Journal ArticleDOI
Bio-active mixed ligand Cu(II) and Zn(II) complexes of pyrimidine derivative Schiff base: DFT calculation, antimicrobial, antioxidant, DNA binding, anticancer and molecular docking studies
Nagaraj Revathi,Murugesan Sankarganesh,Jeyaraj Dhaveethu Raja,Gujuluva Gangatharan Vinoth Kumar,A. Sakthivel,R. Rajasekaran +5 more
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TLDR
In vitro cytotoxicity of the Schiff base (HL) and complexes 1–4 shows that complex 1 shows better ability to inhibit the growth of cancer cells and may be an appreciated material in cancer chemotherapy mediators in imminent years.Abstract:
A new series of bio active Cu(II) and Zn(II) complexes [CuL(phen)](OOCCH3) (1), [ZnL(phen)](OOCCH3) (2), [CuL(bpy)](OOCCH3) (3), [ZnL(bpy)](OOCCH3) (4) have been synthesized using the pyrimidine de...read more
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Synthesis, characterization, powder X-ray diffraction analysis, thermal stability, antioxidant properties and enzyme inhibitions of M(II)-Schiff base ligand complexes.
Kenan Buldurun,Nevin Turan,Ercan Bursal,Abdülmelik Aras,Asim Mantarcı,Naki Çolak,Fikret Türkan,İlhami Gülçin +7 more
TL;DR: The Schiff base ligand ((E)-6-methyl-2-(2,3,4-trimethoxybenzylideneamino)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carbonitrile) and its cobalt(II] and palladium(II) complexes were successfully prepared and the structure was elucidated by various techniques.
Journal ArticleDOI
Synthesis, characterization and DNA interaction of a novel Pt(II) macroacyclic Schiff base complex containing the piperazine moiety and its cytotoxicity and molecular docking
TL;DR: In this paper, a new platinum Schiff base complex, [C17H28N4OPt]Cl2 (1) was prepared from the condensation of a polyamine containing piperazine moiety, (1,4-bis(3-aminopropyl)piperazine) and 2-hydroxy-benzaldehyde (H2L), in the presence of Pt2+ ion and examined by mass, FT-IR, elemental analysis 1H NMR and 13C NMR.
Journal ArticleDOI
Biologically relevant and energetically significant cooperative ternary (π–π)2/(π–π)1/(π–π)2 assemblies and fascinating discrete (H2O)21 clusters in isostructural 2,5-pyridine dicarboxylato Co(II) and Zn(II) phenanthroline compounds: antiproliferative evaluation and theoretical studies
Sanjib Chetry,Pranay Sharma,Antonio Frontera,Utpal Saha,Akalesh K. Verma,Bipul Sarma,Paran Jyoti Kalita,Manjit K. Bhattacharyya +7 more
TL;DR: In this article, two new isostructural coordination compounds of cobalt and zinc involving 1,10-phenanthroline and 2,5-pyridine dicarboxylate were synthesized and characterised using FT-IR, electronic spectroscopy, thermal analysis, elemental analysis and single crystal X-ray diffraction techniques.
Journal ArticleDOI
Synthesis and toxicity assessment of Fe3O4 NPs grafted by ∼ NH2-Schiff base as anticancer drug: modeling and proposed molecular mechanism through docking and molecular dynamic simulation.
TL;DR: It is found that the higher toxicity of Fe3O4@SiO2@APTS ∼ Schiff base-Cu(II) (IC50: 1000 μg/mL) is due to their stronger in situ degradation, with larger intracellular release of iron ions, as compared to surface passivated NPs.
Journal ArticleDOI
DNA/BSA binding affinity studies of new Pd(II) complex with S-S and N-N donor mixed ligands via experimental insight and molecular simulation: Preliminary antitumor activity, lipophilicity and DFT perspective
TL;DR: In this paper, a novel water-like palladium(II) complex, [Pd(phen)(proli-dtc)]NO3 (phen = 1,10-phenanthroline and proli -dtc = pyrrolinedithiocarbamate), has been prepared.
References
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Journal ArticleDOI
A simple pyrazine based ratiometric fluorescent sensor for Ni2+ ion detection
Mohanasundaram Dhanushkodi,Gujuluva Gangatharan Vinoth Kumar,Balakrishnan Kalaiarasan Balachandar,S. Sarveswari,Sivaraman Gandhi,Jegathalaprathaban Rajesh +5 more
TL;DR: In this article, the existing mercury sensor (R) could be applied for the detection of Ni2+ ion in both colorimetrically as well as fluorimetricically, and the results were theoretically supported using density functional theory (DFT).
Journal ArticleDOI
Cytotoxic malonate platinum(II) complexes with 1,2,4-triazolo[1,5-a]pyrimidine derivatives: structural characterization and mechanism of the suppression of tumor cell growth
TL;DR: The spectroscopic characterization unambiguously confirmed the square-planar geometry of Pt(II) with two monodentate N3-bonded 5,7-disubstituted-1,2,4-triazolo[1,5-a]pyrimidines and one O-chelating malonate.
Journal ArticleDOI
Synthesis, spectral characterization, electrochemical, anti-microbial, DNA binding and cleavage studies of new binuclear Schiff base metal(II) complexes derived from o-hydroxyacetophenone
TL;DR: A tetradentate binucleating ligand was synthesized by condensation between 3, 3′-diaminobenzidine and o-hydroxyacetophenone in the molar ratio 1:4 as mentioned in this paper.
Journal ArticleDOI
Synthesis, characterization, and biological properties of Ni(II), Co(II), and Cu(II) complexes of Schiff bases derived from 4-aminobenzylamine
TL;DR: In this paper, N,N′-bis(salicylidene)-4-aminobenzylamine (H2L1), H2L2, H 2L3, and H3L4 have been synthesized and characterized by elemental analyses, electronic absorption, FT-IR, magnetic susceptibility, and conductance measurements.
Journal ArticleDOI
Platinum complex with pyrimidine- and morpholine-based ligand: synthesis, spectroscopic, DFT, TDDFT, catalytic reduction, in vitro anticancer, antioxidant, antimicrobial, DNA binding and molecular modeling studies.
TL;DR: Results proved that ligand and platinum bind to CT-DNA by intercalative binding mode by probing their ability to bind to calf thymus DNA with UV-Visible, fluorescence, viscometric measurements and cyclic voltammetric techniques.