Journal ArticleDOI
Bioadhesive Tablets Influence of the Testing Medium Composition on Bioadhesion
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In this paper, a bioadhesive tablet of metronidazole has been developed for oral or vaginal administration, and the influence of the test medium was investigated in order to determine the adhesion of the tablet during routine use by the various routes.Abstract:
A bioadhesive tablet of metronidazole has been developed for oral or vaginal administration. The bioadhesive component is poly(acrylic acid) (Carbopol 934), and the matrix component is hydroxypropyl methylcellulose (HPMC K4M). The influence of the test medium was investigated in order to determine the adhesion of the tablet during routine use by the various routes. The parameter retained to evaluate adhesion was the adhesion work on a biological tissue. The factors whose influence was investigated were pH, ionic force and nature of cations, and type of biological substrateread more
Citations
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Journal ArticleDOI
Hydrogels as mucoadhesive and bioadhesive materials: a review
TL;DR: This review addresses several issues which clarify the central goals of bioadhesive drug delivery research and presents an overview of several proposed mechanisms of adhesion.
Journal ArticleDOI
Mucoadhesive Drug Delivery Systems
TL;DR: Some aspects of bioadhesion such as mucus layer, mucoadhesion, and theories ofBioadhesion to explain the adhesion mechanism are described.
Journal ArticleDOI
The use of mucoadhesive polymers in vaginal delivery
TL;DR: This review highlights the most important studies based on mucoadhesive polymer-systems like poly(acrylates), chitosan, cellulose derivatives, hyaluronic acid derivatives, pectin and traganth, starch, poly(ethylene glycol), sulfated polysaccharides, carrageenan, Na-alginate and gelatine.
Journal ArticleDOI
Drug transfer through mucus.
TL;DR: The study of the permeability of native or purified mucous gels is also important to understanding how it may alter the action or absorption of drugs that come in contact with epithelial surfaces.
Journal ArticleDOI
Design and testing in vitro of a bioadhesive and floating drug delivery system for oral application
TL;DR: The new oral controlled-release system shows, at least in vitro, good characetristics in relation to three parameters: controlled release of the drug, bioadhesiveness in the stomach and intestine of rabbits and buoyancy in an acid medium.
References
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Reference BookDOI
Polymer Interface and Adhesion
TL;DR: In this paper, the surface tension and surface tension of polymers were calculated from contact angles by the Harmonic-Mean and Geometric-means methods. But the results of the analysis of the contact angles were limited.
Journal ArticleDOI
Bioadhesive microspheres as a potential nasal drug delivery system
TL;DR: In vitro studies using model compounds showed high degrees of loading capacities for the various microspheres systems and it was possible to a certain degree to control the release of the compounds from the microsphere systems.
Journal ArticleDOI
Physico-chemical properties of water insoluble polymers important to mucin/epithelial adhesion☆
Haesun Park,Joseph R. Robinson +1 more
TL;DR: In this article, structural features of the adhesive polymer were explored using a copolymer of acrylic and methacrylic acid with variation in charge density and hydrophobicity of the molecules.
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Bioadhesive analysis of controlled-release systems. i. fracture and interpenetration analysis in poly(acrylic acid)-containing systems
TL;DR: In this article, a modified tensile tester in contact with bovine sublingual mucus, and the force-elongation behavior was measured up to the breakpoint was calculated and related to bioadhesive characteristics of the tablets.
Journal ArticleDOI
The contribution of anionic polymer structural features to mucoadhesion
TL;DR: In this article, a series of 0.2% cross-linked copolymers (acrylic acid-methyl methacrylate) were synthesized using free-radical polymerization.