Journal ArticleDOI
Bromocriptine in the prevention of alcohol abuse
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TLDR
Global evaluation of bromocriptine treatment was beneficial in most patients, with a substantial reduction in the number of patients abusing alcohol, indicating that bromOCriptine may affect the craving.Abstract:
– – In a double-blind trial comprising 50 chronic alcoholics, randomized in two parallel groups, bromocriptine was compared with placebo on psycho-social variables in the prevention of alcohol abuse for 6 months. The overall effects on the abuse situation, social functioning, social belonging and psychic status were significantly bettered by bromocriptine. Craving was reduced from strong to very mild, indicating a distancing effect of bromocriptine on dependency. Neurotic states and depressive reactions were significantly improved by bromocriptine, as were social situation, motivation and personal insight. Global evaluation of bromocriptine treatment was beneficial in most patients, with a substantial reduction in the number of patients abusing alcohol. Our results indicate that bromocriptine may affect the craving.read more
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Methamphetamine-related psychiatric symptoms and reduced brain dopamine transporters studied with PET.
Yoshimoto Sekine,Masaomi Iyo,Yasuomi Ouchi,Tsutomu Matsunaga,Hideo Tsukada,Hiroyuki Okada,Etsuji Yoshikawa,Masami Futatsubashi,Nori Takei,Norio Mori +9 more
TL;DR: The findings suggest that longer use of methamphetamine may cause more severe psychiatric symptoms and greater reduction of dopamine transporter density in the brain, and show that the dopamine transporter reduction may be long-lasting, even if methamphetamine use ceases.
Journal ArticleDOI
Comparison of acamprosate and placebo in long-term treatment of alcohol dependence.
Alexandra B. Whitworth,H. Oberbauer,W. Wolfgang Fleischhacker,Otto M. Lesch,H Walter,A Nimmerrichter,T Platz,F Fischer,A Potgieter +8 more
TL;DR: Acamprosate is an effective and well-tolerated pharmacological adjunct to psychosocial and behavioural treatment programmes for treatment of alcohol-dependent patients and is well matched in terms of baseline demographic and alcohol-related variables.
Journal ArticleDOI
Neurotransmitter and neuromodulatory mechanisms involved in alcohol abuse and alcoholism.
I. Nevo,Michel Hamon +1 more
TL;DR: This review examines the studies which have attempted to elucidate the roles of these neurotransmitter systems in the mechanisms involved in the various aspects of alcohol abuse and alcoholism, with an emphasis on recent developments.
Journal ArticleDOI
Dopamine and alcoholism: neurobiological basis of ethanol abuse.
Erkki Tupala,Jari Tiihonen +1 more
TL;DR: The present animal and human data suggest several alterations in the DA system in the context of alcoholism, which could help to restore suboptimal levels of DAergic activity by reducing both the craving for alcohol in abstinence and the euphoria subsequent to alcohol's release of DA in the nucleus accumbens, thus providing negative reinforcement for relapse.
Journal ArticleDOI
Bromocriptine in the treatment of alcoholics with the D2 dopamine receptor A1 allele.
Bruce R. Lawford,Ross McD. Young,J. Rowell,Joan Qualichefski,Barbara H. Fletcher,Karl Syndulko,Terry Ritchie,Ernest P. Noble +7 more
TL;DR: In a double-blind study, bromocriptine, a DRD2 agonist, or placebo was administered to alcoholics with either the A1 or A2 genotypes or only the A2 (A2/A2 genotype) allele of theDRD2 gene, and the greatest improvement in craving and anxiety occurred in the bromOCriptine-treated A1 alcoholics.
References
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Journal ArticleDOI
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Journal ArticleDOI
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Journal ArticleDOI
Bromocriptine treatment of depressive disorders. Clinical and biochemical effects.
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