Journal ArticleDOI
Bio-active mixed ligand Cu(II) and Zn(II) complexes of pyrimidine derivative Schiff base: DFT calculation, antimicrobial, antioxidant, DNA binding, anticancer and molecular docking studies
Nagaraj Revathi,Murugesan Sankarganesh,Jeyaraj Dhaveethu Raja,Gujuluva Gangatharan Vinoth Kumar,A. Sakthivel,R. Rajasekaran +5 more
Reads0
Chats0
TLDR
In vitro cytotoxicity of the Schiff base (HL) and complexes 1–4 shows that complex 1 shows better ability to inhibit the growth of cancer cells and may be an appreciated material in cancer chemotherapy mediators in imminent years.Abstract:
A new series of bio active Cu(II) and Zn(II) complexes [CuL(phen)](OOCCH3) (1), [ZnL(phen)](OOCCH3) (2), [CuL(bpy)](OOCCH3) (3), [ZnL(bpy)](OOCCH3) (4) have been synthesized using the pyrimidine de...read more
Citations
More filters
Journal ArticleDOI
Synthesis, structural analysis, in vitro antioxidant, antimicrobial activity and molecular docking studies of transition metal complexes derived from Schiff base ligands of 4-(benzyloxy)-2-hydroxybenzaldehyde
Journal ArticleDOI
Novel organoselenium-based N-mealanilic acid and its zinc (II) chelate: Catalytic, anticancer, antimicrobial, antioxidant, and computational assessments
TL;DR: In this article , the synthesis of two novel Zn(II)-complexes (Zn(LgSe)2 and Zn (Lg)2) starting from 4-((4-(methylselanyl)phenyl)amino)-4-oxobut-2-enoic acid (HLgSe), and 4-oxo-4-(p-tolylamino)but-2-, HLg) ligands, respectively, was reported.
Journal ArticleDOI
Novel metal(II) complexes with pyrimidine derivative ligand: synthesis, multi-spectroscopic, DNA binding/cleavage, molecular docking with DNA/BSA, and antimicrobial studies
Gurusamy Sankararaj Senthilkumar,Murugesan Sankarganesh,Murugesan Sankarganesh,Jeyraj Dhaveethu Raja,A. Sakthivel,Rajadurai Vijay Solomon,Liviu Mitu +6 more
TL;DR: In this paper, a series of metal(II) complexes of [Mn(L)(OAc)], [Co(L), [Ni(L)), [Cu(L, OAc), and [Zn[L], where HL is Schiff base ligand as 2-[(4,6-dimethylpyrimidin-2-ylimino)methyl]-6-methoxyphenol and -OAc is acetate have been synthesized and characterized by physico-chemical and different spectral techniques.
Journal ArticleDOI
Synthesis, characterization, DFT calculation, biological and molecular docking of Cu(II) complex of pyrimidine derived Schiff base ligand
Sahul Hameed Sukkur Saleem,Sahul Hameed Sukkur Saleem,Murugesan Sankarganesh,Murugesan Sankarganesh,Jeyaraj Dhaveethu Raja,Paul Raj Adwin Jose,A. Sakthivel,Thayalaraj Christopher Jeyakumar,Radhakrishnan Nandini Asha +8 more
TL;DR: In this paper, a biologically active Cu(II) complex was synthesized from pyrimidine based Schiff base ligand 4-choloro-2-(((4,6-dimethoxypyrimidin-2yl)imino)methyl)phenol.
Journal ArticleDOI
Spectroscopic, SOD, anticancer, antimicrobial, molecular docking and DNA binding properties of bioactive VO(IV), Cu(II), Zn(II), Co(II), Mn(II) and Ni(II) complexes obtained from 3-(2-hydroxy-3-methoxybenzylidene)pentane-2,4-dione.
TL;DR: The results demonstrate that most of the complexes have promising superoxide dismutase (SOD)-mimetic activity and the ligand is strong inhibitor for EGFR and HER2 while [VOL]SO4 is good inhibitor forEGFR and [ZnL]Cl2 is moderate inhibitor for HER2.
References
More filters
Journal ArticleDOI
Antioxidant Determinations by the Use of a Stable Free Radical
TL;DR: In this paper, the chemical nature of the antioxidant is known and a test specific for the compound or group of interest; for example, the nitroprusside test for sulphydryl groups.
Journal Article
The use of the stable free radical diphenylpicrylhydrazyl (dpph) for estimating antioxidant activity
TL;DR: The use of the stable free radical diphenylpicrylhydrazyl (DPPH) for estimating antioxidant activity and its application in antioxidant research is described.
Journal ArticleDOI
The electronic properties and stereochemistry of mono-nuclear complexes of the copper(II) ion
B.J. Hathaway,D.E. Billing +1 more