Journal ArticleDOI
Indoles - A promising scaffold for drug development.
T.V. Sravanthi,S. L. Manju +1 more
TLDR
A clear knowledge is provided on the wide-ranging biological activities of 2-arylindoles over the past two decades, which would be beneficial for the designing of more potent drug targets in order to compete with the existing drugs.About:
This article is published in European Journal of Pharmaceutical Sciences.The article was published on 2016-08-25. It has received 354 citations till now. The article focuses on the topics: Drug development.read more
Citations
More filters
Journal ArticleDOI
Medicinal chemistry of indole derivatives: Current to future therapeutic prospectives.
Archana Kumari,Rajesh K. Singh +1 more
TL;DR: This review summarizes some of the recent effective chemical synthesis (2014-2018) for indole ring and emphasized on the structure-activity relationship (SAR) to reveal the active pharmacophores of various indole analogues accountable for anticancer, anticonvulsant, antimicrobial, antitubercular, antimalarial, antiviral, antidiabetic and other miscellaneous activities which have been investigated in the last five years.
Journal ArticleDOI
Indole: A privileged scaffold for the design of anti-cancer agents.
TL;DR: This review aimed to provide a clear knowledge on the recent development of indoles as anti-cancer agents, such as myeloid cell leukemia-1 (Mcl-1) inhibitors, proviral insertion site in moloney murine leukemia virus (Pim), and made an insight into the corresponding structure-activity relationships (SARs).
Journal ArticleDOI
Indole in the target-based design of anticancer agents: A versatile scaffold with diverse mechanisms.
Sakineh Dadashpour,Saeed Emami +1 more
TL;DR: The present article aims to review the current application of indole core in the design of new anticancer agents that may act via various targets such as histone deacetylases, sirtuins, PIM kinases, DNA topoisomerases and σ receptors.
Journal ArticleDOI
Predictive Model for Site-Selective Aryl and Heteroaryl C-H Functionalization via Organic Photoredox Catalysis.
TL;DR: Using electron density calculations, this work was able to predict the site selectivity of direct C-H functionalization in a number of heterocycles and identify general trends observed across heterocycle classes.
Journal ArticleDOI
Highly Robust but Surface‐Active: An N‐Heterocyclic Carbene‐Stabilized Au25 Nanocluster
Hui Shen,Guocheng Deng,Sami Kaappa,Tong-De Tan,Ying-Zi Han,Sami Malola,Shui-Chao Lin,Boon K. Teo,Hannu Häkkinen,Nanfeng Zheng +9 more
TL;DR: A novel N-heterocyclic carbene-stabilized Au25 nanocluster with high thermal and air stabilities as a homogenous catalyst for cycloisomerization of alkynyl amines to indoles for liquid-phase catalysis is reported.
References
More filters
Journal ArticleDOI
Guidelines for the use of antiretroviral agents in HIV-infected adults and adolescents
Anthony S. Fauci,John G. Bartlett,Eric P. Goosby,M. D. Smith,H. J. Kaiser,S. W. Chang,James M. Anderson,R. Armstead,A. C. Baker,David A Barr,Samuel A. Bozzette,S. Cox,M. Delaney,Fred M. Gordin,W. Greaves,M. Harrington,J. J. Henning,Martin S. Hirsch,J. Jacobs,Richard Marlink,C. Maxwell,J. W. Mellors,D. B. Nash,S. Perryman,Robert T. Schooley,R. Sherer,Stephen A. Spector,G. Torres,Paul A. Volberding,B. A. Brady,E. M. Daniels,D. Feigal,Mark B. Feinberg,H. D. Gayle,T. R. Graydon,Jonathan E. Kaplan,Abe M. Macher,R. F. Martin,Henry Masur,Lynne M. Mofenson,J. Murray,J. O'Neill,L. C. Perez,R. Riseberg,S. Shekar,Sharilyn K. Stanley,J. Whitescarver +46 more
TL;DR: These Guidelines were developed by the Panel* on Clinical Practices for Treatment of HIV Infection convened by the Department of Health and Human Services and the Henry J. Kaiser Family Foundation.
Journal ArticleDOI
The Expanded Biology of Serotonin
TL;DR: New work suggests that serotonin may regulate some processes, including platelet aggregation, by receptor-independent, transglutaminase-dependent covalent linkage to cellular proteins.
Journal ArticleDOI
Marine indole alkaloids: potential new drug leads for the control of depression and anxiety
TL;DR: Information is provided on current and potential pharmaceuticals including small molecule natural indole alkaloids to their biological properties, structure-activity relationship studies, and especially their potential for the treatment of neurological disorders, including depression.
Journal ArticleDOI
Biomedical Importance of Indoles
Nagendra Kumar Kaushik,Neha Kaushik,Pankaj Attri,Naresh Kumar,Chung Hyeok Kim,Akhilesh K. Verma,Eun Ha Choi +6 more
TL;DR: Some of the relevant and recent achievements in the biological, chemical and pharmacological activity of important indole derivatives in the areas of drug discovery and analysis are covered.
Journal Article
Pharmacology of Penile Erection
TL;DR: Dopamine receptors in central nervous centers participating in the initiation of erection have been targeted for the treatment of ED, and Apomorphine, administered sublingually, is the first of such drugs.