Journal ArticleDOI
Biologically Active Pyraaoles
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This article is published in Journal of Pharmaceutical Sciences.The article was published on 1968-04-01. It has received 66 citations till now.read more
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Pyrazole scaffold: a remarkable tool in the development of anticancer agents.
TL;DR: The use of molecular modeling is reviewed in the designing of novel pyrazole analogs that may target various receptors such as protein kinase inhibitor, tyrosine kinases, Aurora-A kinase, tumor growth factor, cyclin dependent kinase (CDK) and fibroblast growth factor (FGF), which are significant for the management of cancer.
Journal ArticleDOI
Translating High-Temperature Microwave Chemistry to Scalable Continuous Flow Processes
TL;DR: In this paper, a comparison between batch microwave and conventionally heated continuous flow scale-up protocols for three selected model reactions is presented using high-temperature/high-pressure conditions as process intensification principles.
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Synthesis, antitubercular and antimicrobial evaluation of 3-(4-chlorophenyl)-4-substituted pyrazole derivatives
TL;DR: The results suggest that hydrazones, 2-azetidinones and 4-thiazolidinones bearing a core pyrazole scaffold would be potent antimicrobial and antitubercular agents.
Journal ArticleDOI
Phosphonylpyrazoles from Bestmann-Ohira reagent and nitroalkenes: synthesis and dynamic NMR studies.
TL;DR: Detailed dynamic NMR studies were performed on the prototropic tautomerism exhibited by the phosphonylpyrazoles and unraveled the existence of two tautomers in solution with a small energy difference but considerable barrier to interconversion.
Journal ArticleDOI
Efficient One-Pot Three-Component Synthesis of Fused Pyridine Derivatives in Ionic Liquid
TL;DR: An efficient one-pot synthesis of fused pyridine derivatives by three-component reaction of aldehyde, acyl acetonitrile, and electron-rich amino heterocycles (including aminopyrazole and aminouracils) in ionic liquid is reported.
References
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The chemistry of heterocyclic compounds
TL;DR: In this article, it was shown that one of the most common types of known quantities of phenyl phenyl is phenyl oxide (POP) oxide, which is a phenyl-oxyoxy phenyl (PE)-oxyoxyphenyl) that can be obtained from phenyl compounds.
Journal ArticleDOI
Acute toxicity of pesticides.
TL;DR: LD50 values for rats treated by the dermal route with parathion or dichlorvos and restrained so as to prevent the possibility of oral or respiratory exposure were not significantly different from those values in rats treated according to the procedure used routinely in this laboratory.
Journal ArticleDOI
Potentiation by inhibition of drug degradation : 6-substituted purines and xanthine oxidase
Gertrude B. Elion,Sandra Callahan,Henry Nathan,Samuel Bieber,R. Wayne Rundles,George H. Hitchings +5 more
TL;DR: The inhibition of metabolic degradation by the xanthine oxidase inhibitor results in several-fold potentiations of 6-mercaptopurine, 6-methylthiopurine), 6-propylthiopoline, and 6-chloropurines in trials against adenocarcinoma 755 and of 4-hydroxypyrazolo (3, 4-d)pyrimidine as inhibitors of the immune response of mice to sheep erythrocytes
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The acute toxicity of pesticides to rats
TL;DR: A comparison of laboratory results and use experience indicates that there is a much closer relationship between dermal LD 50 values and the occurrence of occupational poisoning than between oral LD50 values and occupational poisoning.