Breast cancer treatment: A phased approach to implementation.
Miriam Mutebi,Benjamin O. Anderson,Benjamin O. Anderson,Catherine Duggan,Clement Adebamowo,Gaurav Agarwal,Zipporah Ali,Peter Bird,Jean Marc Bourque,Jean Marc Bourque,Rebecca DeBoer,Luiz Henrique Gebrim,Riccardo Masetti,Shahla Masood,Manoj Menon,Gertrude Nakigudde,Anne Ng’ang’a,Nixon Niyonzima,Anne F. Rositch,Karla Unger-Saldaña,Cynthia Villarreal-Garza,Allison Dvaladze,Nagi S. El Saghir,Julie R. Gralow,Alexandru Eniu +24 more
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TLDR
This strategy proposes that, after a situational analysis, implementation phases begin with bolstering palliative care capacity, especially in settings where a late‐stage diagnosis is common, followed by strengthening the patient pathway.Abstract:
Optimal treatment outcomes for breast cancer are dependent on a timely diagnosis followed by an organized, multidisciplinary approach to care. However, in many low- and middle-income countries, effective care management pathways can be difficult to follow because of financial constraints, a lack of resources, an insufficiently trained workforce, and/or poor infrastructure. On the basis of prior work by the Breast Health Global Initiative, this article proposes a phased implementation strategy for developing sustainable approaches to enhancing patient care in limited-resource settings by creating roadmaps that are individualized and adapted to the baseline environment. This strategy proposes that, after a situational analysis, implementation phases begin with bolstering palliative care capacity, especially in settings where a late-stage diagnosis is common. This is followed by strengthening the patient pathway, with consideration given to a dynamic balance between centralization of services into centers of excellence to achieve better quality and decentralization of services to increase patient access. The use of resource checklists ensures that comprehensive therapy or palliative care can be delivered safely and effectively. Episodic or continuous monitoring with established process and quality metrics facilitates ongoing assessment, which should drive continual process improvements. A series of case studies provides a snapshot of country experiences with enhancing patient care, including the implementation of national cancer control plans in Kenya, palliative care in Romania, the introduction of a 1-stop clinic for diagnosis in Brazil, the surgical management of breast cancer in India, and the establishment of a women's cancer center in Ghana.read more
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The Breast Health Global Initiative 2018 Global Summit on Improving Breast Healthcare Through Resource-Stratified Phased Implementation: Methods and overview
Catherine Duggan,Allison Dvaladze,Anne F. Rositch,Ophira Ginsburg,Cheng Har Yip,Susan Horton,Rolando Camacho Rodriguez,Alexandru Eniu,Miriam Mutebi,Jean Marc Bourque,Jean Marc Bourque,Shahla Masood,Karla Unger-Saldaña,Anna Cabanes,Robert W. Carlson,Julie R. Gralow,Benjamin O. Anderson,Benjamin O. Anderson +17 more
TL;DR: The 6th Global Summit on Improving Breast Healthcare Through Resource-Stratified Phased Implementation (GSIP) as discussed by the authors focused on three specific aspects of breast cancer care: early detection, treatment and health system strengthening.
Journal ArticleDOI
Aptamer grafted nanoparticle as targeted therapeutic tool for the treatment of breast cancer
TL;DR: In this article , a review of aptamer-based biosensor in breast cancer diagnosis has been presented, and the appropriate usage of the aptamer based biosensor has also been discussed, where the authors showcase the method and modified method of selection of aptamers, aptamer that were able to make its way towards clinical trial and their targetability and selectivity towards breast cancers.
Journal ArticleDOI
Nanoparticles Targeting Receptors on Breast Cancer for Efficient Delivery of Chemotherapeutics.
TL;DR: The authors in this paper presented an overview of the principle of targeted delivery approaches, exploiting drug-nanoparticle conjugates with multiple targeting moieties to target specific receptors of breast cancer cells and highlighting therapeutic evaluation in preclinical studies.
Journal ArticleDOI
NCCN resource-stratified and harmonized guidelines: A paradigm for optimizing global cancer care
TL;DR: The critical need for local expertise and involvement in successful development and uptake is emphasized, and the promise of this collaboration for advancement in oncology programs is illustrated.
Journal ArticleDOI
Enhanced Cytotoxic Activity of Docetaxel-Loaded Silk Fibroin Nanoparticles against Breast Cancer Cells.
Ahmed Al Saqr,Shahid Ud Din Wani,H.V. Gangadharappa,Mohammed F. Aldawsari,El-Sayed Khafagy,El-Sayed Khafagy,Amr S. Abu Lila +6 more
TL;DR: In this article, the authors presented the feasibility of using silk fibroin nanoparticles (SF-NPs) as a nontoxic biocompatible delivery vehicle for enhanced therapeutic outcomes in breast cancer.
References
More filters
Journal ArticleDOI
Twenty-year follow-up of a randomized trial comparing total mastectomy, lumpectomy, and lumpectomy plus irradiation for the treatment of invasive breast cancer.
Bernard Fisher,Stewart J. Anderson,John Bryant,Richard G. Margolese,Melvin Deutsch,Edwin R. Fisher,Jong-Hyeon Jeong,Norman Wolmark +7 more
TL;DR: Lumpectomy followed by breast irradiation continues to be appropriate therapy for women with breast cancer, provided that the margins of resected specimens are free of tumor and an acceptable cosmetic result can be obtained.
Journal ArticleDOI
Twenty-Year Follow-up of a Randomized Study Comparing Breast-Conserving Surgery with Radical Mastectomy for Early Breast Cancer
Umberto Veronesi,Natale Cascinelli,Luigi Mariani,Marco Greco,R. Saccozzi,Alberto Luini,Marisel Aguilar,Ettore Marubini +7 more
TL;DR: The long-term survival rate among women who undergo breast-conserving surgery is the same as that among women Who undergo radical mastectomy, and Breast-conserve surgery is therefore the treatment of choice for women with relatively small breast cancers.
OtherDOI
The International Bank for Reconstruction and Development: The World Bank
Peter Coffey,Robert J. Riley +1 more
Journal ArticleDOI
Prevalence of pain in patients with cancer: a systematic review of the past 40 years
M.H.J. van den Beuken-van Everdingen,J.M. de Rijke,Alphons G.H. Kessels,Harry C. Schouten,M. van Kleef,Jacob Patijn +5 more
TL;DR: Pooled prevalence of pain was >50% in all cancer types with the highest prevalence in head/neck cancer patients (70%; 95% CI 51% to 88%).
Journal ArticleDOI
Effect of radiotherapy after mastectomy and axillary surgery on 10-year recurrence and 20-year breast cancer mortality: meta-analysis of individual patient data for 8135 women in 22 randomised trials
Paul McGale,Carolyn W. Taylor,C Correa,D Cutter,F Duane,Marianne Ewertz,Richard Gray,Gurdeep S. Mannu,Richard Peto,Timothy J. Whelan,Yixin Wang,Zhe Wang,Sarah C. Darby +12 more
TL;DR: After mastectomy and axillary dissection, radiotherapy reduced both recurrence and breast cancer mortality in the women with one to three positive lymph nodes in these trials even when systemic therapy was given.
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