Journal ArticleDOI
Bisphosphonates in the adjuvant treatment of breast cancer.
TLDR
There have been mixed results from large adjuvant metastasis-prevention studies of bisphosphonates, but there are strong signals from large subgroups analyses of randomised phase III trials suggesting significant anti-tumour beneficial effects in specific patient populations.About:
This article is published in Clinical Oncology.The article was published on 2013-02-01. It has received 25 citations till now. The article focuses on the topics: Zoledronic acid & Breast cancer.read more
Citations
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Journal ArticleDOI
Crosstalk between bone niche and immune system: Osteoimmunology signaling as a potential target for cancer treatment
Carmen Criscitiello,Giulia Viale,Lucia Gelao,Angela Esposito,Michele De Laurentiis,Sabino De Placido,Michele Santangelo,Aron Goldhirsch,Giuseppe Curigliano +8 more
TL;DR: The co-regulation of the skeletal and immune systems strikingly exemplifies the extreme complexity of such an interaction and their interdependency must be considered in designing therapeutic approaches for either of the two systems.
Journal ArticleDOI
Incidence, risk factors and prognostic characteristics of bone metastases and skeletal-related events (SREs) in breast cancer patients: A systematic review of the real world data.
Hongwei Zhang,Wei Zhu,Ewelina Biskup,Ewelina Biskup,Weige Yang,Ziang Yang,Hong Wang,Xiaochun Qiu,Chengjiao Zhang,Guangxia Hu,Guangfu Hu +10 more
TL;DR: The unique characteristics of BM and SREs in breast cancer patients should be taken into account in future randomized controlled trials, as to optimize individual treatment options and assure a maximally long good quality of life.
Journal ArticleDOI
Differences of osteoblastic bone metastases and osteolytic bone metastases in clinical features and molecular characteristics.
TL;DR: Understanding the differences of bone metastases between two phenotypes is important to help clinicians to understand the underlying mechanisms, behaviors and therapies in development and currently available forBone metastases.
Journal ArticleDOI
Clodronate inhibits tumor angiogenesis in mouse models of ovarian cancer
Nicole M Reusser,Heather J. Dalton,Sunila Pradeep,Vianey Gonzalez-Villasana,Nicholas B. Jennings,Hernan G. Vasquez,Yunfei Wen,Rajesha Rupaimoole,Archana S. Nagaraja,Kshipra M. Gharpure,Takahito Miyake,Jie Huang,Wei Hu,Gabriel Lopez-Berestein,Anil K. Sood +14 more
TL;DR: Clodronate is a potent inhibitor of tumor angiogenesis and macrophage density and is highlighted as a potential therapeutic for cancer by in vitro and in vivo models.
Journal ArticleDOI
Update on breast cancer risk prediction and prevention.
Ivana Sestak,Jack Cuzick +1 more
TL;DR: It still remains unclear how to prevent oestrogen-negative breast cancer, which occurs more often in premenopausal women, and the inclusion of breast density and a panel of genetic polymorphisms, which individually have low penetrance, can improve risk assessment.
References
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Journal ArticleDOI
Metastasis to bone: causes, consequences and therapeutic opportunities
TL;DR: The most common human cancers — lung, breast and prostate — have a great avidity for bone, leading to painful and untreatable consequences.
Journal ArticleDOI
Bisphosphonate-associated osteonecrosis of the jaw: Report of a Task Force of the American Society for Bone and Mineral Research
Sundeep Khosla,David B. Burr,Jane A. Cauley,David W. Dempster,Peter R. Ebeling,Dieter Felsenberg,Robert F. Gagel,Vincente Gilsanz,Theresa A. Guise,Sreenivas Koka,Laurie K. McCauley,Joan McGowan,Marc D. McKee,Suresh Mohla,David G. Pendrys,Lawrence G. Raisz,Salvatore L. Ruggiero,David Shafer,Lillian Shum,Stuart L. Silverman,Catherine Van Poznak,Nelson B. Watts,Sook-Bin Woo,Elizabeth Shane +23 more
TL;DR: This report summarizes the findings and recommendations of the task force to address key questions related to case definition, epidemiology, risk factors, diagnostic imaging, clinical management, and future areas for research related to the disorder.
Journal ArticleDOI
Nitrogen-Containing Bisphosphonates Inhibit the Mevalonate Pathway and Prevent Post-Translational Prenylation of GTP-Binding Proteins, Including Ras
Steven P. Luckman,Steven P. Luckman,D. E. Hughes,F P Coxon,F P Coxon,R. Graham G. Russell,Michael J. Rogers +6 more
TL;DR: Nitrogen‐containing bisphosphonate drugs cause apoptosis following inhibition of post‐translational prenylation of proteins such as Ras, and the data support the view that clodronate acts by a different mechanism.
Journal ArticleDOI
Endocrine Therapy plus Zoledronic Acid in Premenopausal Breast Cancer
Michael Gnant,Brigitte Mlineritsch,Walter Schippinger,G. Luschin-Ebengreuth,Sabine Pöstlberger,Christian Menzel,Raimund Jakesz,Michael Seifert,Michael Hubalek,Vesna Bjelic-Radisic,Hellmut Samonigg,C. Tausch,Holger Eidtmann,Guenther G. Steger,Werner Kwasny,Peter Dubsky,M. Fridrik,Florian Fitzal,Michael Stierer,Ernst Rücklinger,Richard Greil +20 more
TL;DR: The addition of zoledronic acid to adjuvant endocrine therapy improves disease-free survival in premenopausal patients with estrogen-responsive early breast cancer.
Journal ArticleDOI
Cellular and molecular mechanisms of action of bisphosphonates
Michael J. Rogers,Sharon Gordon,H L Benford,Fraser P. Coxon,S. P. Luckman,Jukka Mönkkönen,Julie C. Frith +6 more
TL;DR: Bisphosphonates currently are the most important class of antiresorptive agents used in the treatment of metabolic bone diseases, including tumor‐associated osteolysis and hypercalcemia, Paget's disease, and osteoporosis.
Related Papers (5)
Oral clodronate for adjuvant treatment of operable breast cancer (National Surgical Adjuvant Breast and Bowel Project protocol B-34): a multicentre, placebo-controlled, randomised trial
Alexander H.G. Paterson,Stewart J. Anderson,Barry C. Lembersky,Louis Fehrenbacher,Carla I. Falkson,Carla I. Falkson,Karen M. King,Lorna Weir,Adam Brufsky,Shaker R. Dakhil,Thomas Lad,Luis Baez-Diaz,Julie R. Gralow,André Robidoux,Edith A. Perez,Edith A. Perez,Ping Zheng,Charles E. Geyer,Sandra M. Swain,Joseph P. Costantino,Eleftherios P. Mamounas,Norman Wolmark +21 more