam Bermudez-Brito,Julio Plaza-Díaz,Sergio Muñoz-Quezada,Carolina Gomez-Llorente,Angel Gil +4 more
TL;DR: Probiotics modes of action focusing on how gut microbes influence the host are explored, with a clear understanding of these mechanisms allowing for appropriate probiotic strain selection for specific applications and may uncover novel probiotic functions.
Journal ArticleDOI
Mechanisms of Action of Probiotics
Julio Plaza-Díaz,Francisco Javier Ruiz-Ojeda,Mercedes Gil-Campos,Mercedes Gil-Campos,Angel Gil +4 more
TL;DR: The aim of the present work was to review the main mechanisms of action of probiotics, including colonization and normalization of perturbed intestinal microbial communities in children and adults; competitive exclusion of pathogens and bacteriocin production; modulation of fecal enzymatic activities associated with the metabolization of biliary salts and inactivation of carcinogens and other xenobiotics.
Journal ArticleDOI
Genomic encyclopedia of type strains of the genus Bifidobacterium.
Christian Milani,Gabriele Andrea Lugli,Sabrina Duranti,Francesca Turroni,Francesca Bottacini,Marta Mangifesta,Borja Sánchez,Alice Viappiani,Leonardo Mancabelli,Bernard Taminiau,Véronique Delcenserie,Rodolphe Barrangou,Abelardo Margolles,Douwe van Sinderen,Marco Ventura +14 more
TL;DR: In this paper, the genomes of 42 representative (sub)species across the Bifidobacterium genus were sequenced and used to explore the overall genetic picture of this bacterial group.
Journal ArticleDOI
The Spectrum of Achalasia: Lessons From Studies of Pathophysiology and High-Resolution Manometry
TL;DR: It has become apparent that the cardinal feature of achalasia, impaired lower esophageal sphincter relaxation, can occur in several disease phenotypes; however, without a disease-specific biomarker, no manometric pattern is absolutely specific.
Journal ArticleDOI
Toll-like receptor 4 is expressed on intestinal stem cells and regulates their proliferation and apoptosis via the p53 up-regulated modulator of apoptosis.
Matthew D. Neal,Chhinder P. Sodhi,Hongpeng Jia,Mitchell Dyer,Charlotte E. Egan,Ibrahim Yazji,Misty Good,Amin Afrazi,Ryan T. Marino,Dennis Slagle,Congrong Ma,Maria F. Branca,Thomas Prindle,Zachary Grant,John A. Ozolek,David J. Hackam +15 more
TL;DR: These findings illustrate that TLR4 is expressed on ISCs where it regulates their proliferation and apoptosis through activation of PUMA and thatTLR4 regulation of ISCs contributes to the pathogenesis of necrotizing enterocolitis.
References
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Recognition of Commensal Microflora by Toll-Like Receptors Is Required for Intestinal Homeostasis
Seth Rakoff-Nahoum,Justin C. Paglino,Fatima Eslami-Varzaneh,Stephen C. Edberg,Ruslan Medzhitov +4 more
TL;DR: It is shown that commensal bacteria are recognized by TLRs under normal steady-state conditions, and this interaction plays a crucial role in the maintenance of intestinal epithelial homeostasis and protection from injury.
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Soluble proteins produced by probiotic bacteria regulate intestinal epithelial cell survival and growth.
Fang Yan,Hanwei Cao,Timothy L. Cover,Timothy L. Cover,Robert H. Whitehead,M. Kay Washington,D. Brent Polk +6 more
TL;DR: The probiotic bacterium Lactobacillus rhamnosus GG and factors recovered from LGG broth culture supernatant (LGG-s) prevent cytokine-induced apoptosis in human and mouse intestinal epithelial cells by regulating signaling pathways as mentioned in this paper.
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Intestinal microflora in early infancy: composition and development
TL;DR: Environmental factors are indeed extremely important for the intestinal colonization of infants born by caesarean section and hospitalization in neonatal intensive care units, characterized by prolonged antibiotic therapy, parenteral nutrition, delayed oral feedings and intubation seems to affect the composition of the intestinal microbiota.
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Toll-like receptor 2 controls mucosal inflammation by regulating epithelial barrier function.
TL;DR: Data from in vitro and ex vivo models of intestinal epithelial cells revealed that TLR2 stimulation effectively preserves TJ-associated barrier assembly against stress-induced damage through promotion of PI3K/Akt-mediated cell survival via MyD88.
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Probiotic Bacterium Prevents Cytokine-induced Apoptosis in Intestinal Epithelial Cells
Fang Yan,D. Brent Polk +1 more
TL;DR: Observations suggest a novel mechanism of communication between probiotic microorganisms and epithelia that increases survival of intestinal cells normally found in an environment of pro-apoptotic cytokines.