Campath‐1H Induction Plus Rapamycin Monotherapy for Renal Transplantation: Results of a Pilot Study
Stuart J. Knechtle,John D. Pirsch,John H. Fechner,Bryan N. Becker,Andreas Friedl,Robert B. Colvin,Lauralynn K. Lebeck,L. Thomas Chin,Yolanda T. Becker,Jon S. Odorico,Anthony M. D'Alessandro,Munci Kalayoglu,Majed M. Hamawy,Huaizhong Hu,Debra D. Bloom,Hans W. Sollinger +15 more
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TLDR
Insight is provided into the use of Campath‐1H induction in combination with rapamycin maintenance monotherapy in 29 primary human renal transplants and how the immunosuppressive regimen is modified in subsequent pilot studies.About:
This article is published in American Journal of Transplantation.The article was published on 2003-06-01 and is currently open access. It has received 371 citations till now. The article focuses on the topics: Transplantation & Chronic allograft nephropathy.read more
Citations
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Journal ArticleDOI
Immunosuppressive Drugs for Kidney Transplantation
TL;DR: This review considers the use of immunosuppressive drugs in organ transplantation, focusing on renal transplantation.
Journal ArticleDOI
Antibody-mediated organ-allograft rejection
Robert B. Colvin,R. Neal Smith +1 more
TL;DR: Antibody induces rejection acutely through the fixation of complement, resulting in tissue injury and coagulation, and complement activation recruits macrophages and neutrophils, causing additional endothelial injury.
Journal ArticleDOI
Immunocompetent T-cells with a memory-like phenotype are the dominant cell type following antibody-mediated T-cell depletion.
Jonathan P. Pearl,Jeremy Parris,Douglas A. Hale,Douglas A. Hale,Steven C. Hoffmann,Wendy B. Bernstein,Kelly L. McCoy,S. John Swanson,S. John Swanson,Roslyn B. Mannon,Mario Roederer,Allan D. Kirk,Allan D. Kirk +12 more
TL;DR: In this article, the authors evaluated the characteristics of post-depletional T cells with alemtuzumab or rabbit anti-thymocyte globulin following renal transplantation, evaluating the phenotype and functional characteristics of their residual cells.
Journal ArticleDOI
Homeostatic proliferation is a barrier to transplantation tolerance
Zihao Wu,Steven J. Bensinger,Jidong Zhang,C.W. Chen,Xueli Yuan,Xiaolun Huang,James F. Markmann,Alireza Kassaee,Bruce R. Rosengard,Wayne W. Hancock,Mohamed H. Sayegh,Laurence A. Turka +11 more
TL;DR: It is shown that residual nondepleted T cells undergo substantial homeostatic expansion in clinically relevant mouse models of peripheral T-cell depletion, demonstrating the barrier thatHomeostatic proliferation can present to the induction of transplantation tolerance, and have important implications for transplantation protocols that use partial or complete peripheral T -cell depletion.
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Transplantation 50 Years Later — Progress, Challenges, and Promises
TL;DR: A half-century has elapsed since the first transplantation, and this procedure is now accepted as the treatment of choice for end-stage organ failure, and several challenges remain if transplantation is to be widely available with minimal risks and optimal outcomes.
References
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Complement activation in acute humoral renal allograft rejection: diagnostic significance of C4d deposits in peritubular capillaries.
A. B. Collins,Eveline E. Schneeberger,Manuel Pascual,Susan L. Saidman,Winfred W. Williams,Nina Tolkoff-Rubin,Cosimi Ab,Robert B. Colvin +7 more
TL;DR: C4d in peritubular capillary walls distinguishes AHR from ACR, is more specific and sensitive than traditional criteria, and is a potentially valuable adjunct in the diagnosis of graft dysfunction.
Journal ArticleDOI
Acute Humoral Rejection in Kidney Transplantation: II. Morphology, Immunopathology, and Pathologic Classification
Shamila Mauiyyedi,Marta Crespo,A. Bernard Collins,Eveline E. Schneeberger,Manuel Pascual,Susan L. Saidman,Nina Tolkoff-Rubin,Winfred W. Williams,Francis L. Delmonico,A. Benedict Cosimi,Robert B. Colvin +10 more
TL;DR: The incidence of acute humoral rejection in renal allograft biopsies has been difficult to determine because widely accepted diagnostic criteria have not been established and non-HLA antibodies or subthreshold levels of DSA were detected in posttransplant recipient sera.
Journal ArticleDOI
Prope tolerance, perioperative campath 1H, and low-dose cyclosporin monotherapy in renal allograft recipients.
Roy Y. Calne,Peter J. Friend,S.D Moffatt,Andrew Bradley,Geoff Hale,John Firth,John Bradley,Ken R. Smith,Herman Waldmann +8 more
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Combined histocompatibility leukocyte antigen-matched donor bone marrow and renal transplantation for multiple myeloma with end stage renal disease: the induction of allograft tolerance through mixed lymphohematopoietic chimerism.
Thomas R. Spitzer,Francis L. Delmonico,Nina Tolkoff-Rubin,Steven L. McAfee,Robert Sackstein,Susan L. Saidman,Christine Colby,Megan Sykes,David H. Sachs,Cosimi Ab +9 more
TL;DR: This is the first report of the deliberate induction of mixed lymphohematopoietic chimerism after a nonmyeloablative preparative regimen to treat a hematological malignancy and to provide allotolerance for a solid organ transplant.
Journal ArticleDOI
Acute humoral rejection in renal allograft recipients: I. Incidence, serology and clinical characteristics.
Marta Crespo,Manuel Pascual,Nina Tolkoff-Rubin,Shamila Mauiyyedi,A. Bernard Collins,Donna M. Fitzpatrick,Mary Lin Farrell,Winfred W. Williams,Francis L. Delmonico,A. Benedict Cosimi,Robert B. Colvin,Susan L. Saidman +11 more
TL;DR: Most cases with DSA at the time of rejection had widespread C4d deposits in peritubular capillaries, suggesting a pathogenic role of the circulating alloantibody.