Journal ArticleDOI
Biological applications of functionalized calixarenes
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TLDR
The ability of calixarene derivatives to form stable complexes with biomolecules allows them to be applied for the development of biosensors and in the field of biology, biotechnology, and drug discovery.Abstract:
The functionalized calixarene derivatives exhibit remarkable properties towards organic and bioorganic molecules. However, the ability of calixarene derivatives to form stable complexes with biomolecules allows them to be applied for the development of biosensors and in the field of biology, biotechnology, and drug discovery. The applications of the functionalized calixarenes are summarized in this review, and an outlook for the future developments is discussed. A brief survey (of the last 10 years) on their biological application in various fields is also considered (199 references).read more
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Biomedical Applications of Supramolecular Systems Based on Host-Guest Interactions.
Xing Ma,Yanli Zhao +1 more
TL;DR: Host−Guest Supramolecular Chemistry A 1.1.1: Aims to explore the role of “ghostly” particles in the determination of chiral stationary phases and their role in the “spatially modified” states.
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Cu-Catalyzed Click Reaction in Carbohydrate Chemistry
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Surveying macrocyclic chemistry: from flexible crown ethers to rigid cyclophanes
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Cyclodextrin-based host-guest supramolecular nanoparticles for delivery: from design to applications.
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References
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Polyvalent Interactions in Biological Systems: Implications for Design and Use of Multivalent Ligands and Inhibitors.
TL;DR: Polyvalent interactions can be collectively much stronger than corresponding monovalent interactions, and they can provide the basis for mechanisms of both agonizing and antagonizing biological interactions that are fundamentally different from those available inmonovalent systems.
Journal ArticleDOI
Fluorescent and colorimetric sensors for detection of lead, cadmium, and mercury ions
TL;DR: In this critical review, the fluorescent and colorimetric sensors are classified according to their receptors into several categories, including small molecule based sensors, calixarene based Chemosensors, BODIPY based chemosensor, polymer based chemOSensors), DNA functionalized sensing systems, protein based sensing systems and nanoparticle based sensing Systems.
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Discovery and Development of Folic-Acid-Based Receptor Targeting for Imaging and Therapy of Cancer and Inflammatory Diseases
TL;DR: The quest for the ideal targeted therapeutic agent was described, which began with a search for ligands that would bind selectively to pathologic cells, displaying no affinity for healthy cells, and held great promise for increasing the potency while reducing toxicity of many cancer therapies.
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Protein chip technology
Heng Zhu,Michael Snyder +1 more
TL;DR: Recent progress in the field of protein chips includes surface chemistry, capture molecule attachment, protein labeling and detection methods, high-throughput protein/antibody production, and applications to analyse entire proteomes.
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The role of dioleoyl phosphatidylethanolamine in cationic liposome mediated gene transfer
TL;DR: An endocytosis model of DNA delivery by cationic liposomes is proposed in which the principal function of the chase liposome is to destabilize the endosome membrane and allow the release of DNA into the cytosol.